FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070303911> ?p ?o ?g. }

• W2070303911 abstract "1. Effects of vasoactive substances were investigated in the canine isolated spinal branch of the intercostal artery (SBICA). 2. Addition of angiotensin II (AII), vasopressin, noradrenaline (NA), adrenaline, 5-hydroxytryptamine (5-HT), and dopamine each produced concentration-dependent contraction in the SBICA, whereas prostaglandin F2 alpha, histamine, and tyramine caused only slight contraction. The decreasing order of the potency of contractile agents was AII much greater than vasopressin = NA greater than 5-HT greater than adrenaline much greater than dopamine. 3. Although the pD2 value for phenylephrine (5.31 +/- 0.36) was smaller than that for NA (6.48 +/- 0.13), there was no significant difference in Emax value between these two agonists in the SBICA. On the other hand, xylazine produced only a slight contraction, the pD2 value being 3.59 +/- 0.08. Phentolamine (10(-8)-10(-6) M) and prazosin (10(-8)-10(-6) M) competitively inhibited the NA-induced contraction, while yohimbine (10(-8)-10(-6) M) did not. 4. Acetylcholine (ACh), sodium nitroprusside (SNP), ATP, ADP, and adenosine caused concentration-dependent relaxations in SBICA following contraction with NA. On the other hand, isoprenaline up to 10(-4) M did not produce any relaxation. The decreasing order of potency of the relaxant agents was ACh greater than SNP much greater than ATP = ADP = adenosine. 5. The ACh-induced relaxation was competitively inhibited by atropine and was abolished by mechanical removal of the endothelium. Aspirin (5 x 10(-5) M) did not affect the relaxant response to ACh, while oxyhaemoglobin (10(-5) M) and methylene blue (10(-5) M) produced significant attenuation. 6. These results suggest that NA produces contraction of the isolated canine SBICA which is mainly mediated via alpha 1-adrenoceptors and that ACh causes a relaxation of the SBICA due to release of endothelium-derived relaxing factor (EDRF) from the endothelial cells." @default.
• W2070303911 created "2016-06-24" @default.
• W2070303911 creator A5013836679 @default.
• W2070303911 creator A5029642493 @default.
• W2070303911 creator A5066674880 @default.
• W2070303911 date "1990-09-01" @default.
• W2070303911 modified "2023-09-27" @default.
• W2070303911 title "Contractile and relaxant responses of the canine isolated spinal artery to vasoactive substances" @default.
• W2070303911 cites W1967272841 @default.
• W2070303911 cites W1996738861 @default.
• W2070303911 cites W2005986999 @default.
• W2070303911 cites W2019274828 @default.
• W2070303911 cites W2020473277 @default.
• W2070303911 cites W2045461798 @default.
• W2070303911 cites W2048376122 @default.
• W2070303911 cites W2049072541 @default.
• W2070303911 cites W2055827946 @default.
• W2070303911 cites W2057971042 @default.
• W2070303911 cites W2062108542 @default.
• W2070303911 cites W2064391857 @default.
• W2070303911 cites W2065699718 @default.
• W2070303911 cites W2067386746 @default.
• W2070303911 cites W2067534650 @default.
• W2070303911 cites W2074578057 @default.
• W2070303911 cites W2091488220 @default.
• W2070303911 cites W2095391515 @default.
• W2070303911 cites W2119546846 @default.
• W2070303911 cites W2129175129 @default.
• W2070303911 cites W2138821274 @default.
• W2070303911 cites W2142975032 @default.
• W2070303911 cites W2155466144 @default.
• W2070303911 cites W2169182236 @default.
• W2070303911 cites W2264928076 @default.
• W2070303911 cites W2336223322 @default.
• W2070303911 cites W2398106814 @default.
• W2070303911 cites W2398289036 @default.
• W2070303911 cites W2404598939 @default.
• W2070303911 cites W2416624008 @default.
• W2070303911 cites W93489098 @default.
• W2070303911 cites W2150523710 @default.
• W2070303911 doi "https://doi.org/10.1111/j.1476-5381.1990.tb12113.x" @default.
• W2070303911 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1917648" @default.
• W2070303911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1980836" @default.
• W2070303911 hasPublicationYear "1990" @default.
• W2070303911 type Work @default.
• W2070303911 sameAs 2070303911 @default.
• W2070303911 citedByCount "7" @default.
• W2070303911 crossrefType "journal-article" @default.
• W2070303911 hasAuthorship W2070303911A5013836679 @default.
• W2070303911 hasAuthorship W2070303911A5029642493 @default.
• W2070303911 hasAuthorship W2070303911A5066674880 @default.
• W2070303911 hasBestOaLocation W20703039111 @default.
• W2070303911 hasConcept C126322002 @default.
• W2070303911 hasConcept C134018914 @default.
• W2070303911 hasConcept C163415756 @default.
• W2070303911 hasConcept C170493617 @default.
• W2070303911 hasConcept C185592680 @default.
• W2070303911 hasConcept C24998067 @default.
• W2070303911 hasConcept C2775910092 @default.
• W2070303911 hasConcept C2776090920 @default.
• W2070303911 hasConcept C2776663762 @default.
• W2070303911 hasConcept C2776885963 @default.
• W2070303911 hasConcept C2776991684 @default.
• W2070303911 hasConcept C2777676773 @default.
• W2070303911 hasConcept C2777952589 @default.
• W2070303911 hasConcept C2778151854 @default.
• W2070303911 hasConcept C2779768347 @default.
• W2070303911 hasConcept C2780253649 @default.
• W2070303911 hasConcept C2780561956 @default.
• W2070303911 hasConcept C2780648677 @default.
• W2070303911 hasConcept C55493867 @default.
• W2070303911 hasConcept C555293320 @default.
• W2070303911 hasConcept C71924100 @default.
• W2070303911 hasConcept C84393581 @default.
• W2070303911 hasConceptScore W2070303911C126322002 @default.
• W2070303911 hasConceptScore W2070303911C134018914 @default.
• W2070303911 hasConceptScore W2070303911C163415756 @default.
• W2070303911 hasConceptScore W2070303911C170493617 @default.
• W2070303911 hasConceptScore W2070303911C185592680 @default.
• W2070303911 hasConceptScore W2070303911C24998067 @default.
• W2070303911 hasConceptScore W2070303911C2775910092 @default.
• W2070303911 hasConceptScore W2070303911C2776090920 @default.
• W2070303911 hasConceptScore W2070303911C2776663762 @default.
• W2070303911 hasConceptScore W2070303911C2776885963 @default.
• W2070303911 hasConceptScore W2070303911C2776991684 @default.
• W2070303911 hasConceptScore W2070303911C2777676773 @default.
• W2070303911 hasConceptScore W2070303911C2777952589 @default.
• W2070303911 hasConceptScore W2070303911C2778151854 @default.
• W2070303911 hasConceptScore W2070303911C2779768347 @default.
• W2070303911 hasConceptScore W2070303911C2780253649 @default.
• W2070303911 hasConceptScore W2070303911C2780561956 @default.
• W2070303911 hasConceptScore W2070303911C2780648677 @default.
• W2070303911 hasConceptScore W2070303911C55493867 @default.
• W2070303911 hasConceptScore W2070303911C555293320 @default.
• W2070303911 hasConceptScore W2070303911C71924100 @default.
• W2070303911 hasConceptScore W2070303911C84393581 @default.
• W2070303911 hasLocation W20703039111 @default.
• W2070303911 hasLocation W20703039112 @default.
• W2070303911 hasLocation W20703039113 @default.
• W2070303911 hasLocation W20703039114 @default.

• next