Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070291200> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2070291200 endingPage "329" @default.
- W2070291200 startingPage "326" @default.
- W2070291200 abstract "Interruption of TGFβ signaling through inhibition of the TGFβR1 kinase domain may prove to have beneficial effect in both fibrotic and oncological diseases. Herein we describe the SAR of a novel series of TGFβR1 kinase inhibitors containing a pyrazolone core. Most TGFβR1 kinase inhibitors described to date contain a core five-membered ring bearing N as H-bond acceptor. Described herein is a novel strategy to replace the core structure with pyrazolone ring, in which the carbonyl group is designed as an H-bond acceptor to interact with catalytic Lys 232." @default.
- W2070291200 created "2016-06-24" @default.
- W2070291200 creator A5017789289 @default.
- W2070291200 creator A5037091443 @default.
- W2070291200 creator A5041806802 @default.
- W2070291200 creator A5043422189 @default.
- W2070291200 creator A5052339827 @default.
- W2070291200 creator A5058003328 @default.
- W2070291200 creator A5063754200 @default.
- W2070291200 creator A5067040049 @default.
- W2070291200 creator A5075436982 @default.
- W2070291200 creator A5078094200 @default.
- W2070291200 creator A5083976911 @default.
- W2070291200 date "2010-01-01" @default.
- W2070291200 modified "2023-09-26" @default.
- W2070291200 title "Pyrazolone based TGFβR1 kinase inhibitors" @default.
- W2070291200 cites W1984162437 @default.
- W2070291200 cites W2015959969 @default.
- W2070291200 cites W2039275948 @default.
- W2070291200 cites W2044600667 @default.
- W2070291200 cites W2078288720 @default.
- W2070291200 cites W2102548815 @default.
- W2070291200 cites W2163797065 @default.
- W2070291200 cites W2167504764 @default.
- W2070291200 doi "https://doi.org/10.1016/j.bmcl.2009.10.108" @default.
- W2070291200 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19914068" @default.
- W2070291200 hasPublicationYear "2010" @default.
- W2070291200 type Work @default.
- W2070291200 sameAs 2070291200 @default.
- W2070291200 citedByCount "23" @default.
- W2070291200 countsByYear W20702912002012 @default.
- W2070291200 countsByYear W20702912002013 @default.
- W2070291200 countsByYear W20702912002014 @default.
- W2070291200 countsByYear W20702912002015 @default.
- W2070291200 countsByYear W20702912002016 @default.
- W2070291200 countsByYear W20702912002017 @default.
- W2070291200 countsByYear W20702912002018 @default.
- W2070291200 countsByYear W20702912002019 @default.
- W2070291200 countsByYear W20702912002020 @default.
- W2070291200 countsByYear W20702912002021 @default.
- W2070291200 crossrefType "journal-article" @default.
- W2070291200 hasAuthorship W2070291200A5017789289 @default.
- W2070291200 hasAuthorship W2070291200A5037091443 @default.
- W2070291200 hasAuthorship W2070291200A5041806802 @default.
- W2070291200 hasAuthorship W2070291200A5043422189 @default.
- W2070291200 hasAuthorship W2070291200A5052339827 @default.
- W2070291200 hasAuthorship W2070291200A5058003328 @default.
- W2070291200 hasAuthorship W2070291200A5063754200 @default.
- W2070291200 hasAuthorship W2070291200A5067040049 @default.
- W2070291200 hasAuthorship W2070291200A5075436982 @default.
- W2070291200 hasAuthorship W2070291200A5078094200 @default.
- W2070291200 hasAuthorship W2070291200A5083976911 @default.
- W2070291200 hasConcept C121332964 @default.
- W2070291200 hasConcept C178790620 @default.
- W2070291200 hasConcept C181199279 @default.
- W2070291200 hasConcept C184235292 @default.
- W2070291200 hasConcept C185592680 @default.
- W2070291200 hasConcept C21951064 @default.
- W2070291200 hasConcept C26873012 @default.
- W2070291200 hasConcept C2778802955 @default.
- W2070291200 hasConcept C2779892579 @default.
- W2070291200 hasConcept C2780378348 @default.
- W2070291200 hasConcept C55493867 @default.
- W2070291200 hasConcept C71240020 @default.
- W2070291200 hasConceptScore W2070291200C121332964 @default.
- W2070291200 hasConceptScore W2070291200C178790620 @default.
- W2070291200 hasConceptScore W2070291200C181199279 @default.
- W2070291200 hasConceptScore W2070291200C184235292 @default.
- W2070291200 hasConceptScore W2070291200C185592680 @default.
- W2070291200 hasConceptScore W2070291200C21951064 @default.
- W2070291200 hasConceptScore W2070291200C26873012 @default.
- W2070291200 hasConceptScore W2070291200C2778802955 @default.
- W2070291200 hasConceptScore W2070291200C2779892579 @default.
- W2070291200 hasConceptScore W2070291200C2780378348 @default.
- W2070291200 hasConceptScore W2070291200C55493867 @default.
- W2070291200 hasConceptScore W2070291200C71240020 @default.
- W2070291200 hasIssue "1" @default.
- W2070291200 hasLocation W20702912001 @default.
- W2070291200 hasLocation W20702912002 @default.
- W2070291200 hasOpenAccess W2070291200 @default.
- W2070291200 hasPrimaryLocation W20702912001 @default.
- W2070291200 hasRelatedWork W2000745848 @default.
- W2070291200 hasRelatedWork W2118875098 @default.
- W2070291200 hasRelatedWork W2162041534 @default.
- W2070291200 hasRelatedWork W2357498109 @default.
- W2070291200 hasRelatedWork W2950387105 @default.
- W2070291200 hasRelatedWork W2951777384 @default.
- W2070291200 hasRelatedWork W2952294194 @default.
- W2070291200 hasRelatedWork W2952796142 @default.
- W2070291200 hasRelatedWork W4285270666 @default.
- W2070291200 hasRelatedWork W2020003695 @default.
- W2070291200 hasVolume "20" @default.
- W2070291200 isParatext "false" @default.
- W2070291200 isRetracted "false" @default.
- W2070291200 magId "2070291200" @default.
- W2070291200 workType "article" @default.