FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070290557> ?p ?o ?g. }

• W2070290557 endingPage "234" @default.
• W2070290557 startingPage "226" @default.
• W2070290557 abstract "The role of inflammatory effector cells in the pathogenesis of airway allergy has been the subject of much investigation. However, whether systemic factors are involved in the development of local responses in both upper and lower airways has not been fully clarified. The present study was performed to investigate aspects of the pathogenesis of isolated allergic rhinitis in a murine model sensitized to ovalbumin (OVA). Both upper- and lower-airway physiological responsiveness and inflammatory changes were assessed, as well as bone marrow progenitor responses, by culture and immunohistological methods. Significant nasal symptoms and hyper-responsiveness appeared after intranasal OVA challenge (P < 0.0001 and P < 0.01, respectively), accompanied with significant nasal mucosal changes in CD4+ cells (P < 0.001), interleukin (IL)-4+ cells (P < 0.01), IL-5+ cells (P < 0.01), basophilic cells (P < 0.02) and eosinophils (P < 0.001), in the complete absence of hyper-responsiveness or inflammatory changes in the lower airway. In the bone marrow, there were significant increases in CD34+ cells, as well as in eosinophils and basophilic cells. In the presence in vitro of mouse recombinant IL-5, IL-3 or granulocyte-macrophage colony-stimulating factor (GM-CSF), the level of bone marrow eosinophil/basophil (Eo/Baso) colony-forming cells increased significantly in the OVA-sensitized group. We conclude that, in this murine model of allergic rhinitis, haemopoietic progenitors are upregulated, which is consistent with the involvement of bone marrow in the pathogenesis of nasal mucosal inflammation. Both local and systemic events, initiated in response to allergen provocation, may be required for the pathogenesis of allergic rhinitis. Understanding these events and their regulation could provide new therapeutic targets for rhinitis and asthma." @default.
• W2070290557 created "2016-06-24" @default.
• W2070290557 creator A5002637822 @default.
• W2070290557 creator A5024670665 @default.
• W2070290557 creator A5026550581 @default.
• W2070290557 creator A5057545023 @default.
• W2070290557 creator A5060383332 @default.
• W2070290557 creator A5077189765 @default.
• W2070290557 creator A5089734602 @default.
• W2070290557 date "2001-10-01" @default.
• W2070290557 modified "2023-09-26" @default.
• W2070290557 title "Allergen-induced murine upper airway inflammation: local and systemic changes in murine experimental allergic rhinitis" @default.
• W2070290557 cites W1974702881 @default.
• W2070290557 cites W1977014326 @default.
• W2070290557 cites W1979121858 @default.
• W2070290557 cites W1995104897 @default.
• W2070290557 cites W1997617355 @default.
• W2070290557 cites W1999569539 @default.
• W2070290557 cites W2001482867 @default.
• W2070290557 cites W2008761793 @default.
• W2070290557 cites W2009999055 @default.
• W2070290557 cites W2010125040 @default.
• W2070290557 cites W2013432909 @default.
• W2070290557 cites W2022500783 @default.
• W2070290557 cites W2026112917 @default.
• W2070290557 cites W2031256138 @default.
• W2070290557 cites W2034826344 @default.
• W2070290557 cites W2042285142 @default.
• W2070290557 cites W2055235480 @default.
• W2070290557 cites W2056476229 @default.
• W2070290557 cites W2060155836 @default.
• W2070290557 cites W2078646546 @default.
• W2070290557 cites W2083902867 @default.
• W2070290557 cites W2084432094 @default.
• W2070290557 cites W2087644006 @default.
• W2070290557 cites W2088685932 @default.
• W2070290557 cites W2089187619 @default.
• W2070290557 cites W2091275796 @default.
• W2070290557 cites W2095520848 @default.
• W2070290557 cites W2101529474 @default.
• W2070290557 cites W2104174070 @default.
• W2070290557 cites W2132754264 @default.
• W2070290557 cites W2145070315 @default.
• W2070290557 cites W2416534619 @default.
• W2070290557 cites W2417416204 @default.
• W2070290557 cites W4581848 @default.
• W2070290557 doi "https://doi.org/10.1046/j.1365-2567.2001.01253.x" @default.
• W2070290557 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1783291" @default.
• W2070290557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11683963" @default.
• W2070290557 hasPublicationYear "2001" @default.
• W2070290557 type Work @default.
• W2070290557 sameAs 2070290557 @default.
• W2070290557 citedByCount "77" @default.
• W2070290557 countsByYear W20702905572012 @default.
• W2070290557 countsByYear W20702905572013 @default.
• W2070290557 countsByYear W20702905572014 @default.
• W2070290557 countsByYear W20702905572015 @default.
• W2070290557 countsByYear W20702905572016 @default.
• W2070290557 countsByYear W20702905572017 @default.
• W2070290557 countsByYear W20702905572019 @default.
• W2070290557 crossrefType "journal-article" @default.
• W2070290557 hasAuthorship W2070290557A5002637822 @default.
• W2070290557 hasAuthorship W2070290557A5024670665 @default.
• W2070290557 hasAuthorship W2070290557A5026550581 @default.
• W2070290557 hasAuthorship W2070290557A5057545023 @default.
• W2070290557 hasAuthorship W2070290557A5060383332 @default.
• W2070290557 hasAuthorship W2070290557A5077189765 @default.
• W2070290557 hasAuthorship W2070290557A5089734602 @default.
• W2070290557 hasConcept C141105273 @default.
• W2070290557 hasConcept C142724271 @default.
• W2070290557 hasConcept C159654299 @default.
• W2070290557 hasConcept C19210678 @default.
• W2070290557 hasConcept C203014093 @default.
• W2070290557 hasConcept C207480886 @default.
• W2070290557 hasConcept C2776042228 @default.
• W2070290557 hasConcept C2776051438 @default.
• W2070290557 hasConcept C2776914184 @default.
• W2070290557 hasConcept C2776946954 @default.
• W2070290557 hasConcept C2777037409 @default.
• W2070290557 hasConcept C2777456892 @default.
• W2070290557 hasConcept C2777983669 @default.
• W2070290557 hasConcept C2778170410 @default.
• W2070290557 hasConcept C2779675166 @default.
• W2070290557 hasConcept C2780007613 @default.
• W2070290557 hasConcept C2780942790 @default.
• W2070290557 hasConcept C71924100 @default.
• W2070290557 hasConcept C8891405 @default.
• W2070290557 hasConceptScore W2070290557C141105273 @default.
• W2070290557 hasConceptScore W2070290557C142724271 @default.
• W2070290557 hasConceptScore W2070290557C159654299 @default.
• W2070290557 hasConceptScore W2070290557C19210678 @default.
• W2070290557 hasConceptScore W2070290557C203014093 @default.
• W2070290557 hasConceptScore W2070290557C207480886 @default.
• W2070290557 hasConceptScore W2070290557C2776042228 @default.
• W2070290557 hasConceptScore W2070290557C2776051438 @default.
• W2070290557 hasConceptScore W2070290557C2776914184 @default.
• W2070290557 hasConceptScore W2070290557C2776946954 @default.
• W2070290557 hasConceptScore W2070290557C2777037409 @default.

• next