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• W2070443579 abstract "Trauma is a major contributor to the global burden of disease (WHO, 2009). Haemorrhage following injury is the leading cause of preventable death (Gruen et al., 2012), with many patients dying in the first 24 hours following the traumatic event (Borgman et al., 2007). Early phase care in prehospital (PHC) and emergency department (ED) settings focuses on timely recognition and control of haemorrhage. Many trauma systems have introduced major haemorrhage protocols (MHP) to help with the rapid identification of bleeding trauma patients and ensure that appropriate blood products are delivered (Khan et al., 2013). Haemorrhage following injury is strongly associated with early coagulation system dysfunction, known as acute traumatic coagulopathy (ATC) (Davenport, 2013). Approximately one quarter of all severely injured patients are reported to be coagulopathic on arrival to hospital (Brohi et al., 2003). ATC is a complex system of changes to normal clotting responses, occurring early in the patients’ clinical course. It causes increased mortality, and for patients who survive the first hours following injury, ATC is a strong predictor of in-hospital morbidity such as organ failure or infection (Cole et al., 2013). Short scene to ED times, early haemorrhage control and considered use of blood and clotting products are essential interventions for the management of bleeding, potentially coagulopathic patients. Additionally, the antifibrinolytic drug Tranexamic acid (TXA) is reported to be beneficial in the management of bleeding and ATC (Cap et al., 2011). Many trauma systems have included TXA in major haemorrhage or ‘code red’ protocols as a result of recent evidence and European guidance (Spahn et al., 2013). This paper aims to describe ATC and discuss the use of TXA in its management. 2. Overview of acute traumatic coagulopathy" @default.
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• W2070443579 date "2015-01-01" @default.
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• W2070443579 title "Early tranexamic acid use in trauma haemorrhage: Why do we give it and which patients benefit most?" @default.
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• W2070443579 doi "https://doi.org/10.1016/j.ienj.2014.03.004" @default.
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