Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070294405> ?p ?o ?g. }
- W2070294405 endingPage "20" @default.
- W2070294405 startingPage "1" @default.
- W2070294405 abstract "The zebrafish ( Danio rerio ) has recently become a common model in the fields of genetics, environmental science, toxicology, and especially drug screening. Zebrafish has emerged as a biomedically relevant model for in vivo high content drug screening and the simultaneous determination of multiple efficacy parameters, including behaviour, selectivity, and toxicity in the content of the whole organism. A zebrafish behavioural assay has been demonstrated as a novel, rapid, and high-throughput approach to the discovery of neuroactive, psychoactive, and memory-modulating compounds. Recent studies found a functional similarity of drug metabolism systems in zebrafish and mammals, providing a clue with why some compounds are active in zebrafish in vivo but not in vitro , as well as providing grounds for the rationales supporting the use of a zebrafish screen to identify prodrugs. Here, we discuss the advantages of the zebrafish model for evaluating drug metabolism and the mode of pharmacological action with the emerging omics approaches. Why this model is suitable for identifying lead compounds from natural products for therapy of disorders with multifactorial etiopathogenesis and imbalance of angiogenesis, such as Parkinson's disease, epilepsy, cardiotoxicity, cerebral hemorrhage, dyslipidemia, and hyperlipidemia, is addressed." @default.
- W2070294405 created "2016-06-24" @default.
- W2070294405 creator A5005527272 @default.
- W2070294405 creator A5010348183 @default.
- W2070294405 creator A5030062334 @default.
- W2070294405 creator A5033290515 @default.
- W2070294405 creator A5053168038 @default.
- W2070294405 creator A5053935265 @default.
- W2070294405 creator A5058188605 @default.
- W2070294405 creator A5066525634 @default.
- W2070294405 creator A5070019476 @default.
- W2070294405 date "2012-01-01" @default.
- W2070294405 modified "2023-10-17" @default.
- W2070294405 title "From Omics to Drug Metabolism and High Content Screen of Natural Product in Zebrafish: A New Model for Discovery of Neuroactive Compound" @default.
- W2070294405 cites W1489080036 @default.
- W2070294405 cites W1525160624 @default.
- W2070294405 cites W1562759933 @default.
- W2070294405 cites W1573363574 @default.
- W2070294405 cites W1590123136 @default.
- W2070294405 cites W1629697287 @default.
- W2070294405 cites W1675915187 @default.
- W2070294405 cites W1963593603 @default.
- W2070294405 cites W1964639766 @default.
- W2070294405 cites W1967693452 @default.
- W2070294405 cites W1967695541 @default.
- W2070294405 cites W1967900006 @default.
- W2070294405 cites W1968184310 @default.
- W2070294405 cites W1969985837 @default.
- W2070294405 cites W1970698118 @default.
- W2070294405 cites W1972101224 @default.
- W2070294405 cites W1973260112 @default.
- W2070294405 cites W1975411923 @default.
- W2070294405 cites W197638603 @default.
- W2070294405 cites W1978377628 @default.
- W2070294405 cites W1979457930 @default.
- W2070294405 cites W1979771830 @default.
- W2070294405 cites W1980604577 @default.
- W2070294405 cites W1981509058 @default.
- W2070294405 cites W1982033956 @default.
- W2070294405 cites W1982617925 @default.
- W2070294405 cites W1985022434 @default.
- W2070294405 cites W1985693917 @default.
- W2070294405 cites W1986311196 @default.
- W2070294405 cites W1989011678 @default.
- W2070294405 cites W1990061956 @default.
- W2070294405 cites W1990484548 @default.
- W2070294405 cites W1992746042 @default.
- W2070294405 cites W1994683039 @default.
- W2070294405 cites W1995469282 @default.
- W2070294405 cites W1996315798 @default.
- W2070294405 cites W1997023151 @default.
- W2070294405 cites W1997053062 @default.
- W2070294405 cites W2000288523 @default.
- W2070294405 cites W2000341627 @default.
- W2070294405 cites W2003393468 @default.
- W2070294405 cites W2004772935 @default.
- W2070294405 cites W2007026386 @default.
- W2070294405 cites W2007479108 @default.
- W2070294405 cites W2009476579 @default.
- W2070294405 cites W2009615168 @default.
- W2070294405 cites W2011813453 @default.
- W2070294405 cites W2012446252 @default.
- W2070294405 cites W2013027611 @default.
- W2070294405 cites W2014281284 @default.
- W2070294405 cites W2019019227 @default.
- W2070294405 cites W2019169880 @default.
- W2070294405 cites W2020656090 @default.
- W2070294405 cites W2022716009 @default.
- W2070294405 cites W2023123197 @default.
- W2070294405 cites W2024727214 @default.
- W2070294405 cites W2025173848 @default.
- W2070294405 cites W2026657707 @default.
- W2070294405 cites W2026716757 @default.
- W2070294405 cites W2031649732 @default.
- W2070294405 cites W2034246838 @default.
- W2070294405 cites W2034487271 @default.
- W2070294405 cites W2035114961 @default.
- W2070294405 cites W2035138652 @default.
- W2070294405 cites W2036303851 @default.
- W2070294405 cites W2038690111 @default.
- W2070294405 cites W2039437431 @default.
- W2070294405 cites W2040357907 @default.
- W2070294405 cites W2042175324 @default.
- W2070294405 cites W2042667266 @default.
- W2070294405 cites W2043425870 @default.
- W2070294405 cites W2044192395 @default.
- W2070294405 cites W2044627978 @default.
- W2070294405 cites W2046275738 @default.
- W2070294405 cites W2046548944 @default.
- W2070294405 cites W2046584597 @default.
- W2070294405 cites W2046644529 @default.
- W2070294405 cites W2046759540 @default.
- W2070294405 cites W2048890665 @default.
- W2070294405 cites W2049870433 @default.
- W2070294405 cites W2050677837 @default.
- W2070294405 cites W2052849392 @default.
- W2070294405 cites W2053229559 @default.
- W2070294405 cites W2054058695 @default.