FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070294445> ?p ?o ?g. }

• W2070294445 endingPage "493" @default.
• W2070294445 startingPage "493" @default.
• W2070294445 abstract "Background: Nitric Oxide (NO) released by pulmonary vascular endothelium is a potent vasodilator related to increased cGMP content. Hydrolysis of cGMP is achieved predominantly by cGMP–specific phosphodiesterases (PDEs). Sildenafil (SILD) is a selective phosphodiesterase–5 (PDE–5) inhibitor. The purpose of the study was to assess the effects of sildenafil on pulmonary vascular circulation during the perinatal period. Methods: 12 pregnant ewes were operated on between 128 and 130 days gestation (term = 145 d). Catheters were placed into the ascending aorta, superior vena cava, main pulmonary artery and left atrium. An ultrasonic flow transducer was placed around left pulmonary artery (LPA). An inflatable vascular occluder was placed around ductus arteriosus (DA). Acute DA compression increases pulmonary artery pressure (PAP) causing an increase in pulmonary blood flow (Q) and a progressive decline in pulmonary vascular resistance (PVR). Fetal lambs were divided in two groups: 1) a SILD group infused continuously with SILD at a rate of 24 mg/day (n=6) and; 2/ control group (CONT) infused with saline (n=6). After 24 hrs of infusion, we compared the hemodynamic response of LPA to: 1) increased fetal PaO2 (maternal O2 inhalation for 30 min), and; 2) increase in vascular shear-stress (flow-induced pulmonary vasodilatation related to DA compression). Results: Mean PAP, Q and PVR were similar in both groups before and after 24 h of SILD or saline infusion. Despite similar baseline values, PVR during maternal O2 inhalation was lower in SILD than in CONT group (0.23±0.01 vs 0.27±0.01 mmHg/ml.min−1 respectively) (p<0.01). Furthermore, drop in PVR during acute DA compression was greater in the SILD group (from 0.54±0.03 to 0.26±0.02 mmHg/ml.min−1) than in the CONT group (from 0.55±0.04 to 0.39±0.02 mmHg/ml.min−1) (p<0.01). Conclusion: Although no difference was found in the basal pulmonary vascular tone, sildenafil increases pulmonary vascular reactivity in the ovine fetus. These data suggest that PDE–5 is involved in the regulation of pulmonary vascular reactivity during the perinatal period. We further speculate that specific inhibitor of PDE–5 may potentiate birth related pulmonary vasodilator stimuli and could improve conditions associated with failure to circulatory adaptation at birth." @default.
• W2070294445 created "2016-06-24" @default.
• W2070294445 creator A5006300470 @default.
• W2070294445 creator A5008141836 @default.
• W2070294445 creator A5011829843 @default.
• W2070294445 creator A5017892381 @default.
• W2070294445 creator A5018909684 @default.
• W2070294445 creator A5047865709 @default.
• W2070294445 creator A5047998715 @default.
• W2070294445 creator A5070983113 @default.
• W2070294445 date "2004-09-01" @default.
• W2070294445 modified "2023-09-26" @default.
• W2070294445 title "173 Effects of Phosphodiesterase 5 Inhibitor on Pulmonary Vascular Reactivity in The Fetal Lamb" @default.
• W2070294445 doi "https://doi.org/10.1203/00006450-200409000-00196" @default.
• W2070294445 hasPublicationYear "2004" @default.
• W2070294445 type Work @default.
• W2070294445 sameAs 2070294445 @default.
• W2070294445 citedByCount "0" @default.
• W2070294445 crossrefType "journal-article" @default.
• W2070294445 hasAuthorship W2070294445A5006300470 @default.
• W2070294445 hasAuthorship W2070294445A5008141836 @default.
• W2070294445 hasAuthorship W2070294445A5011829843 @default.
• W2070294445 hasAuthorship W2070294445A5017892381 @default.
• W2070294445 hasAuthorship W2070294445A5018909684 @default.
• W2070294445 hasAuthorship W2070294445A5047865709 @default.
• W2070294445 hasAuthorship W2070294445A5047998715 @default.
• W2070294445 hasAuthorship W2070294445A5070983113 @default.
• W2070294445 hasBestOaLocation W20702944451 @default.
• W2070294445 hasConcept C120770815 @default.
• W2070294445 hasConcept C126322002 @default.
• W2070294445 hasConcept C164705383 @default.
• W2070294445 hasConcept C178853913 @default.
• W2070294445 hasConcept C2776768464 @default.
• W2070294445 hasConcept C2780930700 @default.
• W2070294445 hasConcept C2780940725 @default.
• W2070294445 hasConcept C2781236024 @default.
• W2070294445 hasConcept C2910216633 @default.
• W2070294445 hasConcept C42219234 @default.
• W2070294445 hasConcept C519581460 @default.
• W2070294445 hasConcept C58245268 @default.
• W2070294445 hasConcept C71924100 @default.
• W2070294445 hasConcept C74534348 @default.
• W2070294445 hasConceptScore W2070294445C120770815 @default.
• W2070294445 hasConceptScore W2070294445C126322002 @default.
• W2070294445 hasConceptScore W2070294445C164705383 @default.
• W2070294445 hasConceptScore W2070294445C178853913 @default.
• W2070294445 hasConceptScore W2070294445C2776768464 @default.
• W2070294445 hasConceptScore W2070294445C2780930700 @default.
• W2070294445 hasConceptScore W2070294445C2780940725 @default.
• W2070294445 hasConceptScore W2070294445C2781236024 @default.
• W2070294445 hasConceptScore W2070294445C2910216633 @default.
• W2070294445 hasConceptScore W2070294445C42219234 @default.
• W2070294445 hasConceptScore W2070294445C519581460 @default.
• W2070294445 hasConceptScore W2070294445C58245268 @default.
• W2070294445 hasConceptScore W2070294445C71924100 @default.
• W2070294445 hasConceptScore W2070294445C74534348 @default.
• W2070294445 hasIssue "3" @default.
• W2070294445 hasLocation W20702944451 @default.
• W2070294445 hasOpenAccess W2070294445 @default.
• W2070294445 hasPrimaryLocation W20702944451 @default.
• W2070294445 hasRelatedWork W1973664081 @default.
• W2070294445 hasRelatedWork W1986615974 @default.
• W2070294445 hasRelatedWork W2008435861 @default.
• W2070294445 hasRelatedWork W2032126076 @default.
• W2070294445 hasRelatedWork W2067313134 @default.
• W2070294445 hasRelatedWork W2070294445 @default.
• W2070294445 hasRelatedWork W2085337162 @default.
• W2070294445 hasRelatedWork W2118817224 @default.
• W2070294445 hasRelatedWork W2478461153 @default.
• W2070294445 hasRelatedWork W1823043574 @default.
• W2070294445 hasVolume "56" @default.
• W2070294445 isParatext "false" @default.
• W2070294445 isRetracted "false" @default.
• W2070294445 magId "2070294445" @default.
• W2070294445 workType "article" @default.