Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070287777> ?p ?o ?g. }
- W2070287777 endingPage "47" @default.
- W2070287777 startingPage "37" @default.
- W2070287777 abstract "There is now a large volume of data indicating that compounds activating cannabinoid CB1 receptors, either directly or indirectly by preventing the breakdown of endogenous cannabinoids, can protect against neuronal damage produced by a variety of neuronal “insults”. Given that such neurodegenerative stimuli result in increased endocannabinoid levels and that animals with genetic deletions of CB1 receptors are more susceptible to the deleterious effects of such stimuli, a case can be made for an endogenous neuroprotective role of endocannabinoids. However, this is an oversimplification of the current literature, since (a) compounds released together with the endocannabinoids can contribute to the neuroprotective effect; (b) other proteins, such as TASK-1 and PPARα, are involved; (c) the CB1 receptor antagonist/inverse agonist rimonabant has also been reported to have neuroprotective properties in a number of animal models of neurodegenerative disorders. Furthermore, the CB2 receptor located on peripheral immune cells and activated microglia are potential targets for novel therapies. In terms of the clinical usefulness of targeting the endocannabinoid system for the treatment of neurodegenerative disorders, data are emerging, but important factors to be considered are windows of opportunity (for acute situations such as trauma and ischemia) and the functionality of the target receptors (for chronic neurodegenerative disorders such as Alzheimer's disease)." @default.
- W2070287777 created "2016-06-24" @default.
- W2070287777 creator A5005893002 @default.
- W2070287777 creator A5021985550 @default.
- W2070287777 creator A5068761485 @default.
- W2070287777 date "2010-07-01" @default.
- W2070287777 modified "2023-09-27" @default.
- W2070287777 title "Modulation of the endocannabinoid system: Neuroprotection or neurotoxicity?" @default.
- W2070287777 cites W1495173924 @default.
- W2070287777 cites W1506133305 @default.
- W2070287777 cites W1506884824 @default.
- W2070287777 cites W1529806277 @default.
- W2070287777 cites W1556923935 @default.
- W2070287777 cites W1558851717 @default.
- W2070287777 cites W1559076309 @default.
- W2070287777 cites W1579877956 @default.
- W2070287777 cites W1790460690 @default.
- W2070287777 cites W1843717323 @default.
- W2070287777 cites W1858969988 @default.
- W2070287777 cites W1876729781 @default.
- W2070287777 cites W1928757774 @default.
- W2070287777 cites W1929488495 @default.
- W2070287777 cites W1964395752 @default.
- W2070287777 cites W1966440880 @default.
- W2070287777 cites W1967493869 @default.
- W2070287777 cites W1967558194 @default.
- W2070287777 cites W1968740815 @default.
- W2070287777 cites W1968881526 @default.
- W2070287777 cites W1969979466 @default.
- W2070287777 cites W1970047009 @default.
- W2070287777 cites W1971442479 @default.
- W2070287777 cites W1972655404 @default.
- W2070287777 cites W1972820094 @default.
- W2070287777 cites W1976127510 @default.
- W2070287777 cites W1977976049 @default.
- W2070287777 cites W1979519364 @default.
- W2070287777 cites W1981323788 @default.
- W2070287777 cites W1983546073 @default.
- W2070287777 cites W1983701850 @default.
- W2070287777 cites W1989155012 @default.
- W2070287777 cites W1990213581 @default.
- W2070287777 cites W1991938120 @default.
- W2070287777 cites W1992758695 @default.
- W2070287777 cites W1993339524 @default.
- W2070287777 cites W1994127033 @default.
- W2070287777 cites W1999113156 @default.
- W2070287777 cites W1999822120 @default.
- W2070287777 cites W2001276618 @default.
- W2070287777 cites W2003661559 @default.
- W2070287777 cites W2005828463 @default.
- W2070287777 cites W2006474138 @default.
- W2070287777 cites W2007578821 @default.
- W2070287777 cites W2009863960 @default.
- W2070287777 cites W2010535402 @default.
- W2070287777 cites W2010665440 @default.
- W2070287777 cites W2011142394 @default.
- W2070287777 cites W2014266143 @default.
- W2070287777 cites W2015264989 @default.
- W2070287777 cites W2016322530 @default.
- W2070287777 cites W2016821576 @default.
- W2070287777 cites W2018003279 @default.
- W2070287777 cites W2020678194 @default.
- W2070287777 cites W2024122340 @default.
- W2070287777 cites W2024782047 @default.
- W2070287777 cites W2028794471 @default.
- W2070287777 cites W2031111076 @default.
- W2070287777 cites W2032715817 @default.
- W2070287777 cites W2034266460 @default.
- W2070287777 cites W2038487696 @default.
- W2070287777 cites W2041074139 @default.
- W2070287777 cites W2042500607 @default.
- W2070287777 cites W2043033522 @default.
- W2070287777 cites W2044784707 @default.
- W2070287777 cites W2045422180 @default.
- W2070287777 cites W2046392540 @default.
- W2070287777 cites W2050453710 @default.
- W2070287777 cites W2051086257 @default.
- W2070287777 cites W2051554315 @default.
- W2070287777 cites W2051811620 @default.
- W2070287777 cites W2053071162 @default.
- W2070287777 cites W2055309785 @default.
- W2070287777 cites W2055572770 @default.
- W2070287777 cites W2055577040 @default.
- W2070287777 cites W2055843185 @default.
- W2070287777 cites W2058955046 @default.
- W2070287777 cites W2065987181 @default.
- W2070287777 cites W2066448413 @default.
- W2070287777 cites W2066504268 @default.
- W2070287777 cites W2069460649 @default.
- W2070287777 cites W2070834797 @default.
- W2070287777 cites W2071043497 @default.
- W2070287777 cites W2076644438 @default.
- W2070287777 cites W2077264392 @default.
- W2070287777 cites W2077978700 @default.
- W2070287777 cites W2078288123 @default.
- W2070287777 cites W2078495330 @default.
- W2070287777 cites W2080185710 @default.
- W2070287777 cites W2080282837 @default.