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- W2070294742 abstract "The ribosome is the target of a large number of antibiotics. Here, we report a 3.4-Å-resolution crystal structure of bactobolin A bound to 70S ribosome-tRNA complex. The antibiotic binds at a previously unseen site in the 50S subunit and displaces tRNA bound at the P-site. It thus likely has a similar mechanism of action as blasticidin S despite binding to a different site. The structure also rationalizes previously identified resistance mutations." @default.
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- W2070294742 date "2015-02-01" @default.
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- W2070294742 title "Bactobolin A Binds to a Site on the 70S Ribosome Distinct from Previously Seen Antibiotics" @default.
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- W2070294742 doi "https://doi.org/10.1016/j.jmb.2014.12.018" @default.
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