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- W2070249582 abstract "The effect of chronic treatment with the angiotensin converting enzyme inhibitor, temocapril, on prevention of endothelial dysfunction was evaluated in an experimental model of diabetes mellitus. Endothelium-dependent relaxation to acetylcholine was impaired while endothelium-independent relaxation to nitroglycerin was unaltered in diabetic aortic ring segments. Treatment of diabetic animals with temocapril prevented the impaired endothelium-dependent relaxation without altering responses to nitroglycerin. Acetylcholine-induced relaxation was largely due to nitric oxide (NO)-mediated relaxation; however, a small but significant portion of relaxation in aortic rings from temocapril-treated diabetic rats was resistant to inhibition by the nitric oxide synthase (NOS) inhibitor, L-nitroarginine." @default.
- W2070249582 created "2016-06-24" @default.
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- W2070249582 date "2000-09-01" @default.
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- W2070249582 title "Temocapril, an angiotensin converting enzyme inhibitor, protects against diabetes-induced endothelial dysfunction" @default.
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- W2070249582 doi "https://doi.org/10.1016/s0014-2999(00)00508-2" @default.
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