Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070292087> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2070292087 endingPage "500" @default.
- W2070292087 startingPage "495" @default.
- W2070292087 abstract "The sparse-fur (spf) mutant mouse has an X-linked deficiency of hepatic ornithine transcarbamylase (OTC), and develops hyperammonemia immediately after weaning and maintains it throughout its life span. We have studied the effects of acetyl-L-carnitine (ALCAR) on the hepatic mitochondrial proteins of the chronically hyperammonemic spf mice. Two different age groups of mice were studied, the weanlings (3 weeks) and the adult mice (8 weeks). Our results indicate that in the mitochondrial matrix, the untreated chronic hyperammonemia induced a significant increase in the quantity of 54.4-kDa protein in spf adult mice. After ALCAR treatment, in spf adult mice, the quantities of the 54.4-kDa, 63.8-kDa, and 129-kDa matrix proteins were significantly increased. In the mitochondrial inner membrane fraction of the spf weanling mice, a 53.5-kDa protein was significantly increased by ALCAR treatment. Our results show that: (a) chronic hyperammonemia has altered the mitochondrial matrix protein profile in spf mice, that (b) ALCAR has a modulating effect on various matrix and inner membrane proteins, and that (c) there was no effect of hyperammonemia or ALCAR treatment on the outer membrane proteins." @default.
- W2070292087 created "2016-06-24" @default.
- W2070292087 creator A5017496392 @default.
- W2070292087 creator A5051918977 @default.
- W2070292087 date "2001-01-01" @default.
- W2070292087 modified "2023-10-03" @default.
- W2070292087 title "Hepatic Mitochondrial Proteins in Congenitally Hyperammonemic spf Mice: Effect of Acetyl-L-carnitine" @default.
- W2070292087 cites W139165379 @default.
- W2070292087 cites W2477276163 @default.
- W2070292087 doi "https://doi.org/10.1271/bbb.65.495" @default.
- W2070292087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11330659" @default.
- W2070292087 hasPublicationYear "2001" @default.
- W2070292087 type Work @default.
- W2070292087 sameAs 2070292087 @default.
- W2070292087 citedByCount "1" @default.
- W2070292087 countsByYear W20702920872012 @default.
- W2070292087 crossrefType "journal-article" @default.
- W2070292087 hasAuthorship W2070292087A5017496392 @default.
- W2070292087 hasAuthorship W2070292087A5051918977 @default.
- W2070292087 hasBestOaLocation W20702920871 @default.
- W2070292087 hasConcept C11701378 @default.
- W2070292087 hasConcept C126322002 @default.
- W2070292087 hasConcept C134018914 @default.
- W2070292087 hasConcept C181199279 @default.
- W2070292087 hasConcept C185592680 @default.
- W2070292087 hasConcept C2777468819 @default.
- W2070292087 hasConcept C2778377652 @default.
- W2070292087 hasConcept C2778433245 @default.
- W2070292087 hasConcept C2778435403 @default.
- W2070292087 hasConcept C2780655333 @default.
- W2070292087 hasConcept C2781099255 @default.
- W2070292087 hasConcept C28859421 @default.
- W2070292087 hasConcept C2908967332 @default.
- W2070292087 hasConcept C515207424 @default.
- W2070292087 hasConcept C55493867 @default.
- W2070292087 hasConcept C71924100 @default.
- W2070292087 hasConcept C75385678 @default.
- W2070292087 hasConcept C77061444 @default.
- W2070292087 hasConcept C86803240 @default.
- W2070292087 hasConcept C98539663 @default.
- W2070292087 hasConceptScore W2070292087C11701378 @default.
- W2070292087 hasConceptScore W2070292087C126322002 @default.
- W2070292087 hasConceptScore W2070292087C134018914 @default.
- W2070292087 hasConceptScore W2070292087C181199279 @default.
- W2070292087 hasConceptScore W2070292087C185592680 @default.
- W2070292087 hasConceptScore W2070292087C2777468819 @default.
- W2070292087 hasConceptScore W2070292087C2778377652 @default.
- W2070292087 hasConceptScore W2070292087C2778433245 @default.
- W2070292087 hasConceptScore W2070292087C2778435403 @default.
- W2070292087 hasConceptScore W2070292087C2780655333 @default.
- W2070292087 hasConceptScore W2070292087C2781099255 @default.
- W2070292087 hasConceptScore W2070292087C28859421 @default.
- W2070292087 hasConceptScore W2070292087C2908967332 @default.
- W2070292087 hasConceptScore W2070292087C515207424 @default.
- W2070292087 hasConceptScore W2070292087C55493867 @default.
- W2070292087 hasConceptScore W2070292087C71924100 @default.
- W2070292087 hasConceptScore W2070292087C75385678 @default.
- W2070292087 hasConceptScore W2070292087C77061444 @default.
- W2070292087 hasConceptScore W2070292087C86803240 @default.
- W2070292087 hasConceptScore W2070292087C98539663 @default.
- W2070292087 hasIssue "3" @default.
- W2070292087 hasLocation W20702920871 @default.
- W2070292087 hasLocation W20702920872 @default.
- W2070292087 hasOpenAccess W2070292087 @default.
- W2070292087 hasPrimaryLocation W20702920871 @default.
- W2070292087 hasRelatedWork W1979483967 @default.
- W2070292087 hasRelatedWork W2070292087 @default.
- W2070292087 hasRelatedWork W2089433119 @default.
- W2070292087 hasRelatedWork W2095192135 @default.
- W2070292087 hasRelatedWork W2136747214 @default.
- W2070292087 hasRelatedWork W2405065039 @default.
- W2070292087 hasRelatedWork W2409497452 @default.
- W2070292087 hasRelatedWork W2991740946 @default.
- W2070292087 hasRelatedWork W3164855192 @default.
- W2070292087 hasRelatedWork W4313220671 @default.
- W2070292087 hasVolume "65" @default.
- W2070292087 isParatext "false" @default.
- W2070292087 isRetracted "false" @default.
- W2070292087 magId "2070292087" @default.
- W2070292087 workType "article" @default.