FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070291568> ?p ?o ?g. }

• W2070291568 endingPage "987" @default.
• W2070291568 startingPage "980" @default.
• W2070291568 abstract "Peroxisome proliferator-activated receptor γ (PPARγ) is a unique target for insulin sensitizer agents. These drugs have been used for the clinical treatment of type 2 diabetes for almost twenty years. However, serious safety issues are associated with the PPARγ agonist thiazolidinediones (TZDs). Selective PPARγ modulators (SPPARMs) which retain insulin sensitization without TZDs-like side effects are emerging as a promising new generation of insulin sensitizers. C333H is a novel structure compound synthesized by our laboratory. In diabetic rodent models, C333H has insulin-sensitizing and glucose-lowering activity comparable to that of TZDs, and causes no significant increase in body weight or adipose tissue weight in db/db mice. In diabetic db/db mice, C333H elevated circulating high molecular weight adiponectin isoforms, decreased PPARγ 273 serine phosphorylation in brown adipose tissue and selectively modulated the expression of a subset of PPARγ target genes in adipose tissue. In vitro, C333H weakly recruited coactivator and weakly dissociated corepressor activity. These findings suggest that C333H has similar properties to SPPARMs and may be a potential therapeutic agent for the treatment of type 2 diabetes." @default.
• W2070291568 created "2016-06-24" @default.
• W2070291568 creator A5023492006 @default.
• W2070291568 creator A5032804467 @default.
• W2070291568 creator A5036073443 @default.
• W2070291568 creator A5054418515 @default.
• W2070291568 creator A5063616750 @default.
• W2070291568 creator A5075286263 @default.
• W2070291568 creator A5077700681 @default.
• W2070291568 creator A5089255910 @default.
• W2070291568 date "2013-01-01" @default.
• W2070291568 modified "2023-09-28" @default.
• W2070291568 title "C333H Ameliorated Insulin Resistance through Selectively Modulating Peroxisome Proliferator-Activated Receptor γ in Brown Adipose Tissue of db/db Mice" @default.
• W2070291568 cites W1485161311 @default.
• W2070291568 cites W1983718158 @default.
• W2070291568 cites W1994128751 @default.
• W2070291568 cites W2033204507 @default.
• W2070291568 cites W2064326876 @default.
• W2070291568 cites W2087613795 @default.
• W2070291568 cites W2112936536 @default.
• W2070291568 cites W2135009079 @default.
• W2070291568 cites W2151807579 @default.
• W2070291568 cites W2161174158 @default.
• W2070291568 cites W2168761911 @default.
• W2070291568 cites W4240449862 @default.
• W2070291568 doi "https://doi.org/10.1248/bpb.b13-00008" @default.
• W2070291568 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23563593" @default.
• W2070291568 hasPublicationYear "2013" @default.
• W2070291568 type Work @default.
• W2070291568 sameAs 2070291568 @default.
• W2070291568 citedByCount "7" @default.
• W2070291568 countsByYear W20702915682015 @default.
• W2070291568 countsByYear W20702915682017 @default.
• W2070291568 countsByYear W20702915682018 @default.
• W2070291568 crossrefType "journal-article" @default.
• W2070291568 hasAuthorship W2070291568A5023492006 @default.
• W2070291568 hasAuthorship W2070291568A5032804467 @default.
• W2070291568 hasAuthorship W2070291568A5036073443 @default.
• W2070291568 hasAuthorship W2070291568A5054418515 @default.
• W2070291568 hasAuthorship W2070291568A5063616750 @default.
• W2070291568 hasAuthorship W2070291568A5075286263 @default.
• W2070291568 hasAuthorship W2070291568A5077700681 @default.
• W2070291568 hasAuthorship W2070291568A5089255910 @default.
• W2070291568 hasBestOaLocation W20702915681 @default.
• W2070291568 hasConcept C104317684 @default.
• W2070291568 hasConcept C126322002 @default.
• W2070291568 hasConcept C134018914 @default.
• W2070291568 hasConcept C151955695 @default.
• W2070291568 hasConcept C170493617 @default.
• W2070291568 hasConcept C171089720 @default.
• W2070291568 hasConcept C185592680 @default.
• W2070291568 hasConcept C187345961 @default.
• W2070291568 hasConcept C2776782570 @default.
• W2070291568 hasConcept C2777180221 @default.
• W2070291568 hasConcept C2777391703 @default.
• W2070291568 hasConcept C2778384471 @default.
• W2070291568 hasConcept C2778938600 @default.
• W2070291568 hasConcept C2779306644 @default.
• W2070291568 hasConcept C2780642333 @default.
• W2070291568 hasConcept C55493867 @default.
• W2070291568 hasConcept C555293320 @default.
• W2070291568 hasConcept C71924100 @default.
• W2070291568 hasConcept C77445288 @default.
• W2070291568 hasConcept C86339819 @default.
• W2070291568 hasConcept C86803240 @default.
• W2070291568 hasConceptScore W2070291568C104317684 @default.
• W2070291568 hasConceptScore W2070291568C126322002 @default.
• W2070291568 hasConceptScore W2070291568C134018914 @default.
• W2070291568 hasConceptScore W2070291568C151955695 @default.
• W2070291568 hasConceptScore W2070291568C170493617 @default.
• W2070291568 hasConceptScore W2070291568C171089720 @default.
• W2070291568 hasConceptScore W2070291568C185592680 @default.
• W2070291568 hasConceptScore W2070291568C187345961 @default.
• W2070291568 hasConceptScore W2070291568C2776782570 @default.
• W2070291568 hasConceptScore W2070291568C2777180221 @default.
• W2070291568 hasConceptScore W2070291568C2777391703 @default.
• W2070291568 hasConceptScore W2070291568C2778384471 @default.
• W2070291568 hasConceptScore W2070291568C2778938600 @default.
• W2070291568 hasConceptScore W2070291568C2779306644 @default.
• W2070291568 hasConceptScore W2070291568C2780642333 @default.
• W2070291568 hasConceptScore W2070291568C55493867 @default.
• W2070291568 hasConceptScore W2070291568C555293320 @default.
• W2070291568 hasConceptScore W2070291568C71924100 @default.
• W2070291568 hasConceptScore W2070291568C77445288 @default.
• W2070291568 hasConceptScore W2070291568C86339819 @default.
• W2070291568 hasConceptScore W2070291568C86803240 @default.
• W2070291568 hasIssue "6" @default.
• W2070291568 hasLocation W20702915681 @default.
• W2070291568 hasLocation W20702915682 @default.
• W2070291568 hasOpenAccess W2070291568 @default.
• W2070291568 hasPrimaryLocation W20702915681 @default.
• W2070291568 hasRelatedWork W1957106181 @default.
• W2070291568 hasRelatedWork W1971084642 @default.
• W2070291568 hasRelatedWork W2011657070 @default.
• W2070291568 hasRelatedWork W2061988825 @default.
• W2070291568 hasRelatedWork W2066062695 @default.
• W2070291568 hasRelatedWork W2070291568 @default.
• W2070291568 hasRelatedWork W2076371608 @default.

• next