FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070255110> ?p ?o ?g. }

• W2070255110 endingPage "218" @default.
• W2070255110 startingPage "211" @default.
• W2070255110 abstract "The aim of this work was to detect allosteric hotspots signatures characterizing protein regions acting as the 'key drivers' of global allosteric conformational change. We computationally estimated the relative strength of intra-molecular interaction in allosteric proteins between two putative allostery-susceptible sites using a co-evolution model based upon the optimization of the cross-correlation in terms of free-energy-transfer hydrophobicity scale (Tanford scale) distribution along the chain. Cross-Recurrence Quantification Analysis (Cross-RQA) applied on the sequences of allostery susceptible sites showed evidence of strong interaction amongst allosteric susceptible sites. This could be due to transient weak molecular bonds between allostery susceptible patches enabling regions far-apart to come together. Further, using a large protein dataset, by comparing allosteric protein set with a randomly generated sequence population as well as a generic protein set, we reconfirmed our earlier findings that hydrophobicity patterning (as formalized by Recurrence Quantification Analysis (RQA) descriptors) may serve as determinant of allostery and its relevance in the transmission of allosteric conformational change. We applied RQA to free-energy-transfer hydrophobicity-transformed amino acid sequences of the allostery dataset to extract allostery specific global sequence features. These free-energy-transfer hydrophobicity-based RQA markers proved to be representative of allosteric signatures and not related to the differences between randomly generated and real proteins. These free-energy-transfer hydrophobicity-based RQA markers when evaluated by pattern recognition tools could distinguish allosteric proteins with 92% accuracy." @default.
• W2070255110 created "2016-06-24" @default.
• W2070255110 creator A5013428460 @default.
• W2070255110 creator A5049330559 @default.
• W2070255110 creator A5063865534 @default.
• W2070255110 creator A5079955221 @default.
• W2070255110 date "2012-07-01" @default.
• W2070255110 modified "2023-10-16" @default.
• W2070255110 title "Looking for a sequence based allostery definition: A statistical journey at different resolution scales" @default.
• W2070255110 cites W1551404386 @default.
• W2070255110 cites W1967095911 @default.
• W2070255110 cites W1967337826 @default.
• W2070255110 cites W1981224699 @default.
• W2070255110 cites W1982874561 @default.
• W2070255110 cites W1984391316 @default.
• W2070255110 cites W1984765576 @default.
• W2070255110 cites W1990374415 @default.
• W2070255110 cites W1992778133 @default.
• W2070255110 cites W1993160846 @default.
• W2070255110 cites W2000181436 @default.
• W2070255110 cites W2017428798 @default.
• W2070255110 cites W2021209514 @default.
• W2070255110 cites W2028529745 @default.
• W2070255110 cites W2048934130 @default.
• W2070255110 cites W2049682677 @default.
• W2070255110 cites W2050643839 @default.
• W2070255110 cites W2069082105 @default.
• W2070255110 cites W2071573423 @default.
• W2070255110 cites W2074129172 @default.
• W2070255110 cites W2080736062 @default.
• W2070255110 cites W2081681829 @default.
• W2070255110 cites W2092006899 @default.
• W2070255110 cites W2095420958 @default.
• W2070255110 cites W2098046028 @default.
• W2070255110 cites W2099593264 @default.
• W2070255110 cites W2105254477 @default.
• W2070255110 cites W2112703249 @default.
• W2070255110 cites W2125121305 @default.
• W2070255110 cites W2125852714 @default.
• W2070255110 cites W2129472062 @default.
• W2070255110 cites W2133161189 @default.
• W2070255110 cites W2145421684 @default.
• W2070255110 cites W2152738784 @default.
• W2070255110 cites W2153685275 @default.
• W2070255110 cites W2155891555 @default.
• W2070255110 cites W2160329145 @default.
• W2070255110 cites W2164831247 @default.
• W2070255110 cites W2165048399 @default.
• W2070255110 cites W2335043154 @default.
• W2070255110 doi "https://doi.org/10.1016/j.jtbi.2012.03.005" @default.
• W2070255110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22484347" @default.
• W2070255110 hasPublicationYear "2012" @default.
• W2070255110 type Work @default.
• W2070255110 sameAs 2070255110 @default.
• W2070255110 citedByCount "9" @default.
• W2070255110 countsByYear W20702551102013 @default.
• W2070255110 countsByYear W20702551102014 @default.
• W2070255110 countsByYear W20702551102015 @default.
• W2070255110 countsByYear W20702551102016 @default.
• W2070255110 countsByYear W20702551102017 @default.
• W2070255110 countsByYear W20702551102020 @default.
• W2070255110 crossrefType "journal-article" @default.
• W2070255110 hasAuthorship W2070255110A5013428460 @default.
• W2070255110 hasAuthorship W2070255110A5049330559 @default.
• W2070255110 hasAuthorship W2070255110A5063865534 @default.
• W2070255110 hasAuthorship W2070255110A5079955221 @default.
• W2070255110 hasConcept C121332964 @default.
• W2070255110 hasConcept C12554922 @default.
• W2070255110 hasConcept C144024400 @default.
• W2070255110 hasConcept C149923435 @default.
• W2070255110 hasConcept C158622935 @default.
• W2070255110 hasConcept C166342909 @default.
• W2070255110 hasConcept C181199279 @default.
• W2070255110 hasConcept C186060115 @default.
• W2070255110 hasConcept C2778112365 @default.
• W2070255110 hasConcept C2908647359 @default.
• W2070255110 hasConcept C43456602 @default.
• W2070255110 hasConcept C55493867 @default.
• W2070255110 hasConcept C62520636 @default.
• W2070255110 hasConcept C70721500 @default.
• W2070255110 hasConcept C86803240 @default.
• W2070255110 hasConceptScore W2070255110C121332964 @default.
• W2070255110 hasConceptScore W2070255110C12554922 @default.
• W2070255110 hasConceptScore W2070255110C144024400 @default.
• W2070255110 hasConceptScore W2070255110C149923435 @default.
• W2070255110 hasConceptScore W2070255110C158622935 @default.
• W2070255110 hasConceptScore W2070255110C166342909 @default.
• W2070255110 hasConceptScore W2070255110C181199279 @default.
• W2070255110 hasConceptScore W2070255110C186060115 @default.
• W2070255110 hasConceptScore W2070255110C2778112365 @default.
• W2070255110 hasConceptScore W2070255110C2908647359 @default.
• W2070255110 hasConceptScore W2070255110C43456602 @default.
• W2070255110 hasConceptScore W2070255110C55493867 @default.
• W2070255110 hasConceptScore W2070255110C62520636 @default.
• W2070255110 hasConceptScore W2070255110C70721500 @default.
• W2070255110 hasConceptScore W2070255110C86803240 @default.
• W2070255110 hasLocation W20702551101 @default.
• W2070255110 hasLocation W20702551102 @default.

• next