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- W2070403025 abstract "A 49-year-old man with a 16-year history of adult-onset X-linked adrenoleukodystrophy was admitted because of aspiration pneumonia. He was comatose with obvious akinesia and positive plantar reflexes. Magnetic resonance imaging (MRI) on admission showed abnormal intensities in the middle cerebellar peduncles, pons and internal capsule (Fig. 1). Three weeks later, his respiratory rhythm deteriorated to Cheyne–Stokes respiration, and then abnormal intensities on MRI expanded dramatically from the internal capsule to the precentral gyrus (Fig. 1). These changes might not be cytotoxic edema, because diffusion-weighted imaging and apparent diffusion coefficient maps also showed high-intensity in these places. Abnormal intensities on MRI were further worsened after 1 year. Involvement of the corticospinal tract has been recognized as the most common MRI abnormality in adult-onset adult-onset X-linked adrenoleukodystrophy, and has been thought to follow a benign course with a lack of progression.1 To the best of our knowledge, this represents the first report of dramatic progression of corticospinal tract lesions within a short duration. The precise mechanisms underlying this rapid progression are unknown; however, we considered that inflammation caused by aspiration pneumonia might have contributed to the drastic dying-back or Waller degeneration of the corticospinal tract." @default.
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- W2070403025 date "2014-11-27" @default.
- W2070403025 modified "2023-09-23" @default.
- W2070403025 title "Dynamic change of corticospinal tract in a case of adult-onset X-linked adrenoleukodystrophy" @default.
- W2070403025 cites W2040981313 @default.
- W2070403025 doi "https://doi.org/10.1111/ncn3.131" @default.
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