Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070244414> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2070244414 endingPage "448" @default.
- W2070244414 startingPage "443" @default.
- W2070244414 abstract "Vascular endothelial growth factor (VEGF) is an important regulator of angiogenesis. Strong interindividual variations of VEGF plasma levels have been reported previously. Aim of the present study was to search for mutations in the 3' untranslated region (3'-UTR) of the VEGF gene and to analyze their relation to VEGF plasma levels.The complete 3'-UTR (nucleotide 700-2622) of the VEGF gene was screened for sequence variations by single-strand conformation polymorphism (SSCP) analysis. Frequencies of mutated alleles were determined in 119 healthy subjects; VEGF plasma levels were analyzed in a subgroup of 23 healthy men aged 18-36 years.Three novel mutations (702 C/T, 936 C/T, 1612 G/A) were found, allele frequencies of 702T, 936T and 1612A were of 0.017, 0.160 and 0.471, respectively. VEGF plasma levels were significantly lower in carriers of the 936T allele (9.1 +/- 2.7 pg/ml, mean +/- SEM) than in noncarriers (28.0 +/- 5.5 pg/ml, p = 0.033), whereas the 702 C/T and the 1612 G/A mutations showed no association with VEGF plasma levels. The 936 C/T exchange led to the loss of a potential binding site for transcription factor AP-4, although the functionality of this binding site remains unclear.We have found three common mutations in the VEGF gene; one of them, a 936 C/T exchange, may be an important determinant of VEGF plasma levels." @default.
- W2070244414 created "2016-06-24" @default.
- W2070244414 creator A5003612919 @default.
- W2070244414 creator A5026214775 @default.
- W2070244414 creator A5043082129 @default.
- W2070244414 creator A5073458525 @default.
- W2070244414 creator A5089537116 @default.
- W2070244414 date "2000-01-01" @default.
- W2070244414 modified "2023-10-18" @default.
- W2070244414 title "A Common 936 C/T Mutation in the Gene for Vascular Endothelial Growth Factor Is Associated with Vascular Endothelial Growth Factor Plasma Levels" @default.
- W2070244414 cites W1969442477 @default.
- W2070244414 cites W2031435841 @default.
- W2070244414 cites W2038750685 @default.
- W2070244414 cites W2045247659 @default.
- W2070244414 cites W2058562167 @default.
- W2070244414 cites W2059269241 @default.
- W2070244414 cites W2083107538 @default.
- W2070244414 cites W2121594719 @default.
- W2070244414 doi "https://doi.org/10.1159/000054076" @default.
- W2070244414 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11146397" @default.
- W2070244414 hasPublicationYear "2000" @default.
- W2070244414 type Work @default.
- W2070244414 sameAs 2070244414 @default.
- W2070244414 citedByCount "492" @default.
- W2070244414 countsByYear W20702444142012 @default.
- W2070244414 countsByYear W20702444142013 @default.
- W2070244414 countsByYear W20702444142014 @default.
- W2070244414 countsByYear W20702444142015 @default.
- W2070244414 countsByYear W20702444142016 @default.
- W2070244414 countsByYear W20702444142017 @default.
- W2070244414 countsByYear W20702444142018 @default.
- W2070244414 countsByYear W20702444142019 @default.
- W2070244414 countsByYear W20702444142020 @default.
- W2070244414 countsByYear W20702444142021 @default.
- W2070244414 countsByYear W20702444142022 @default.
- W2070244414 countsByYear W20702444142023 @default.
- W2070244414 crossrefType "journal-article" @default.
- W2070244414 hasAuthorship W2070244414A5003612919 @default.
- W2070244414 hasAuthorship W2070244414A5026214775 @default.
- W2070244414 hasAuthorship W2070244414A5043082129 @default.
- W2070244414 hasAuthorship W2070244414A5073458525 @default.
- W2070244414 hasAuthorship W2070244414A5089537116 @default.
- W2070244414 hasConcept C103041312 @default.
- W2070244414 hasConcept C104317684 @default.
- W2070244414 hasConcept C126322002 @default.
- W2070244414 hasConcept C129219603 @default.
- W2070244414 hasConcept C134018914 @default.
- W2070244414 hasConcept C135763542 @default.
- W2070244414 hasConcept C146285616 @default.
- W2070244414 hasConcept C153209595 @default.
- W2070244414 hasConcept C153911025 @default.
- W2070244414 hasConcept C167734588 @default.
- W2070244414 hasConcept C180754005 @default.
- W2070244414 hasConcept C2777025900 @default.
- W2070244414 hasConcept C2780394083 @default.
- W2070244414 hasConcept C501734568 @default.
- W2070244414 hasConcept C502942594 @default.
- W2070244414 hasConcept C54355233 @default.
- W2070244414 hasConcept C71924100 @default.
- W2070244414 hasConcept C86803240 @default.
- W2070244414 hasConceptScore W2070244414C103041312 @default.
- W2070244414 hasConceptScore W2070244414C104317684 @default.
- W2070244414 hasConceptScore W2070244414C126322002 @default.
- W2070244414 hasConceptScore W2070244414C129219603 @default.
- W2070244414 hasConceptScore W2070244414C134018914 @default.
- W2070244414 hasConceptScore W2070244414C135763542 @default.
- W2070244414 hasConceptScore W2070244414C146285616 @default.
- W2070244414 hasConceptScore W2070244414C153209595 @default.
- W2070244414 hasConceptScore W2070244414C153911025 @default.
- W2070244414 hasConceptScore W2070244414C167734588 @default.
- W2070244414 hasConceptScore W2070244414C180754005 @default.
- W2070244414 hasConceptScore W2070244414C2777025900 @default.
- W2070244414 hasConceptScore W2070244414C2780394083 @default.
- W2070244414 hasConceptScore W2070244414C501734568 @default.
- W2070244414 hasConceptScore W2070244414C502942594 @default.
- W2070244414 hasConceptScore W2070244414C54355233 @default.
- W2070244414 hasConceptScore W2070244414C71924100 @default.
- W2070244414 hasConceptScore W2070244414C86803240 @default.
- W2070244414 hasIssue "6" @default.
- W2070244414 hasLocation W20702444141 @default.
- W2070244414 hasLocation W20702444142 @default.
- W2070244414 hasOpenAccess W2070244414 @default.
- W2070244414 hasPrimaryLocation W20702444141 @default.
- W2070244414 hasRelatedWork W2009081283 @default.
- W2070244414 hasRelatedWork W2029619231 @default.
- W2070244414 hasRelatedWork W2034393061 @default.
- W2070244414 hasRelatedWork W2118989983 @default.
- W2070244414 hasRelatedWork W2151772280 @default.
- W2070244414 hasRelatedWork W2161808292 @default.
- W2070244414 hasRelatedWork W2318497614 @default.
- W2070244414 hasRelatedWork W2360943677 @default.
- W2070244414 hasRelatedWork W2940717530 @default.
- W2070244414 hasRelatedWork W3023870618 @default.
- W2070244414 hasVolume "37" @default.
- W2070244414 isParatext "false" @default.
- W2070244414 isRetracted "false" @default.
- W2070244414 magId "2070244414" @default.
- W2070244414 workType "article" @default.