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- W2070294913 abstract "A liquid chromatography–tandem mass spectrometry method was developed for the identification of metabolites of trantinterol, a novel β2-adrenoceptor agonist, in beagle dog urine. The separation of metabolites was performed on a reversed-phase C8 column using 0.1% formic acid in water and methanol (70 : 30, v/v) as the mobile phase. The structural information and elemental information of metabolites were acquired by an electrospray ionization tandem mass spectrometer and a quadrupole time-of-flight mass spectrometer, respectively. A total of 13 metabolites were detected and characterized on the basis of their tandem MS/MS fragmentation patterns. The accurate masses of nine metabolites were determined and two metabolites were further confirmed by comparing with reference standards. The metabolic pathways of trantinterol in beagle dog are proposed. Copyright © 2009 John Wiley & Sons, Ltd." @default.
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- W2070294913 date "2009-01-01" @default.
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- W2070294913 title "Liquid chromatography-mass spectrometry for analysis of a novel β<sub>2</sub>-adrenoceptor agonist trantinterol and its metabolites in beagle dog urine" @default.
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- W2070294913 doi "https://doi.org/10.1002/bmc.1284" @default.
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