FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070290847> ?p ?o ?g. }

• W2070290847 endingPage "1155" @default.
• W2070290847 startingPage "1143" @default.
• W2070290847 abstract "Molecular clones of HIV-1 were obtained from isolates cultured from peripheral blood mononuclear cells (PBMCs) and directly from uncultured PBMCs from a laboratory worker accidentally infected with the HIV-1 laboratory strain, HIV-1(HTLV-IIIB). Envelope sequences corresponding to the first 752 amino acids of HIV-1(HTLV-IIIB) clone BH10 were obtained from clones of cultured virus and sequenced. Three env clones obtained shortly after infection differed among themselves at only seven nucleotide positions, resulting in one amino acid substitution and one frameshift mutation. These envelope sequences were as similar to the envelope sequences of various IIIB clones as the latter were to each other, env divergence increased over the course of infection. However, the overall diversity in env clones obtained two or more years after infection was still comparable to that among IIIB env clones from the original IIIB culture. Multiple clones of partial env gene sequences containing the V3 loop were also obtained directly from uncultured PBMCs by polymerase chain reaction amplification. The env sequences of these clones were generally similar to those of the cultured viruses. Within the V3 region, the earliest isolates retained the sequence of the HXB2 clone from IIIB. Clones obtained later showed a progressive divergence in V3. An A-to-T substitution within the GPGRAF sequence at the tip of the V3 loop was observed within 1 year after infection, and this mutation predominated in all subsequent isolates. Antibodies against the V3 loops of IIIB and divergent 1987 and 1990 LW isolates appeared simultaneously in laboratory worker serum and persisted with no significant differences in titer. Furthermore, neutralization studies with autologous sequential sera suggested selection for the A-to-T change in V3 was not due to V3-directed antibodies. These results demonstrate a surprising homogeneity among env sequences of HIV-1 from an infected laboratory worker, perhaps because the initial infection originated from a relatively homogeneous population of tissue culture-adapted virus." @default.
• W2070290847 created "2016-06-24" @default.
• W2070290847 creator A5005216146 @default.
• W2070290847 creator A5006749029 @default.
• W2070290847 creator A5014091726 @default.
• W2070290847 creator A5015468056 @default.
• W2070290847 creator A5016075413 @default.
• W2070290847 creator A5039473114 @default.
• W2070290847 creator A5049737526 @default.
• W2070290847 creator A5067964875 @default.
• W2070290847 creator A5071707413 @default.
• W2070290847 creator A5073490871 @default.
• W2070290847 creator A5076586601 @default.
• W2070290847 date "1994-09-01" @default.
• W2070290847 modified "2023-09-27" @default.
• W2070290847 title "Viral Variability and Serum Antibody Response in a Laboratory Worker Infected with HIV Type 1 (HTLV Type IIIB)" @default.
• W2070290847 cites W1545937600 @default.
• W2070290847 cites W1558015274 @default.
• W2070290847 cites W1568767105 @default.
• W2070290847 cites W1838949111 @default.
• W2070290847 cites W1890058237 @default.
• W2070290847 cites W1900041373 @default.
• W2070290847 cites W1920272357 @default.
• W2070290847 cites W1970564514 @default.
• W2070290847 cites W1973013569 @default.
• W2070290847 cites W1974138678 @default.
• W2070290847 cites W1974261771 @default.
• W2070290847 cites W1981026726 @default.
• W2070290847 cites W1990765234 @default.
• W2070290847 cites W1991670386 @default.
• W2070290847 cites W1994019769 @default.
• W2070290847 cites W1996802981 @default.
• W2070290847 cites W2010426852 @default.
• W2070290847 cites W2014317403 @default.
• W2070290847 cites W2021984449 @default.
• W2070290847 cites W2030017358 @default.
• W2070290847 cites W2037793240 @default.
• W2070290847 cites W2053037116 @default.
• W2070290847 cites W2053667638 @default.
• W2070290847 cites W2058256613 @default.
• W2070290847 cites W2068490834 @default.
• W2070290847 cites W2069761065 @default.
• W2070290847 cites W2073511157 @default.
• W2070290847 cites W2081347192 @default.
• W2070290847 cites W2110917275 @default.
• W2070290847 cites W2112967927 @default.
• W2070290847 cites W2114279162 @default.
• W2070290847 cites W2127552260 @default.
• W2070290847 cites W2132674999 @default.
• W2070290847 cites W2137966586 @default.
• W2070290847 cites W2138270253 @default.
• W2070290847 cites W2156178056 @default.
• W2070290847 cites W2158658433 @default.
• W2070290847 cites W2318770038 @default.
• W2070290847 cites W2323021547 @default.
• W2070290847 doi "https://doi.org/10.1089/aid.1994.10.1143" @default.
• W2070290847 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7826699" @default.
• W2070290847 hasPublicationYear "1994" @default.
• W2070290847 type Work @default.
• W2070290847 sameAs 2070290847 @default.
• W2070290847 citedByCount "29" @default.
• W2070290847 countsByYear W20702908472014 @default.
• W2070290847 countsByYear W20702908472021 @default.
• W2070290847 crossrefType "journal-article" @default.
• W2070290847 hasAuthorship W2070290847A5005216146 @default.
• W2070290847 hasAuthorship W2070290847A5006749029 @default.
• W2070290847 hasAuthorship W2070290847A5014091726 @default.
• W2070290847 hasAuthorship W2070290847A5015468056 @default.
• W2070290847 hasAuthorship W2070290847A5016075413 @default.
• W2070290847 hasAuthorship W2070290847A5039473114 @default.
• W2070290847 hasAuthorship W2070290847A5049737526 @default.
• W2070290847 hasAuthorship W2070290847A5067964875 @default.
• W2070290847 hasAuthorship W2070290847A5071707413 @default.
• W2070290847 hasAuthorship W2070290847A5073490871 @default.
• W2070290847 hasAuthorship W2070290847A5076586601 @default.
• W2070290847 hasConcept C102906071 @default.
• W2070290847 hasConcept C104317684 @default.
• W2070290847 hasConcept C137061746 @default.
• W2070290847 hasConcept C141231307 @default.
• W2070290847 hasConcept C153911025 @default.
• W2070290847 hasConcept C159047783 @default.
• W2070290847 hasConcept C159654299 @default.
• W2070290847 hasConcept C167625842 @default.
• W2070290847 hasConcept C202751555 @default.
• W2070290847 hasConcept C2522874641 @default.
• W2070290847 hasConcept C2779921545 @default.
• W2070290847 hasConcept C29906990 @default.
• W2070290847 hasConcept C49105822 @default.
• W2070290847 hasConcept C501734568 @default.
• W2070290847 hasConcept C54355233 @default.
• W2070290847 hasConcept C81089528 @default.
• W2070290847 hasConcept C84148353 @default.
• W2070290847 hasConcept C86803240 @default.
• W2070290847 hasConcept C97380033 @default.
• W2070290847 hasConceptScore W2070290847C102906071 @default.
• W2070290847 hasConceptScore W2070290847C104317684 @default.
• W2070290847 hasConceptScore W2070290847C137061746 @default.
• W2070290847 hasConceptScore W2070290847C141231307 @default.

• next