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- W2070254703 abstract "Short-term cultures of bovine leukemic lymphocytes release virus particles with biochemical properties of RNA oncogenic viruses. These particles, tentatively called bovine leukemia virus (BLV), have a high molecular weight RNA-reverse transcriptase complex and a density of 1.155 g/ml in sucrose solutions. Molecular hybridizations between BLV/[3H]cDNA and several viral RNAs show that BLV is not related to Mason-Pfizer monkey virus, simian sarcoma associated virus, feline leukemia virus, or avian myeloblastosis virus. These results were confirmed by hybridization between BLV 70S RNA and [3H]cDNA synthesized in the various viruses tested. The high preference of BLV reverse transciptase for Mg++ as the divalent cation suggests that BLV might be an atypical mammalian leukemogenic type C virus. DNA-DNA hybridization studies using BLV [3H]cDNA as a probe strongly suggest that the DNA of bovine leukemic cells contains viral sequences that cannot be detected in normal bovine DNA." @default.
- W2070254703 created "2016-06-24" @default.
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- W2070254703 date "1976-04-01" @default.
- W2070254703 modified "2023-10-06" @default.
- W2070254703 title "Bovine leukemia virus: an exogenous RNA oncogenic virus." @default.
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- W2070254703 doi "https://doi.org/10.1073/pnas.73.4.1014" @default.
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