FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070292227> ?p ?o ?g. }

• W2070292227 endingPage "279" @default.
• W2070292227 startingPage "265" @default.
• W2070292227 abstract "Latencies of visually evoked potentials (VEPs) tend to be abnormally long in multiple sclerosis (MS). Similar VEP delays are seen in glaucoma. Such delays could result in part from reduced intensities of synaptic inputs at post-retinal synaptic relays, and defects of axoplasmic transport might be one cause for this. The effective rate of synaptic activation of a given postsynaptic neuron can be decreased either by reducing the arrival-rate of presynaptic action potentials (e.g., by complete or partial blockage of conduction in some presynaptic axons), or by reducing the quantity of neurotransmitter released per action potential (e.g., as a consequence of presynaptic neurotransmitter depletion). It is proposed that in both glaucoma and MS, delayed VEPs may result from either or both of these mechanisms. Firstly, loss and functional impairment of optic nerve axons occurs in each disorder. Secondly, in glaucoma the increased intraocular pressure tends to block the rapid anterograde axoplasmic transport (RAAT) which brings neurotransmitter supplies to the axon terminals. This could result in neurotransmitter depletion in the lateral geniculate relay, decreased synaptic effectiveness of remaining normally-conducting optic nerve axons, and thereby increased VEP latencies. RAAT is also blocked by demyelinated lesions that have been produced experimentally by injection of diphtheria toxin. If it is impaired by the demyelinated plaques of multiple sclerosis, then VEP slowing by a similar presynaptic depletion mechanism could ensue." @default.
• W2070292227 created "2016-06-24" @default.
• W2070292227 creator A5026720826 @default.
• W2070292227 date "1985-11-01" @default.
• W2070292227 modified "2023-09-26" @default.
• W2070292227 title "How might demyelinating disorders and glaucoma modify synaptic function?" @default.
• W2070292227 cites W110630830 @default.
• W2070292227 cites W129722816 @default.
• W2070292227 cites W1561165420 @default.
• W2070292227 cites W16048049 @default.
• W2070292227 cites W169616773 @default.
• W2070292227 cites W1940636684 @default.
• W2070292227 cites W1966167725 @default.
• W2070292227 cites W1969824248 @default.
• W2070292227 cites W1971908868 @default.
• W2070292227 cites W1974309147 @default.
• W2070292227 cites W1976316322 @default.
• W2070292227 cites W1996522518 @default.
• W2070292227 cites W2001373813 @default.
• W2070292227 cites W2001551561 @default.
• W2070292227 cites W2004243698 @default.
• W2070292227 cites W2004289448 @default.
• W2070292227 cites W2007137520 @default.
• W2070292227 cites W2011809254 @default.
• W2070292227 cites W2015074583 @default.
• W2070292227 cites W2020221416 @default.
• W2070292227 cites W2037362048 @default.
• W2070292227 cites W2040170366 @default.
• W2070292227 cites W2042056689 @default.
• W2070292227 cites W2045395788 @default.
• W2070292227 cites W2046496497 @default.
• W2070292227 cites W2047120531 @default.
• W2070292227 cites W2048962391 @default.
• W2070292227 cites W2050894508 @default.
• W2070292227 cites W2051415087 @default.
• W2070292227 cites W2052787559 @default.
• W2070292227 cites W2054966081 @default.
• W2070292227 cites W2057813959 @default.
• W2070292227 cites W2058630549 @default.
• W2070292227 cites W2061018962 @default.
• W2070292227 cites W2069550427 @default.
• W2070292227 cites W2069884293 @default.
• W2070292227 cites W2071458359 @default.
• W2070292227 cites W2072982183 @default.
• W2070292227 cites W2091469930 @default.
• W2070292227 cites W2092032514 @default.
• W2070292227 cites W2102669589 @default.
• W2070292227 cites W2106073437 @default.
• W2070292227 cites W2110416204 @default.
• W2070292227 cites W2124383883 @default.
• W2070292227 cites W2152369557 @default.
• W2070292227 cites W2161875345 @default.
• W2070292227 cites W2167424526 @default.
• W2070292227 cites W2168575540 @default.
• W2070292227 cites W2213031753 @default.
• W2070292227 cites W2330008429 @default.
• W2070292227 cites W2396189170 @default.
• W2070292227 cites W2412635652 @default.
• W2070292227 cites W2416655031 @default.
• W2070292227 cites W2468421412 @default.
• W2070292227 cites W36215302 @default.
• W2070292227 cites W46655631 @default.
• W2070292227 cites W60697477 @default.
• W2070292227 cites W79813936 @default.
• W2070292227 cites W83427670 @default.
• W2070292227 cites W85720013 @default.
• W2070292227 cites W946809730 @default.
• W2070292227 doi "https://doi.org/10.1016/0306-9877(85)90028-3" @default.
• W2070292227 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3853082" @default.
• W2070292227 hasPublicationYear "1985" @default.
• W2070292227 type Work @default.
• W2070292227 sameAs 2070292227 @default.
• W2070292227 citedByCount "1" @default.
• W2070292227 crossrefType "journal-article" @default.
• W2070292227 hasAuthorship W2070292227A5026720826 @default.
• W2070292227 hasConcept C169760540 @default.
• W2070292227 hasConcept C170493617 @default.
• W2070292227 hasConcept C185592680 @default.
• W2070292227 hasConcept C197341189 @default.
• W2070292227 hasConcept C2776219046 @default.
• W2070292227 hasConcept C2779530196 @default.
• W2070292227 hasConcept C2780837183 @default.
• W2070292227 hasConcept C529278444 @default.
• W2070292227 hasConcept C55493867 @default.
• W2070292227 hasConcept C70192387 @default.
• W2070292227 hasConcept C86803240 @default.
• W2070292227 hasConceptScore W2070292227C169760540 @default.
• W2070292227 hasConceptScore W2070292227C170493617 @default.
• W2070292227 hasConceptScore W2070292227C185592680 @default.
• W2070292227 hasConceptScore W2070292227C197341189 @default.
• W2070292227 hasConceptScore W2070292227C2776219046 @default.
• W2070292227 hasConceptScore W2070292227C2779530196 @default.
• W2070292227 hasConceptScore W2070292227C2780837183 @default.
• W2070292227 hasConceptScore W2070292227C529278444 @default.
• W2070292227 hasConceptScore W2070292227C55493867 @default.
• W2070292227 hasConceptScore W2070292227C70192387 @default.
• W2070292227 hasConceptScore W2070292227C86803240 @default.
• W2070292227 hasIssue "3" @default.

• next