Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070277091> ?p ?o ?g. }
- W2070277091 endingPage "11" @default.
- W2070277091 startingPage "1" @default.
- W2070277091 abstract "In this study we show that high frequency stimulation (HFS, 100 Hz) of afferent fibers to the medial vestibular nucleus (MVN) can induce opposite long-term modifications of synaptic responses in the type B neurons depending upon the stimulation pattern. Long burst stimulation (LBS: 2 s) and short burst stimulation (SBS: 0.55 s) were applied with different burst number (BN) and inter-burst intervals (IBI). It results that both LBS and SBS can induce either N-methyl-d aspartate receptors (NMDARs)-mediated long-term potentiation (LTP) or long-term depression (LTD), depending on temporal organization of repetitive bursts. In particular, the IBI plays a relevant role in guiding the shift from LTP to LTD since by using both LBS and SBS LTP is induced by shorter IBI than LTD. By contrast, the sign of long-term effect does not depend on the mean impulse frequency evaluated within the entire stimulation period. Therefore, the patterns of repetitive vestibular activation with different ratios between periods of increased activity and periods of basal activity may lead to LTP or LTD probably causing different levels of postsynaptic Ca2+. On the whole, this study demonstrates that glutamatergic vestibular synapse in the MVN can undergo NMDAR-dependent bidirectional plasticity and puts forward a new aspect for understanding the adaptive and compensatory plasticity of the oculomotor responses." @default.
- W2070277091 created "2016-06-24" @default.
- W2070277091 creator A5020195488 @default.
- W2070277091 creator A5076005340 @default.
- W2070277091 creator A5079667356 @default.
- W2070277091 creator A5085506301 @default.
- W2070277091 date "2012-10-01" @default.
- W2070277091 modified "2023-09-30" @default.
- W2070277091 title "The repetition timing of high frequency afferent stimulation drives the bidirectional plasticity at central synapses in the rat medial vestibular nuclei" @default.
- W2070277091 cites W128738002 @default.
- W2070277091 cites W1484577487 @default.
- W2070277091 cites W1830097086 @default.
- W2070277091 cites W1930054580 @default.
- W2070277091 cites W1957331510 @default.
- W2070277091 cites W1965303728 @default.
- W2070277091 cites W1966004596 @default.
- W2070277091 cites W1974210875 @default.
- W2070277091 cites W1974496822 @default.
- W2070277091 cites W1974686327 @default.
- W2070277091 cites W1974816115 @default.
- W2070277091 cites W1976819021 @default.
- W2070277091 cites W1983698142 @default.
- W2070277091 cites W1984397875 @default.
- W2070277091 cites W1990374926 @default.
- W2070277091 cites W1993965993 @default.
- W2070277091 cites W1996250050 @default.
- W2070277091 cites W2004936885 @default.
- W2070277091 cites W2005828819 @default.
- W2070277091 cites W2007135500 @default.
- W2070277091 cites W2012303532 @default.
- W2070277091 cites W2014725799 @default.
- W2070277091 cites W2022621073 @default.
- W2070277091 cites W2023013885 @default.
- W2070277091 cites W2023715481 @default.
- W2070277091 cites W2024320179 @default.
- W2070277091 cites W2026896596 @default.
- W2070277091 cites W2027381798 @default.
- W2070277091 cites W2028120508 @default.
- W2070277091 cites W2028294757 @default.
- W2070277091 cites W2032023021 @default.
- W2070277091 cites W2032033482 @default.
- W2070277091 cites W2044729572 @default.
- W2070277091 cites W2047766053 @default.
- W2070277091 cites W2048030476 @default.
- W2070277091 cites W2063798305 @default.
- W2070277091 cites W2068334571 @default.
- W2070277091 cites W2074278757 @default.
- W2070277091 cites W2077758457 @default.
- W2070277091 cites W2078366352 @default.
- W2070277091 cites W2078430358 @default.
- W2070277091 cites W2079005033 @default.
- W2070277091 cites W2080778713 @default.
- W2070277091 cites W2082198705 @default.
- W2070277091 cites W2084133226 @default.
- W2070277091 cites W2095429612 @default.
- W2070277091 cites W2103164465 @default.
- W2070277091 cites W2103454167 @default.
- W2070277091 cites W2108712028 @default.
- W2070277091 cites W2110724392 @default.
- W2070277091 cites W2112465764 @default.
- W2070277091 cites W2120944389 @default.
- W2070277091 cites W2121466553 @default.
- W2070277091 cites W2129952903 @default.
- W2070277091 cites W2139883529 @default.
- W2070277091 cites W2167228285 @default.
- W2070277091 cites W2168553595 @default.
- W2070277091 cites W2168986469 @default.
- W2070277091 cites W2297631995 @default.
- W2070277091 cites W2340777212 @default.
- W2070277091 cites W2411543166 @default.
- W2070277091 cites W4238052420 @default.
- W2070277091 cites W4243080307 @default.
- W2070277091 doi "https://doi.org/10.1016/j.neuroscience.2012.07.039" @default.
- W2070277091 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22863673" @default.
- W2070277091 hasPublicationYear "2012" @default.
- W2070277091 type Work @default.
- W2070277091 sameAs 2070277091 @default.
- W2070277091 citedByCount "22" @default.
- W2070277091 countsByYear W20702770912013 @default.
- W2070277091 countsByYear W20702770912014 @default.
- W2070277091 countsByYear W20702770912015 @default.
- W2070277091 countsByYear W20702770912016 @default.
- W2070277091 countsByYear W20702770912017 @default.
- W2070277091 countsByYear W20702770912020 @default.
- W2070277091 countsByYear W20702770912021 @default.
- W2070277091 countsByYear W20702770912022 @default.
- W2070277091 countsByYear W20702770912023 @default.
- W2070277091 crossrefType "journal-article" @default.
- W2070277091 hasAuthorship W2070277091A5020195488 @default.
- W2070277091 hasAuthorship W2070277091A5076005340 @default.
- W2070277091 hasAuthorship W2070277091A5079667356 @default.
- W2070277091 hasAuthorship W2070277091A5085506301 @default.
- W2070277091 hasConcept C112592302 @default.
- W2070277091 hasConcept C118232355 @default.
- W2070277091 hasConcept C127445978 @default.
- W2070277091 hasConcept C160268369 @default.
- W2070277091 hasConcept C169760540 @default.
- W2070277091 hasConcept C170493617 @default.