Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070375238> ?p ?o ?g. }
- W2070375238 endingPage "19672" @default.
- W2070375238 startingPage "19661" @default.
- W2070375238 abstract "Campylobacter jejuni is a leading cause of acute gastroenteritis. C. jejuni lipooligosaccharide (LOS) is a potent activator of Toll-like receptor (TLR) 4-mediated innate immunity. Structural variations of the LOS have been previously reported in the oligosaccharide (OS) moiety, the disaccharide lipid A (LA) backbone, and the phosphorylation of the LA. Here, we studied LOS structural variation between C. jejuni strains associated with different ecological sources and analyzed their ability to activate TLR4 function. MALDI-TOF MS was performed to characterize structural variation in both the OS and LA among 15 different C. jejuni isolates. Cytokine induction in THP-1 cells and primary monocytes was correlated with LOS structural variation in each strain. Additionally, structural variation was correlated with the source of each strain. OS sialylation, increasing abundance of LA d-glucosamine versus 2,3-diamino-2,3-dideoxy-d-glucose, and phosphorylation status all correlated with TLR4 activation as measured in THP-1 cells and monocytes. Importantly, LOS-induced inflammatory responses were similar to those elicited by live bacteria, highlighting the prominent contribution of the LOS component in driving host immunity. OS sialylation status but not LA structure showed significant association with strains clustering with livestock sources. Our study highlights how variations in three structural components of C. jejuni LOS alter TLR4 activation and consequent monocyte activation." @default.
- W2070375238 created "2016-06-24" @default.
- W2070375238 creator A5006037710 @default.
- W2070375238 creator A5015010568 @default.
- W2070375238 creator A5019987721 @default.
- W2070375238 creator A5023116254 @default.
- W2070375238 creator A5035234881 @default.
- W2070375238 creator A5046020899 @default.
- W2070375238 creator A5052990907 @default.
- W2070375238 creator A5078486352 @default.
- W2070375238 date "2013-07-01" @default.
- W2070375238 modified "2023-10-16" @default.
- W2070375238 title "Campylobacter jejuni Lipooligosaccharide Sialylation, Phosphorylation, and Amide/Ester Linkage Modifications Fine-tune Human Toll-like Receptor 4 Activation" @default.
- W2070375238 cites W1538572377 @default.
- W2070375238 cites W1576934911 @default.
- W2070375238 cites W1976891658 @default.
- W2070375238 cites W1979086877 @default.
- W2070375238 cites W1981558302 @default.
- W2070375238 cites W1985199672 @default.
- W2070375238 cites W1992066825 @default.
- W2070375238 cites W1998453083 @default.
- W2070375238 cites W1999254509 @default.
- W2070375238 cites W2012662786 @default.
- W2070375238 cites W2028417315 @default.
- W2070375238 cites W2039347160 @default.
- W2070375238 cites W2052800627 @default.
- W2070375238 cites W2054198559 @default.
- W2070375238 cites W2065134483 @default.
- W2070375238 cites W2087041328 @default.
- W2070375238 cites W2095619327 @default.
- W2070375238 cites W2098157455 @default.
- W2070375238 cites W2100334884 @default.
- W2070375238 cites W2102484955 @default.
- W2070375238 cites W2109975723 @default.
- W2070375238 cites W2110076909 @default.
- W2070375238 cites W2110468713 @default.
- W2070375238 cites W2112879979 @default.
- W2070375238 cites W2117239946 @default.
- W2070375238 cites W2123958685 @default.
- W2070375238 cites W2127172172 @default.
- W2070375238 cites W2127934565 @default.
- W2070375238 cites W2128897591 @default.
- W2070375238 cites W2129319296 @default.
- W2070375238 cites W2134080655 @default.
- W2070375238 cites W2137966873 @default.
- W2070375238 cites W2139833332 @default.
- W2070375238 cites W2142143757 @default.
- W2070375238 cites W2142992860 @default.
- W2070375238 cites W2146167147 @default.
- W2070375238 cites W2160993282 @default.
- W2070375238 cites W2164237791 @default.
- W2070375238 cites W2171976568 @default.
- W2070375238 cites W2172179018 @default.
- W2070375238 cites W4233970575 @default.
- W2070375238 cites W4240236037 @default.
- W2070375238 cites W4376848200 @default.
- W2070375238 doi "https://doi.org/10.1074/jbc.m113.468298" @default.
- W2070375238 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3707672" @default.
- W2070375238 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23629657" @default.
- W2070375238 hasPublicationYear "2013" @default.
- W2070375238 type Work @default.
- W2070375238 sameAs 2070375238 @default.
- W2070375238 citedByCount "40" @default.
- W2070375238 countsByYear W20703752382013 @default.
- W2070375238 countsByYear W20703752382014 @default.
- W2070375238 countsByYear W20703752382015 @default.
- W2070375238 countsByYear W20703752382016 @default.
- W2070375238 countsByYear W20703752382017 @default.
- W2070375238 countsByYear W20703752382018 @default.
- W2070375238 countsByYear W20703752382019 @default.
- W2070375238 countsByYear W20703752382020 @default.
- W2070375238 countsByYear W20703752382021 @default.
- W2070375238 countsByYear W20703752382022 @default.
- W2070375238 countsByYear W20703752382023 @default.
- W2070375238 crossrefType "journal-article" @default.
- W2070375238 hasAuthorship W2070375238A5006037710 @default.
- W2070375238 hasAuthorship W2070375238A5015010568 @default.
- W2070375238 hasAuthorship W2070375238A5019987721 @default.
- W2070375238 hasAuthorship W2070375238A5023116254 @default.
- W2070375238 hasAuthorship W2070375238A5035234881 @default.
- W2070375238 hasAuthorship W2070375238A5046020899 @default.
- W2070375238 hasAuthorship W2070375238A5052990907 @default.
- W2070375238 hasAuthorship W2070375238A5078486352 @default.
- W2070375238 hasBestOaLocation W20703752381 @default.
- W2070375238 hasConcept C11960822 @default.
- W2070375238 hasConcept C136449434 @default.
- W2070375238 hasConcept C144464004 @default.
- W2070375238 hasConcept C170493617 @default.
- W2070375238 hasConcept C185592680 @default.
- W2070375238 hasConcept C203014093 @default.
- W2070375238 hasConcept C2776070231 @default.
- W2070375238 hasConcept C2776709828 @default.
- W2070375238 hasConcept C2776957140 @default.
- W2070375238 hasConcept C2778754761 @default.
- W2070375238 hasConcept C2779910956 @default.
- W2070375238 hasConcept C523546767 @default.
- W2070375238 hasConcept C54355233 @default.
- W2070375238 hasConcept C55493867 @default.