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• W2070318887 abstract "To design a contact lens to treat and prevent fungal ocular infections.Curved contact lenses were created by encapsulating econazole-impregnated poly(lactic-co-glycolic) acid (PLGA) films in poly(hydroxyethyl methacrylate) (pHEMA) by ultraviolet photopolymerization. Release studies were conducted in phosphate-buffered saline at 37°C with continuous shaking. The contact lenses and their release media were tested in an antifungal assay against Candida albicans. Cross sections of the pre- and postrelease contact lenses were characterized by scanning electron microscopy and by Raman spectroscopy.Econazole-eluting contact lenses provided extended antifungal activity against Candida albicans fungi. Fungicidal activity varied in duration and effectiveness depending on the mass of the econazole-PLGA film encapsulated in the contact lens.An econazole-eluting contact lens could be used as a treatment for fungal ocular infections." @default.
• W2070318887 created "2016-06-24" @default.
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• W2070318887 date "2011-08-09" @default.
• W2070318887 modified "2023-09-26" @default.
• W2070318887 title "A Prototype Antifungal Contact Lens" @default.
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• W2070318887 doi "https://doi.org/10.1167/iovs.10-6935" @default.
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