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• W2070364248 abstract "<b>Context:</b> Investigating the adverse effects of oral hormone replacement therapy (HRT), the clinical effectiveness of alternative combinations and route of administrations. <b>Aim:</b> To compare the effects of intranasal and transdermal 17β-estradiol combined with vaginal progesterone on vasomotor symptoms and vaginal cytology. <b>Settings and Design: </b> A 12-week, prospective, randomized comparative study was conducted between July 2005 and September 2006. <b>Materials and Methods:</b> Eighty postmenopausal women aged between 42-57 years, who had scores of ≥1.7 on the menopause rating scale-I (MRS-I) items 1-6, were randomly assigned to receive intranasal (300 µg/day, <i> n</i> =40) or transdermal (50 µg/day, <i> n</i> =40) 17β-estradiol continuously. All patients also received a vaginal progesterone gel twice weekly. Vasomotor symptoms were evaluated at weeks 0, 4, 8 and 12. Vaginal maturation index (VMI) was evaluated at weeks 0 and 12 of the study. <b>Statistical Analyses:</b> The Mann-Whitney <i> U</i> and the Wilcoxon tests were used. <i> P </i> <0.05 was regarded as significant. <b>Results: </b> Thirty-two women in the intranasal and 29 women in the transdermal group completed the study. The total score of the MRS, the sum-scores of Factor 1 HOT FLUSHES and Factor 2 PSYCHE significantly decreased in both groups at week 4. Factor 3 ATROPHY scores significantly decreased only in the transdermal group at week 12. The VMI showed no changes within and between the two groups at the end of the study. <b>Conclusion:</b> Intranasal and transdermal 17β-estradiol combined with vaginal progesterone gel as a continuous HRT caused a similar decrease in vasomotor symptoms but did not have any significant effect on VMI after 12 weeks of treatment in this study population." @default.
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• W2070364248 date "2007-01-01" @default.
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• W2070364248 title "A prospective randomized comparative study of the effects of intranasal and transdermal 17 β-estradiol on postmenopausal symptoms and vaginal cytology" @default.
• W2070364248 doi "https://doi.org/10.4103/0022-3859.33966" @default.
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