Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070435400> ?p ?o ?g. }
- W2070435400 endingPage "3474" @default.
- W2070435400 startingPage "3464" @default.
- W2070435400 abstract "Abstract Objective To explore the role that implanted mesenchymal stem cells may play in tissue repair or regeneration of the injured joint, by delivery of an autologous preparation of stem cells to caprine knee joints following induction of osteoarthritis (OA). Methods Adult stem cells were isolated from caprine bone marrow, expanded in culture, and transduced to express green fluorescent protein. OA was induced unilaterally in the knee joint of donor animals by complete excision of the medial meniscus and resection of the anterior cruciate ligament. After 6 weeks, a single dose of 10 million autologous cells suspended in a dilute solution of sodium hyaluronan was delivered to the injured knee by direct intraarticular injection. Control animals received sodium hyaluronan alone. Results In cell‐treated joints, there was evidence of marked regeneration of the medial meniscus, and implanted cells were detected in the newly formed tissue. Degeneration of the articular cartilage, osteophytic remodeling, and subchondral sclerosis were reduced in cell‐treated joints compared with joints treated with vehicle alone without cells. There was no evidence of repair of the ligament in any of the joints. Conclusion Local delivery of adult mesenchymal stem cells to injured joints stimulates regeneration of meniscal tissue and retards the progressive destruction normally seen in this model of OA." @default.
- W2070435400 created "2016-06-24" @default.
- W2070435400 creator A5018870140 @default.
- W2070435400 creator A5026111008 @default.
- W2070435400 creator A5030012610 @default.
- W2070435400 creator A5076064769 @default.
- W2070435400 date "2003-12-01" @default.
- W2070435400 modified "2023-10-12" @default.
- W2070435400 title "Stem cell therapy in a caprine model of osteoarthritis" @default.
- W2070435400 cites W1508246447 @default.
- W2070435400 cites W1522229466 @default.
- W2070435400 cites W1548494467 @default.
- W2070435400 cites W1750539994 @default.
- W2070435400 cites W1908249423 @default.
- W2070435400 cites W1964596059 @default.
- W2070435400 cites W1967194752 @default.
- W2070435400 cites W1967824602 @default.
- W2070435400 cites W1968055329 @default.
- W2070435400 cites W1968746947 @default.
- W2070435400 cites W1969221593 @default.
- W2070435400 cites W1977950302 @default.
- W2070435400 cites W1978969115 @default.
- W2070435400 cites W1986300999 @default.
- W2070435400 cites W1988349655 @default.
- W2070435400 cites W1991415492 @default.
- W2070435400 cites W1992935708 @default.
- W2070435400 cites W1996884864 @default.
- W2070435400 cites W2000097208 @default.
- W2070435400 cites W2001419792 @default.
- W2070435400 cites W2002320509 @default.
- W2070435400 cites W2005829701 @default.
- W2070435400 cites W2008541403 @default.
- W2070435400 cites W2009040628 @default.
- W2070435400 cites W2010335941 @default.
- W2070435400 cites W2014673628 @default.
- W2070435400 cites W2020309083 @default.
- W2070435400 cites W2024335985 @default.
- W2070435400 cites W2025153838 @default.
- W2070435400 cites W2027736364 @default.
- W2070435400 cites W2029247294 @default.
- W2070435400 cites W2032181767 @default.
- W2070435400 cites W2037719060 @default.
- W2070435400 cites W2049521062 @default.
- W2070435400 cites W2050682751 @default.
- W2070435400 cites W2052621786 @default.
- W2070435400 cites W2055099160 @default.
- W2070435400 cites W2059836468 @default.
- W2070435400 cites W2063460492 @default.
- W2070435400 cites W2068135722 @default.
- W2070435400 cites W2084652820 @default.
- W2070435400 cites W2091395040 @default.
- W2070435400 cites W2096059782 @default.
- W2070435400 cites W2100052222 @default.
- W2070435400 cites W2113205297 @default.
- W2070435400 cites W2115473500 @default.
- W2070435400 cites W2130276214 @default.
- W2070435400 cites W2144268541 @default.
- W2070435400 cites W2151848959 @default.
- W2070435400 cites W2333754331 @default.
- W2070435400 cites W2408834015 @default.
- W2070435400 cites W4241343866 @default.
- W2070435400 cites W4251900046 @default.
- W2070435400 doi "https://doi.org/10.1002/art.11365" @default.
- W2070435400 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14673997" @default.
- W2070435400 hasPublicationYear "2003" @default.
- W2070435400 type Work @default.
- W2070435400 sameAs 2070435400 @default.
- W2070435400 citedByCount "968" @default.
- W2070435400 countsByYear W20704354002012 @default.
- W2070435400 countsByYear W20704354002013 @default.
- W2070435400 countsByYear W20704354002014 @default.
- W2070435400 countsByYear W20704354002015 @default.
- W2070435400 countsByYear W20704354002016 @default.
- W2070435400 countsByYear W20704354002017 @default.
- W2070435400 countsByYear W20704354002018 @default.
- W2070435400 countsByYear W20704354002019 @default.
- W2070435400 countsByYear W20704354002020 @default.
- W2070435400 countsByYear W20704354002021 @default.
- W2070435400 countsByYear W20704354002022 @default.
- W2070435400 countsByYear W20704354002023 @default.
- W2070435400 crossrefType "journal-article" @default.
- W2070435400 hasAuthorship W2070435400A5018870140 @default.
- W2070435400 hasAuthorship W2070435400A5026111008 @default.
- W2070435400 hasAuthorship W2070435400A5030012610 @default.
- W2070435400 hasAuthorship W2070435400A5076064769 @default.
- W2070435400 hasConcept C105702510 @default.
- W2070435400 hasConcept C120665830 @default.
- W2070435400 hasConcept C121332964 @default.
- W2070435400 hasConcept C123012128 @default.
- W2070435400 hasConcept C13685319 @default.
- W2070435400 hasConcept C141071460 @default.
- W2070435400 hasConcept C142724271 @default.
- W2070435400 hasConcept C171056886 @default.
- W2070435400 hasConcept C189178095 @default.
- W2070435400 hasConcept C198826908 @default.
- W2070435400 hasConcept C202751555 @default.
- W2070435400 hasConcept C204787440 @default.
- W2070435400 hasConcept C20875687 @default.