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• W2070291516 abstract "To characterize a necrotic lesion using MRI and motor recovery using behavioural methods.Stroke model based on two steps: (1) development of a lesion using MR-imaging parameters and (2) behavioural recovery.Seventy male Sprague-Dawley rats were used. A focal lesion of the right sensorimotor cortex was induced photochemically.The maximum volume of oedema and the lesion damage was reached by approximately 6 hours. In the lesion area, the apparent diffusion coefficient (ADC) increased from 6 hours, then decreased from 24 hours. All animals spontaneously recovered motor function by day 10, despite the continued presence of the cortical lesion.The results show that this model mimics a core lesion, as well as the late phase in a human stroke episode. This model might be used for longitudinal study of the basic mechanisms of motor recovery." @default.
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• W2070291516 date "2003-01-01" @default.
• W2070291516 modified "2023-09-30" @default.
• W2070291516 title "Behavioural recovery correlated with MRI in a rat experimental stroke model" @default.
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• W2070291516 doi "https://doi.org/10.1080/0269905031000088658" @default.
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