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• W2070299467 abstract "In order to visualize neuroanatomical alterations in specific brain regions, light microscopy autoradiography was carried out on neonatal brain sections from controls and neonates chronically treated with morphine. In the case of brains exposed to morphine from postnatal day (PD) 1–4, μ receptor density on PD 5 was non-existent in the patches of the striatum. There were also decreases in μ opiate receptor density in the surrounding matrix area, and in the nucleus accumbens and amygdala. Longer durations of morphine treatment (PD 1–8) did not show these alterations in μ opiate receptor density. These data demonstrate the unique plasticity seen in the immature opioid system. It is suggested that the differences observed in neonatal vs adult central nervous system may be due to interactions with and the differential development of the G-protein/cyclic adenosine 3′,5′-monophosphate (cAMP) system." @default.
• W2070299467 created "2016-06-24" @default.
• W2070299467 creator A5056638695 @default.
• W2070299467 date "1991-12-01" @default.
• W2070299467 modified "2023-10-16" @default.
• W2070299467 title "Visualization of μ opiate receptor downregulation following morphine treatment in neonatal rat brain" @default.
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• W2070299467 doi "https://doi.org/10.1016/0165-3806(91)90204-v" @default.
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