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• W2070230428 startingPage "2231" @default.
• W2070230428 abstract "In heterokaryons between senescent and young diploid fibroblast-like cells, dominance of the former with respect to nuclear DNA synthesis (incorporation of [(3)H]thymidine) was demonstrated. For identification of the respective partners, double-layer autoradiography was used after the old cells were labeled with [(3)H]methionine and the young cells were labeled with [(14)C]thymidine. Synchrony of nuclear labeling (i.e., all nuclei in a cell labeled with [(3)H]thymidine) was observed in the majority of di- and polykaryons during the second and third of three 24-hr periods of labeling with [(3)H]thymidine. The results are compatible with either terminal differentiation or error theories of clonal senescence." @default.
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• W2070230428 date "1974-06-01" @default.
• W2070230428 modified "2023-10-15" @default.
• W2070230428 title "Dominance of the Senescent Phenotype in Heterokaryons Between Replicative and Post-Replicative Human Fibroblast-Like Cells" @default.
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• W2070230428 doi "https://doi.org/10.1073/pnas.71.6.2231" @default.
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