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• W2070291783 abstract "Human thioredoxin reductase (TrxR) system is associated with cancer cell growth and anti-apoptosis process. Effects of 1, 2-[bis (1,2-Benzisoselenazolone-3 (2H) -ketone)]ethane (BBSKE), a novel TrxR inhibitor, were investigated on A549, HeLa, Bel-7402, BGC823 and KB cell lines. After treated with BBSKE, a good linear correlation coefficient (r>or=0.989) between TrxR activity and cell viability exists in each cell line together with cell growth/proliferation inhibition and apoptosis through Bcl-2/Bax and Caspase-3 pathways. These results suggest that there exists some relationship between TrxR inactivation and growth/proliferation inhibition or apoptosis in the investigated cell lines." @default.
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• W2070291783 date "2006-05-01" @default.
• W2070291783 modified "2023-10-18" @default.
• W2070291783 title "A thioredoxin reductase inhibitor induces growth inhibition and apoptosis in five cultured human carcinoma cell lines" @default.
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• W2070291783 doi "https://doi.org/10.1016/j.canlet.2005.05.010" @default.
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