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• W2070296847 endingPage "42085" @default.
• W2070296847 startingPage "42075" @default.
• W2070296847 abstract "A theme emerging during the past few years is that members of the small leucine-rich proteoglycan gene family affect cell growth by interacting with multiple receptor tyrosine kinases (RTKs), mostly by a physical down-regulation of the receptors, thereby depriving tumor cells of pro-survival signals. Decorin binds and down-regulates several RTKs, including Met, the receptor for hepatocyte growth factor. Here we demonstrate that decorin blocks several biological activities mediated by the Met signaling axis, including cell scatter, evasion, and migration. These effects were mediated by a profound down-regulation of noncanonical β-catenin levels. In addition, Myc, a downstream target of β-catenin, was markedly down-regulated by decorin, whereas phosphorylation of Myc at threonine 58 was markedly induced. The latter is known to destabilize Myc and target it for proteasomal degradation. We also discovered that systemic delivery of decorin using three distinct tumor xenograft models caused down-regulation of Met and a concurrent suppression of β-catenin and Myc levels. We found that decorin protein core labeled with the near infrared dye IR800 specifically targeted the tumor cells expressing Met. Even 68-h post-injection, decorin was found to reside within the tumor xenografts with little or no binding to other tissues. Collectively, our results indicate a role for a secreted proteoglycan in suppressing the expression of key oncogenic factors required for tumor progression. A theme emerging during the past few years is that members of the small leucine-rich proteoglycan gene family affect cell growth by interacting with multiple receptor tyrosine kinases (RTKs), mostly by a physical down-regulation of the receptors, thereby depriving tumor cells of pro-survival signals. Decorin binds and down-regulates several RTKs, including Met, the receptor for hepatocyte growth factor. Here we demonstrate that decorin blocks several biological activities mediated by the Met signaling axis, including cell scatter, evasion, and migration. These effects were mediated by a profound down-regulation of noncanonical β-catenin levels. In addition, Myc, a downstream target of β-catenin, was markedly down-regulated by decorin, whereas phosphorylation of Myc at threonine 58 was markedly induced. The latter is known to destabilize Myc and target it for proteasomal degradation. We also discovered that systemic delivery of decorin using three distinct tumor xenograft models caused down-regulation of Met and a concurrent suppression of β-catenin and Myc levels. We found that decorin protein core labeled with the near infrared dye IR800 specifically targeted the tumor cells expressing Met. Even 68-h post-injection, decorin was found to reside within the tumor xenografts with little or no binding to other tissues. Collectively, our results indicate a role for a secreted proteoglycan in suppressing the expression of key oncogenic factors required for tumor progression." @default.
• W2070296847 created "2016-06-24" @default.
• W2070296847 creator A5006568068 @default.
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• W2070296847 creator A5038861339 @default.
• W2070296847 creator A5051174751 @default.
• W2070296847 creator A5082220471 @default.
• W2070296847 date "2010-12-01" @default.
• W2070296847 modified "2023-10-15" @default.
• W2070296847 title "Decorin Antagonizes Met Receptor Activity and Down-regulates β-Catenin and Myc Levels" @default.
• W2070296847 cites W1497186327 @default.
• W2070296847 cites W1506084650 @default.
• W2070296847 cites W1521898800 @default.
• W2070296847 cites W1544527238 @default.
• W2070296847 cites W1594164755 @default.
• W2070296847 cites W1597864831 @default.
• W2070296847 cites W1598189106 @default.
• W2070296847 cites W1964742508 @default.
• W2070296847 cites W1965517168 @default.
• W2070296847 cites W1966803171 @default.
• W2070296847 cites W1967835781 @default.
• W2070296847 cites W1969117282 @default.
• W2070296847 cites W1970237759 @default.
• W2070296847 cites W1970395087 @default.
• W2070296847 cites W1973876063 @default.
• W2070296847 cites W1974955986 @default.
• W2070296847 cites W1976298275 @default.
• W2070296847 cites W1977290507 @default.
• W2070296847 cites W1979495400 @default.
• W2070296847 cites W1979534544 @default.
• W2070296847 cites W1980534733 @default.
• W2070296847 cites W1980583475 @default.
• W2070296847 cites W1982874165 @default.
• W2070296847 cites W1984155123 @default.
• W2070296847 cites W1987539001 @default.
• W2070296847 cites W1989460846 @default.
• W2070296847 cites W1990320777 @default.
• W2070296847 cites W1993507992 @default.
• W2070296847 cites W1996332681 @default.
• W2070296847 cites W1997216820 @default.
• W2070296847 cites W1998971866 @default.
• W2070296847 cites W2002509647 @default.
• W2070296847 cites W2004897012 @default.
• W2070296847 cites W2008557163 @default.
• W2070296847 cites W2009219948 @default.
• W2070296847 cites W2009275473 @default.
• W2070296847 cites W2010501457 @default.
• W2070296847 cites W2016005410 @default.
• W2070296847 cites W2016146051 @default.
• W2070296847 cites W2020654012 @default.
• W2070296847 cites W2021050206 @default.
• W2070296847 cites W2023104790 @default.
• W2070296847 cites W2023713176 @default.
• W2070296847 cites W2035247707 @default.
• W2070296847 cites W2037109650 @default.
• W2070296847 cites W2037144867 @default.
• W2070296847 cites W2041650071 @default.
• W2070296847 cites W2045343723 @default.
• W2070296847 cites W2046024621 @default.
• W2070296847 cites W2046405795 @default.
• W2070296847 cites W2047578760 @default.
• W2070296847 cites W2051025473 @default.
• W2070296847 cites W2052801322 @default.
• W2070296847 cites W2055649502 @default.
• W2070296847 cites W2058106363 @default.
• W2070296847 cites W2058390366 @default.
• W2070296847 cites W2059581447 @default.
• W2070296847 cites W2062119438 @default.
• W2070296847 cites W2062348957 @default.
• W2070296847 cites W2068277926 @default.
• W2070296847 cites W2068963825 @default.
• W2070296847 cites W2070013317 @default.
• W2070296847 cites W2071413309 @default.
• W2070296847 cites W2071572077 @default.
• W2070296847 cites W2071812783 @default.
• W2070296847 cites W2072715633 @default.
• W2070296847 cites W2077038948 @default.
• W2070296847 cites W2077684583 @default.
• W2070296847 cites W2082315732 @default.
• W2070296847 cites W2083106832 @default.
• W2070296847 cites W2083515846 @default.
• W2070296847 cites W2088193529 @default.
• W2070296847 cites W2090603283 @default.
• W2070296847 cites W2091023302 @default.
• W2070296847 cites W2093453499 @default.
• W2070296847 cites W2099857141 @default.
• W2070296847 cites W2104669784 @default.
• W2070296847 cites W2106119346 @default.
• W2070296847 cites W2106704887 @default.
• W2070296847 cites W2107648723 @default.
• W2070296847 cites W2120347833 @default.
• W2070296847 cites W2121555787 @default.
• W2070296847 cites W2129656993 @default.
• W2070296847 cites W2130030207 @default.
• W2070296847 cites W2131687641 @default.
• W2070296847 cites W2136390065 @default.
• W2070296847 cites W2138366746 @default.

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