Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070362225> ?p ?o ?g. }
- W2070362225 endingPage "e29099" @default.
- W2070362225 startingPage "e29099" @default.
- W2070362225 abstract "Senescence, the state of permanent cell cycle arrest, has been associated with endothelial cell dysfunction and atherosclerosis. The cyclin dependent kinase inhibitors p21CIP1/WAF1 and p16INK4a govern the G1/S cell cycle checkpoint and are essential for determining whether a cell enters into an arrested state. The homeodomain transcription factor MEOX2 is an important regulator of vascular cell proliferation and is a direct transcriptional activator of both p21CIP1/WAF1 and p16INK4a. MEOX1 and MEOX2 have been shown to be partially functionally redundant during development, suggesting that they regulate similar target genes in vivo. We compared the ability of MEOX1 and MEOX2 to activate p21CIP1/WAF1 and p16INK4a expression and induce endothelial cell cycle arrest. Our results demonstrate for the first time that MEOX1 regulates the MEOX2 target genes p21CIP1/WAF1 and p16INK4a. In addition, increased expression of either of the MEOX homeodomain transcription factors leads to cell cycle arrest and endothelial cell senescence. Furthermore, we show that the mechanism of transcriptional activation of these cyclin dependent kinase inhibitor genes by MEOX1 and MEOX2 is distinct. MEOX1 and MEOX2 activate p16INK4a in a DNA binding dependent manner, whereas they induce p21CIP1/WAF1 in a DNA binding independent manner." @default.
- W2070362225 created "2016-06-24" @default.
- W2070362225 creator A5005445663 @default.
- W2070362225 creator A5005668372 @default.
- W2070362225 creator A5072972300 @default.
- W2070362225 creator A5073890351 @default.
- W2070362225 creator A5074826334 @default.
- W2070362225 date "2011-12-20" @default.
- W2070362225 modified "2023-09-25" @default.
- W2070362225 title "Mechanisms of MEOX1 and MEOX2 Regulation of the Cyclin Dependent Kinase Inhibitors p21CIP1/WAF1 and p16INK4a in Vascular Endothelial Cells" @default.
- W2070362225 cites W1966541965 @default.
- W2070362225 cites W1971079672 @default.
- W2070362225 cites W1974451402 @default.
- W2070362225 cites W1974801728 @default.
- W2070362225 cites W1977159737 @default.
- W2070362225 cites W1983395480 @default.
- W2070362225 cites W1984583623 @default.
- W2070362225 cites W1987520716 @default.
- W2070362225 cites W1987711136 @default.
- W2070362225 cites W1989335335 @default.
- W2070362225 cites W1992300748 @default.
- W2070362225 cites W1993300842 @default.
- W2070362225 cites W1999733778 @default.
- W2070362225 cites W2000170902 @default.
- W2070362225 cites W2000846615 @default.
- W2070362225 cites W2001669885 @default.
- W2070362225 cites W2007699624 @default.
- W2070362225 cites W2009580795 @default.
- W2070362225 cites W2015519364 @default.
- W2070362225 cites W2018183560 @default.
- W2070362225 cites W2023696449 @default.
- W2070362225 cites W2028339124 @default.
- W2070362225 cites W2030688236 @default.
- W2070362225 cites W2037362723 @default.
- W2070362225 cites W2038164081 @default.
- W2070362225 cites W2042297829 @default.
- W2070362225 cites W2046996819 @default.
- W2070362225 cites W2047816695 @default.
- W2070362225 cites W2054903577 @default.
- W2070362225 cites W2058014017 @default.
- W2070362225 cites W2059559668 @default.
- W2070362225 cites W2060913542 @default.
- W2070362225 cites W2061731694 @default.
- W2070362225 cites W2062764513 @default.
- W2070362225 cites W2072088194 @default.
- W2070362225 cites W2073470461 @default.
- W2070362225 cites W2075403702 @default.
- W2070362225 cites W2076059465 @default.
- W2070362225 cites W2080193680 @default.
- W2070362225 cites W2088716619 @default.
- W2070362225 cites W2091206431 @default.
- W2070362225 cites W2104908670 @default.
- W2070362225 cites W2107689453 @default.
- W2070362225 cites W2108106334 @default.
- W2070362225 cites W2108747532 @default.
- W2070362225 cites W2111622139 @default.
- W2070362225 cites W2112150809 @default.
- W2070362225 cites W2113072982 @default.
- W2070362225 cites W2128093079 @default.
- W2070362225 cites W2135717026 @default.
- W2070362225 cites W2151829896 @default.
- W2070362225 cites W2154622533 @default.
- W2070362225 cites W2159745709 @default.
- W2070362225 cites W2164022766 @default.
- W2070362225 cites W2169814977 @default.
- W2070362225 cites W2331676402 @default.
- W2070362225 doi "https://doi.org/10.1371/journal.pone.0029099" @default.
- W2070362225 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3243699" @default.
- W2070362225 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22206000" @default.
- W2070362225 hasPublicationYear "2011" @default.
- W2070362225 type Work @default.
- W2070362225 sameAs 2070362225 @default.
- W2070362225 citedByCount "46" @default.
- W2070362225 countsByYear W20703622252012 @default.
- W2070362225 countsByYear W20703622252013 @default.
- W2070362225 countsByYear W20703622252014 @default.
- W2070362225 countsByYear W20703622252015 @default.
- W2070362225 countsByYear W20703622252016 @default.
- W2070362225 countsByYear W20703622252017 @default.
- W2070362225 countsByYear W20703622252018 @default.
- W2070362225 countsByYear W20703622252019 @default.
- W2070362225 countsByYear W20703622252020 @default.
- W2070362225 countsByYear W20703622252021 @default.
- W2070362225 countsByYear W20703622252022 @default.
- W2070362225 countsByYear W20703622252023 @default.
- W2070362225 crossrefType "journal-article" @default.
- W2070362225 hasAuthorship W2070362225A5005445663 @default.
- W2070362225 hasAuthorship W2070362225A5005668372 @default.
- W2070362225 hasAuthorship W2070362225A5072972300 @default.
- W2070362225 hasAuthorship W2070362225A5073890351 @default.
- W2070362225 hasAuthorship W2070362225A5074826334 @default.
- W2070362225 hasBestOaLocation W20703622251 @default.
- W2070362225 hasConcept C104317684 @default.
- W2070362225 hasConcept C105696609 @default.
- W2070362225 hasConcept C143425029 @default.
- W2070362225 hasConcept C153911025 @default.
- W2070362225 hasConcept C165864922 @default.
- W2070362225 hasConcept C184235292 @default.