FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070299744> ?p ?o ?g. }

• W2070299744 endingPage "194" @default.
• W2070299744 startingPage "183" @default.
• W2070299744 abstract "The mechanism of toxicity for cytolytic lymphocytes of Leu-Leu-OMe and related dipeptide derivatives was examined. Selective inhibition of dipeptidyl peptidase I (DPPI), a lysosomal thiol protease highly enriched in cytotoxic lymphocytes, prevented all natural killer (NK) toxic effects of such agents. However, many DPPI substrates were found to possess no NK toxic properties. For some such agents, this lack of NK toxicity appeared to be related to the lack of uptake by lymphocytes. In this regard, Leu-Leu-OMe was found to be incorporated by lymphocytes and monocytes via a saturable facilitated transport mechanism with characteristics distinct from previously characterized mammalian dipeptide transport processes. This novel transport process was found to be specific for dipeptides composed of selective L-stereoisomer amino acids and enhanced by hydrophobic ester or amide additions to the COOH terminus of dipeptides. Maximal rates of Leu-Leu-OMe uptake by T8 and NK cell-enriched peripheral blood lymphocytes (PBL) were four- to sixfold higher than for T4-enriched PBL or PBL depleted of Leu-Leu-OMe-sensitive cytotoxic lymphocytes. All dipeptide amides or esters with NK toxic properties were found to act as competitive inhibitors of [3H]Leu-Leu-OMe uptake by PBL. However, some NK nontoxic DPPI substrates were found to be comparable with Leu-Leu-OMe in avidity for this transport process. Such agents were noted to possess one or more hydrophilic amino acid side chains and were found not to mediate red blood cell lysis when subjected to the acyl transferase activity of DPPI. Thus, uptake by a dipeptide-specific facilitated transport mechanism and conversion by DPPI to hydrophobic polymerization products with membranolytic properties were found to be common features of NK toxic dipeptide derivatives. The presence of a previously unreported dipeptide transport mechanism within blood leukocytes and the selective enrichment of the granule enzyme, DPPI, within cytotoxic effector cells of lymphoid or myeloid lineage appear to afford a unique mechanism for the targeting of immunotherapeutic reagents composed of simple dipeptide esters or amides." @default.
• W2070299744 created "2016-06-24" @default.
• W2070299744 creator A5033489913 @default.
• W2070299744 creator A5043874873 @default.
• W2070299744 date "1990-07-01" @default.
• W2070299744 modified "2023-10-08" @default.
• W2070299744 title "The action of leucyl-leucine methyl ester on cytotoxic lymphocytes requires uptake by a novel dipeptide-specific facilitated transport system and dipeptidyl peptidase I-mediated conversion to membranolytic products." @default.
• W2070299744 cites W1483824075 @default.
• W2070299744 cites W1484675846 @default.
• W2070299744 cites W1487399381 @default.
• W2070299744 cites W1494816908 @default.
• W2070299744 cites W1530246363 @default.
• W2070299744 cites W1553692071 @default.
• W2070299744 cites W1587621551 @default.
• W2070299744 cites W1608418211 @default.
• W2070299744 cites W1972255908 @default.
• W2070299744 cites W1974715394 @default.
• W2070299744 cites W1975549159 @default.
• W2070299744 cites W2004535295 @default.
• W2070299744 cites W2017419438 @default.
• W2070299744 cites W2035849683 @default.
• W2070299744 cites W2044007804 @default.
• W2070299744 cites W2046432457 @default.
• W2070299744 cites W2059586497 @default.
• W2070299744 cites W2070010734 @default.
• W2070299744 cites W2081024586 @default.
• W2070299744 cites W2081549017 @default.
• W2070299744 cites W2084542841 @default.
• W2070299744 cites W2099840056 @default.
• W2070299744 cites W2162493943 @default.
• W2070299744 cites W2166441000 @default.
• W2070299744 cites W2170834275 @default.
• W2070299744 cites W2410138781 @default.
• W2070299744 cites W4232534952 @default.
• W2070299744 doi "https://doi.org/10.1084/jem.172.1.183" @default.
• W2070299744 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2188150" @default.
• W2070299744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1972727" @default.
• W2070299744 hasPublicationYear "1990" @default.
• W2070299744 type Work @default.
• W2070299744 sameAs 2070299744 @default.
• W2070299744 citedByCount "52" @default.
• W2070299744 countsByYear W20702997442012 @default.
• W2070299744 countsByYear W20702997442013 @default.
• W2070299744 countsByYear W20702997442014 @default.
• W2070299744 countsByYear W20702997442015 @default.
• W2070299744 countsByYear W20702997442016 @default.
• W2070299744 countsByYear W20702997442017 @default.
• W2070299744 countsByYear W20702997442018 @default.
• W2070299744 countsByYear W20702997442019 @default.
• W2070299744 countsByYear W20702997442020 @default.
• W2070299744 countsByYear W20702997442021 @default.
• W2070299744 countsByYear W20702997442022 @default.
• W2070299744 countsByYear W20702997442023 @default.
• W2070299744 crossrefType "journal-article" @default.
• W2070299744 hasAuthorship W2070299744A5033489913 @default.
• W2070299744 hasAuthorship W2070299744A5043874873 @default.
• W2070299744 hasBestOaLocation W20702997441 @default.
• W2070299744 hasConcept C109316439 @default.
• W2070299744 hasConcept C145734084 @default.
• W2070299744 hasConcept C154317977 @default.
• W2070299744 hasConcept C181199279 @default.
• W2070299744 hasConcept C182220744 @default.
• W2070299744 hasConcept C185592680 @default.
• W2070299744 hasConcept C202751555 @default.
• W2070299744 hasConcept C2776580952 @default.
• W2070299744 hasConcept C2776714187 @default.
• W2070299744 hasConcept C2779138802 @default.
• W2070299744 hasConcept C2779281246 @default.
• W2070299744 hasConcept C2780985610 @default.
• W2070299744 hasConcept C515207424 @default.
• W2070299744 hasConcept C55493867 @default.
• W2070299744 hasConcept C73588182 @default.
• W2070299744 hasConcept C86803240 @default.
• W2070299744 hasConceptScore W2070299744C109316439 @default.
• W2070299744 hasConceptScore W2070299744C145734084 @default.
• W2070299744 hasConceptScore W2070299744C154317977 @default.
• W2070299744 hasConceptScore W2070299744C181199279 @default.
• W2070299744 hasConceptScore W2070299744C182220744 @default.
• W2070299744 hasConceptScore W2070299744C185592680 @default.
• W2070299744 hasConceptScore W2070299744C202751555 @default.
• W2070299744 hasConceptScore W2070299744C2776580952 @default.
• W2070299744 hasConceptScore W2070299744C2776714187 @default.
• W2070299744 hasConceptScore W2070299744C2779138802 @default.
• W2070299744 hasConceptScore W2070299744C2779281246 @default.
• W2070299744 hasConceptScore W2070299744C2780985610 @default.
• W2070299744 hasConceptScore W2070299744C515207424 @default.
• W2070299744 hasConceptScore W2070299744C55493867 @default.
• W2070299744 hasConceptScore W2070299744C73588182 @default.
• W2070299744 hasConceptScore W2070299744C86803240 @default.
• W2070299744 hasIssue "1" @default.
• W2070299744 hasLocation W20702997441 @default.
• W2070299744 hasLocation W20702997442 @default.
• W2070299744 hasLocation W20702997443 @default.
• W2070299744 hasLocation W20702997444 @default.
• W2070299744 hasOpenAccess W2070299744 @default.
• W2070299744 hasPrimaryLocation W20702997441 @default.
• W2070299744 hasRelatedWork W1675997988 @default.
• W2070299744 hasRelatedWork W1967771459 @default.

• next