FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070290732> ?p ?o ?g. }

• W2070290732 abstract "Many cellular constituents travel along microtubules in association with multiple copies of motor proteins. How the activity of these motors is regulated during cargo sorting is poorly understood. In this study, we address this issue using a novel in vitro assay for the motility of localising Drosophila mRNAs bound to native dynein-dynactin complexes. High precision tracking reveals that individual RNPs within a population undergo either diffusive, or highly processive, minus end-directed movements along microtubules. RNA localisation signals stimulate the processive movements, with regulation of dynein-dynactin's activity rather than its total copy number per RNP, responsible for this effect. Our data support a novel mechanism for multi-motor translocation based on the regulation of dynein processivity by discrete cargo-associated features. Studying the in vitro responses of RNPs to microtubule-associated proteins (MAPs) and microtubule ends provides insights into how an RNA population could navigate the cytoskeletal network and become anchored at its destination in cells. DOI: http://dx.doi.org/10.7554/eLife.01596.001." @default.
• W2070290732 created "2016-06-24" @default.
• W2070290732 creator A5038425294 @default.
• W2070290732 creator A5067739431 @default.
• W2070290732 date "2014-04-15" @default.
• W2070290732 modified "2023-09-27" @default.
• W2070290732 title "The influence of dynein processivity control, MAPs, and microtubule ends on directional movement of a localising mRNA" @default.
• W2070290732 cites W110087793 @default.
• W2070290732 cites W1509571186 @default.
• W2070290732 cites W1556700452 @default.
• W2070290732 cites W1596697122 @default.
• W2070290732 cites W1607350784 @default.
• W2070290732 cites W1963489221 @default.
• W2070290732 cites W1963597564 @default.
• W2070290732 cites W1963863239 @default.
• W2070290732 cites W1965151798 @default.
• W2070290732 cites W1966086662 @default.
• W2070290732 cites W1970866062 @default.
• W2070290732 cites W1972398314 @default.
• W2070290732 cites W1978135281 @default.
• W2070290732 cites W1978534363 @default.
• W2070290732 cites W1978950863 @default.
• W2070290732 cites W1979030771 @default.
• W2070290732 cites W1981662243 @default.
• W2070290732 cites W1982743797 @default.
• W2070290732 cites W1984618686 @default.
• W2070290732 cites W1989933605 @default.
• W2070290732 cites W1993356393 @default.
• W2070290732 cites W1993453384 @default.
• W2070290732 cites W1994529490 @default.
• W2070290732 cites W1996110246 @default.
• W2070290732 cites W1998246365 @default.
• W2070290732 cites W2000479770 @default.
• W2070290732 cites W2000536145 @default.
• W2070290732 cites W2008499498 @default.
• W2070290732 cites W2010366657 @default.
• W2070290732 cites W2015229379 @default.
• W2070290732 cites W2017168812 @default.
• W2070290732 cites W2022214576 @default.
• W2070290732 cites W2024677399 @default.
• W2070290732 cites W2027532748 @default.
• W2070290732 cites W2030874893 @default.
• W2070290732 cites W2033859483 @default.
• W2070290732 cites W2036719198 @default.
• W2070290732 cites W2037091801 @default.
• W2070290732 cites W2037981058 @default.
• W2070290732 cites W2038819923 @default.
• W2070290732 cites W2039273064 @default.
• W2070290732 cites W2040563603 @default.
• W2070290732 cites W2043447781 @default.
• W2070290732 cites W2044730950 @default.
• W2070290732 cites W2046118382 @default.
• W2070290732 cites W2048921995 @default.
• W2070290732 cites W2050873080 @default.
• W2070290732 cites W2051958637 @default.
• W2070290732 cites W2054165784 @default.
• W2070290732 cites W2056707942 @default.
• W2070290732 cites W2064173101 @default.
• W2070290732 cites W2067432764 @default.
• W2070290732 cites W2067633612 @default.
• W2070290732 cites W2068989347 @default.
• W2070290732 cites W2080096618 @default.
• W2070290732 cites W2085796374 @default.
• W2070290732 cites W2090047847 @default.
• W2070290732 cites W2094071037 @default.
• W2070290732 cites W2098889694 @default.
• W2070290732 cites W2102345134 @default.
• W2070290732 cites W2110488004 @default.
• W2070290732 cites W2119295924 @default.
• W2070290732 cites W2122261008 @default.
• W2070290732 cites W2128625390 @default.
• W2070290732 cites W2128843230 @default.
• W2070290732 cites W2130379504 @default.
• W2070290732 cites W2132550454 @default.
• W2070290732 cites W2135012523 @default.
• W2070290732 cites W2137262057 @default.
• W2070290732 cites W2138107120 @default.
• W2070290732 cites W2140836665 @default.
• W2070290732 cites W2147764280 @default.
• W2070290732 cites W2148038204 @default.
• W2070290732 cites W2149090615 @default.
• W2070290732 cites W2152399358 @default.
• W2070290732 cites W2153958514 @default.
• W2070290732 cites W2160226734 @default.
• W2070290732 cites W2160708064 @default.
• W2070290732 cites W2162710244 @default.
• W2070290732 cites W2162897213 @default.
• W2070290732 cites W2163174294 @default.
• W2070290732 cites W2165237971 @default.
• W2070290732 cites W2170133492 @default.
• W2070290732 cites W2170991710 @default.
• W2070290732 cites W2171061283 @default.
• W2070290732 doi "https://doi.org/10.7554/elife.01596" @default.
• W2070290732 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3985186" @default.
• W2070290732 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24737859" @default.
• W2070290732 hasPublicationYear "2014" @default.
• W2070290732 type Work @default.
• W2070290732 sameAs 2070290732 @default.
• W2070290732 citedByCount "47" @default.
• W2070290732 countsByYear W20702907322014 @default.

• next