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- W2070290044 abstract "The receptors for members of the relaxin peptide family have only recently been discovered and are G-protein-coupled receptors (GPCRs). Relaxin and insulin-like peptide 3 (INSL3) interact with the leucine-rich-repeat-containing GPCRs (LGRs) LGR7 and LGR8, respectively. These receptors show closest similarity to the glycoprotein hormone receptors and contain large ectodomains with 10 leucine-rich repeats (LRRs) but are unique members of the LGR family (class C) as they have an LDL class A (LDLa) module at their N-terminus. In contrast, relaxin-3 and INSL5 interact with another class of type I GPCRs which lack a large ectodomain, the peptide receptors GPCR135 and GPCR142, respectively. These receptors are now classified as relaxin family peptide (RXFP) receptors, RXFP1 (LGR7), RXFP2 (LGR8), RXFP3 (GPCR135) and RXFP4 (GPCR142). This review outlines the identification of the peptides and receptors, their expression profiles and physiological roles and the functional interactions of the peptides with their unique receptors." @default.
- W2070290044 created "2016-06-24" @default.
- W2070290044 creator A5004202732 @default.
- W2070290044 creator A5013996048 @default.
- W2070290044 creator A5023360012 @default.
- W2070290044 creator A5071595654 @default.
- W2070290044 creator A5074997845 @default.
- W2070290044 date "2010-05-01" @default.
- W2070290044 modified "2023-10-12" @default.
- W2070290044 title "Membrane receptors: Structure and function of the relaxin family peptide receptors" @default.
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