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• W2070237364 abstract "The pathogenic mechanisms that lead to chronic kidney disease (CKD) converge on a common pathway that results in progressive interstitial fibrosis, peritubular capillary loss with hypoxia, and destruction of functioning nephrons because of tubular atrophy. Interstitial recruitment of inflammatory leukocytes and myofibroblasts occurs early in kidneys destined to develop fibrosis. Circulating monocytes are recruited by locally secreted chemoattractant molecules, facilitated by leukocyte adhesion molecules. Functionally heterogeneous macrophages secrete many fibrosis-promoting molecules, but under some circumstances they may also serve a protective scavenging role. Excessive extracellular matrix production occurs primarily within interstitial myofibroblasts, a population of cells that appears to have more than 1 origin, including the resident interstitial fibroblasts, trans-differentiated tubular epithelial cells, and bone marrow-derived cells. Impaired activity of the endogenous renal matrix-degrading proteases may enhance interstitial matrix accumulation, but the specific pathways that are involved remain unclear. Tubules, inflammatory cells, and myofibroblasts synthesize the molecules that activate the fibrogenic cascades, the most important of which is transforming growth factor beta (TGF-beta). TGF-beta may direct cells to assume a pro-fibrotic phenotype or it may do so indirectly after stimulating synthesis of other fibrogenic molecules such as connective tissue growth factor and plasminogen activator inhibitor-1. Reduced levels of antifibrotic factors that are normally produced in the kidney such as hepatocyte growth factor and bone morphogenic protein-7 may accelerate fibrosis and its destructive consequences. Development of new therapeutic agents for CKD looks promising, but several agents that target different components of the fibrogenic cascade will almost certainly be necessary." @default.
• W2070237364 created "2016-06-24" @default.
• W2070237364 creator A5001037908 @default.
• W2070237364 date "2005-10-01" @default.
• W2070237364 modified "2023-10-17" @default.
• W2070237364 title "Progression in Chronic Kidney Disease" @default.
• W2070237364 cites W1582409628 @default.
• W2070237364 cites W1973138150 @default.
• W2070237364 cites W1973782465 @default.
• W2070237364 cites W1977314871 @default.
• W2070237364 cites W1988193334 @default.
• W2070237364 cites W1993345123 @default.
• W2070237364 cites W1993756042 @default.
• W2070237364 cites W2004612291 @default.
• W2070237364 cites W2013483737 @default.
• W2070237364 cites W2016789558 @default.
• W2070237364 cites W2018036334 @default.
• W2070237364 cites W2023548286 @default.
• W2070237364 cites W2029581617 @default.
• W2070237364 cites W2035627251 @default.
• W2070237364 cites W2037268333 @default.
• W2070237364 cites W2040008785 @default.
• W2070237364 cites W2043703101 @default.
• W2070237364 cites W2050916570 @default.
• W2070237364 cites W2051042325 @default.
• W2070237364 cites W2055705210 @default.
• W2070237364 cites W2056194572 @default.
• W2070237364 cites W2058825719 @default.
• W2070237364 cites W2059346848 @default.
• W2070237364 cites W2065633653 @default.
• W2070237364 cites W2066297692 @default.
• W2070237364 cites W2068604817 @default.
• W2070237364 cites W2075528627 @default.
• W2070237364 cites W2077389455 @default.
• W2070237364 cites W2079131261 @default.
• W2070237364 cites W2079517510 @default.
• W2070237364 cites W2080627387 @default.
• W2070237364 cites W2082392205 @default.
• W2070237364 cites W2082776901 @default.
• W2070237364 cites W2082869755 @default.
• W2070237364 cites W2085943887 @default.
• W2070237364 cites W2088050057 @default.
• W2070237364 cites W2088668384 @default.
• W2070237364 cites W2090342049 @default.
• W2070237364 cites W2097160036 @default.
• W2070237364 cites W2097577343 @default.
• W2070237364 cites W2097975125 @default.
• W2070237364 cites W2100701085 @default.
• W2070237364 cites W2102141852 @default.
• W2070237364 cites W2110997620 @default.
• W2070237364 cites W2111235649 @default.
• W2070237364 cites W2113053279 @default.
• W2070237364 cites W2114245705 @default.
• W2070237364 cites W2115363040 @default.
• W2070237364 cites W2119682331 @default.
• W2070237364 cites W2127336805 @default.
• W2070237364 cites W2127801795 @default.
• W2070237364 cites W2129942918 @default.
• W2070237364 cites W2132526543 @default.
• W2070237364 cites W2132631212 @default.
• W2070237364 cites W2134785352 @default.
• W2070237364 cites W2135705997 @default.
• W2070237364 cites W2136291709 @default.
• W2070237364 cites W2140612433 @default.
• W2070237364 cites W2140759914 @default.
• W2070237364 cites W2140979322 @default.
• W2070237364 cites W2141374940 @default.
• W2070237364 cites W2142278869 @default.
• W2070237364 cites W2146232095 @default.
• W2070237364 cites W2146713188 @default.
• W2070237364 cites W2147100699 @default.
• W2070237364 cites W2147161251 @default.
• W2070237364 cites W2148184356 @default.
• W2070237364 cites W2150198473 @default.
• W2070237364 cites W2152689651 @default.
• W2070237364 cites W2165325650 @default.
• W2070237364 cites W2166607277 @default.
• W2070237364 cites W2167794093 @default.
• W2070237364 cites W2321064823 @default.
• W2070237364 cites W4238327329 @default.
• W2070237364 cites W4238849664 @default.
• W2070237364 cites W4240813384 @default.
• W2070237364 cites W4244029562 @default.
• W2070237364 cites W4244774747 @default.
• W2070237364 cites W4246557706 @default.
• W2070237364 cites W4250007760 @default.
• W2070237364 cites W4250450758 @default.
• W2070237364 cites W4250731522 @default.
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• W2070237364 doi "https://doi.org/10.1053/j.ackd.2005.07.011" @default.
• W2070237364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16198274" @default.
• W2070237364 hasPublicationYear "2005" @default.
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