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- W2070291758 abstract "Adult male Sprague-Dawley rats were injected with pure honey bee venom and the serum corticosterone levels determined fluorometrically 1, 4, 8, and 24 hr after a single venom injection. Other rats received venom injections twice a week for a period of eight weeks during which serum corticosterone levels were determined as well as after a 4-week recovery period. In the acute study significant elevations in serum corticosterone levels occurred for periods up to 8 hr in those animals receiving the highest venom dose. The other experimental groups exhibited significantly elevated levels for periods up to 1 hr. The corticosterone levels of the injected groups were not significantly different from that of the controls 24 hr following injection. Large amounts of honey bee venom injected chronically were required to produce increases in adrenal gland corticosterone production. In vivo findings were confirmed by incubating the adrenal glands of the experimental animals in Krebs-Ringer bicarbonate buffer and fluorometrically determining the in vitro corticosterone production. Possible mechanisms of action of the venom are discussed." @default.
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- W2070291758 date "1972-01-01" @default.
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- W2070291758 title "The effect of the venom of the honey bee, Apis mellifera L., on the adrenocortical response of the adult male rat" @default.
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- W2070291758 doi "https://doi.org/10.1016/0041-0101(72)90090-6" @default.
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