Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070291679> ?p ?o ?g. }
- W2070291679 endingPage "1196" @default.
- W2070291679 startingPage "1188" @default.
- W2070291679 abstract "The interaction between macrophages and oxidatively modified low density lipoprotein (Ox-LDL) appears to play a central role in the development of atherosclerosis, not only through foam cell formation but also via the induction of numerous cytokines and growth factors. The current study demonstrated that Ox-LDL upregulated vascular endothelial growth factor (VEGF) mRNA expression in RAW 264 cells, a monocytic cell line, in a time- and concentration-dependent manner and that Ox-LDL stimulated VEGF protein secretion from the cells. Lysophosphatidylcholine, a component of Ox-LDL, also enhanced VEGF mRNA expression in RAW 264 cells and VEGF secretion from RAW 264 cells, with a maximal effect at a concentration of 10 micromol/L lysophosphatidylcholine. Immunohistochemical studies showed that human early atherosclerotic lesions exhibited intense VEGF immunoreactivity in subendothelial macrophage-rich regions of the thickened intima. In atherosclerotic plaques, VEGF staining was also observed in foam cell-rich regions adjacent to the lipid core or the neovascularized basal regions of plaque consisting predominantly of smooth muscle cells. High-power-field observation revealed that VEGF was localized in the extracellular space as well as at the macrophage cell surface. These observations suggest the possible involvement of Ox-LDL in the development of human atherosclerosis through VEGF induction in macrophages." @default.
- W2070291679 created "2016-06-24" @default.
- W2070291679 creator A5006648466 @default.
- W2070291679 creator A5010916565 @default.
- W2070291679 creator A5029516778 @default.
- W2070291679 creator A5035314420 @default.
- W2070291679 creator A5040641756 @default.
- W2070291679 creator A5049212130 @default.
- W2070291679 creator A5049254565 @default.
- W2070291679 creator A5071258630 @default.
- W2070291679 creator A5088408029 @default.
- W2070291679 date "1998-07-01" @default.
- W2070291679 modified "2023-10-12" @default.
- W2070291679 title "Induction of Macrophage VEGF in Response to Oxidized LDL and VEGF Accumulation in Human Atherosclerotic Lesions" @default.
- W2070291679 cites W1970357567 @default.
- W2070291679 cites W1971123289 @default.
- W2070291679 cites W1978470067 @default.
- W2070291679 cites W1983304194 @default.
- W2070291679 cites W1983763042 @default.
- W2070291679 cites W1991958278 @default.
- W2070291679 cites W1999223106 @default.
- W2070291679 cites W2004789344 @default.
- W2070291679 cites W2015344488 @default.
- W2070291679 cites W2029314163 @default.
- W2070291679 cites W2030720809 @default.
- W2070291679 cites W2036852690 @default.
- W2070291679 cites W2040579726 @default.
- W2070291679 cites W2042719333 @default.
- W2070291679 cites W2043863730 @default.
- W2070291679 cites W2045147217 @default.
- W2070291679 cites W2047408781 @default.
- W2070291679 cites W2054390123 @default.
- W2070291679 cites W2055111376 @default.
- W2070291679 cites W2056146626 @default.
- W2070291679 cites W2056374467 @default.
- W2070291679 cites W2057190622 @default.
- W2070291679 cites W2057576736 @default.
- W2070291679 cites W2057918209 @default.
- W2070291679 cites W2058587734 @default.
- W2070291679 cites W2070951814 @default.
- W2070291679 cites W2083259778 @default.
- W2070291679 cites W2099992849 @default.
- W2070291679 cites W2104573407 @default.
- W2070291679 cites W2105255713 @default.
- W2070291679 cites W2108145145 @default.
- W2070291679 cites W2111370069 @default.
- W2070291679 cites W2114098415 @default.
- W2070291679 cites W2120652037 @default.
- W2070291679 cites W2121594719 @default.
- W2070291679 cites W2137570167 @default.
- W2070291679 cites W2418871452 @default.
- W2070291679 cites W4241959557 @default.
- W2070291679 doi "https://doi.org/10.1161/01.atv.18.7.1188" @default.
- W2070291679 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9672081" @default.
- W2070291679 hasPublicationYear "1998" @default.
- W2070291679 type Work @default.
- W2070291679 sameAs 2070291679 @default.
- W2070291679 citedByCount "134" @default.
- W2070291679 countsByYear W20702916792012 @default.
- W2070291679 countsByYear W20702916792013 @default.
- W2070291679 countsByYear W20702916792014 @default.
- W2070291679 countsByYear W20702916792015 @default.
- W2070291679 countsByYear W20702916792016 @default.
- W2070291679 countsByYear W20702916792017 @default.
- W2070291679 countsByYear W20702916792018 @default.
- W2070291679 countsByYear W20702916792019 @default.
- W2070291679 countsByYear W20702916792020 @default.
- W2070291679 countsByYear W20702916792021 @default.
- W2070291679 countsByYear W20702916792022 @default.
- W2070291679 countsByYear W20702916792023 @default.
- W2070291679 crossrefType "journal-article" @default.
- W2070291679 hasAuthorship W2070291679A5006648466 @default.
- W2070291679 hasAuthorship W2070291679A5010916565 @default.
- W2070291679 hasAuthorship W2070291679A5029516778 @default.
- W2070291679 hasAuthorship W2070291679A5035314420 @default.
- W2070291679 hasAuthorship W2070291679A5040641756 @default.
- W2070291679 hasAuthorship W2070291679A5049212130 @default.
- W2070291679 hasAuthorship W2070291679A5049254565 @default.
- W2070291679 hasAuthorship W2070291679A5071258630 @default.
- W2070291679 hasAuthorship W2070291679A5088408029 @default.
- W2070291679 hasBestOaLocation W20702916791 @default.
- W2070291679 hasConcept C167734588 @default.
- W2070291679 hasConcept C185592680 @default.
- W2070291679 hasConcept C202751555 @default.
- W2070291679 hasConcept C2776330855 @default.
- W2070291679 hasConcept C2777025900 @default.
- W2070291679 hasConcept C2777895019 @default.
- W2070291679 hasConcept C2778596009 @default.
- W2070291679 hasConcept C2778918659 @default.
- W2070291679 hasConcept C2779244956 @default.
- W2070291679 hasConcept C41625074 @default.
- W2070291679 hasConcept C49039625 @default.
- W2070291679 hasConcept C502942594 @default.
- W2070291679 hasConcept C54355233 @default.
- W2070291679 hasConcept C55493867 @default.
- W2070291679 hasConcept C81885089 @default.
- W2070291679 hasConcept C86803240 @default.
- W2070291679 hasConcept C95444343 @default.