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- W2070361497 endingPage "752" @default.
- W2070361497 startingPage "731" @default.
- W2070361497 abstract "Tumour cell dissemination is a complex process, depending on the ability of malignant cells to escape from the primary tumour and penetrate and flow through the bloodstream. Circulating tumour cells can adhere to the vessel wall, dissolve the basal lamina and extravasate, giving origin to metastases. Interactions between tumour cells, blood platelets and leukocytes favour tumour cell adhesion to the vessel wall, migration in extravascular spaces and growth in secondary sites. The biochemical and molecular mechanisms regulating tumour cell adhesion to the vessel wall and intercellular contacts have been studied extensively in recent years. Moreover, it has been shown that either tumour cells or blood cells release growth factors and inflammatory proteins, such as cytokines and chemokines, that may be involved in tumour cell migration and proliferation. Finally, tumour cells and cells of the surrounding tissue possess procoagulant and fibrinolytic properties that may be important in modulating the extracellular matrix around the tumour, to allow tumour cell invasion and progression. We have described the cell types (i.e. blood platelets, leukocytes, endothelial cells), the matrix components (i.e. fibronectin, thrombospondin and laminin) and the growth factors/cytokines (i.e. platelet-derived growth factor, transforming growth factor β, tumour necrosis factor) involved in these processes. In particular, we have described cell-cell and cell-matrix interactions, cell migration and release of growth factors, cytokines, chemotactic peptides and proteolytic enzymes. This survey has also considered a few innovative approaches for the prevention and cure of cancer and metastasis that are based on these new concepts." @default.
- W2070361497 created "2016-06-24" @default.
- W2070361497 creator A5061373096 @default.
- W2070361497 creator A5066251493 @default.
- W2070361497 creator A5088177513 @default.
- W2070361497 date "1993-09-01" @default.
- W2070361497 modified "2023-09-23" @default.
- W2070361497 title "10 The importance of blood cell-vessel wall interactions in tumour metastasis" @default.
- W2070361497 cites W1490705824 @default.
- W2070361497 cites W1504210656 @default.
- W2070361497 cites W1556092333 @default.
- W2070361497 cites W1805419512 @default.
- W2070361497 cites W1821237400 @default.
- W2070361497 cites W1969176764 @default.
- W2070361497 cites W1969281159 @default.
- W2070361497 cites W1971906639 @default.
- W2070361497 cites W1973064020 @default.
- W2070361497 cites W1973227330 @default.
- W2070361497 cites W1973630430 @default.
- W2070361497 cites W1977070858 @default.
- W2070361497 cites W1981581994 @default.
- W2070361497 cites W1981744194 @default.
- W2070361497 cites W1984952437 @default.
- W2070361497 cites W1987580335 @default.
- W2070361497 cites W1990097440 @default.
- W2070361497 cites W1998404570 @default.
- W2070361497 cites W2004241870 @default.
- W2070361497 cites W2004606612 @default.
- W2070361497 cites W2005165360 @default.
- W2070361497 cites W2005951667 @default.
- W2070361497 cites W2006677868 @default.
- W2070361497 cites W2008365877 @default.
- W2070361497 cites W2009406610 @default.
- W2070361497 cites W2010564529 @default.
- W2070361497 cites W2011497948 @default.
- W2070361497 cites W2015142675 @default.
- W2070361497 cites W2019416683 @default.
- W2070361497 cites W2021009141 @default.
- W2070361497 cites W2024102985 @default.
- W2070361497 cites W2025586500 @default.
- W2070361497 cites W2025806580 @default.
- W2070361497 cites W2026075546 @default.
- W2070361497 cites W2026939084 @default.
- W2070361497 cites W2027344845 @default.
- W2070361497 cites W2029231027 @default.
- W2070361497 cites W2031457609 @default.
- W2070361497 cites W2034713890 @default.
- W2070361497 cites W2034893493 @default.
- W2070361497 cites W2037726220 @default.
- W2070361497 cites W2040313839 @default.
- W2070361497 cites W2041158309 @default.
- W2070361497 cites W2042489614 @default.
- W2070361497 cites W2042775328 @default.
- W2070361497 cites W2044563284 @default.
- W2070361497 cites W2051736472 @default.
- W2070361497 cites W2052593722 @default.
- W2070361497 cites W2054703329 @default.
- W2070361497 cites W2055931533 @default.
- W2070361497 cites W2057729296 @default.
- W2070361497 cites W2057876887 @default.
- W2070361497 cites W2059810045 @default.
- W2070361497 cites W2060421910 @default.
- W2070361497 cites W2062604592 @default.
- W2070361497 cites W2063530769 @default.
- W2070361497 cites W2065314773 @default.
- W2070361497 cites W2069294982 @default.
- W2070361497 cites W2072810948 @default.
- W2070361497 cites W2076044573 @default.
- W2070361497 cites W2079022265 @default.
- W2070361497 cites W2079210929 @default.
- W2070361497 cites W2079588906 @default.
- W2070361497 cites W2081119605 @default.
- W2070361497 cites W2085951344 @default.
- W2070361497 cites W2093260238 @default.
- W2070361497 cites W2095498651 @default.
- W2070361497 cites W2101216734 @default.
- W2070361497 cites W2102084025 @default.
- W2070361497 cites W2105300288 @default.
- W2070361497 cites W2107067281 @default.
- W2070361497 cites W2109193962 @default.
- W2070361497 cites W2116441979 @default.
- W2070361497 cites W2123797864 @default.
- W2070361497 cites W2130561621 @default.
- W2070361497 cites W2131405836 @default.
- W2070361497 cites W2141298931 @default.
- W2070361497 cites W2143800769 @default.
- W2070361497 cites W2148371225 @default.
- W2070361497 cites W2152392662 @default.
- W2070361497 cites W2154552023 @default.
- W2070361497 cites W2165139012 @default.
- W2070361497 cites W2171854519 @default.
- W2070361497 cites W2176220887 @default.
- W2070361497 cites W23122061 @default.
- W2070361497 cites W2322553446 @default.
- W2070361497 cites W2398400257 @default.
- W2070361497 cites W2413612554 @default.
- W2070361497 cites W2421107533 @default.
- W2070361497 cites W2429485193 @default.