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• W2070444280 abstract "Transplant nursing brings with it a host of patient issues including but not limited to clinical, social, emotional, and financial. As transplant nurses it is our responsibility to provide our patients with the best care available. One of the most impacting complications in the hematopoietic cell transplant (HCT) patient is oral mucositis. Oral mucositis brings with it significant effects on the patient’s clinical course such as pain, anorexia, dysguesia, insomnia, and infection. Background/Purpose Our department’s standard for oral care in the HCT patient included a 0.4% fluoride toothpaste (Gel-Kam™) and 0.9% saline mouth rinse every 2 hours while awake. Beginning in November of 2005 we initiated the use of a high concentration fluoride rinse (MEDOral™) daily in addition to our standard regimen. We noticed over a period of months a decrease in the severity of oral mucositis. Retrospectively, we looked at twenty-five (14 autologous and 11 allogeneic) patients to evaluate the addition of MEDOral™. Patients conditioning regimens varied and included agents known to increase risk of mucositis. A preliminary evaluation showed twelve of the twenty-five patients had evidence of oral mucositis, grade I-II. Though there appears to be a decrease in the severity/frequency of oral mucositis in these patients, all twelve required some type of patient controlled analgesia for grade III-IV esophagitis. These findings indicate that the addition of the high concentration fluoride rinse may benefit HCT patients and potentially decrease the severity and frequency of oral mucositis. Plan: We plan to conduct a prospective study on the use of high concentration fluoride rinse in the HCT patients.Tabled 1Conditioning Regimens (n)Autologous (14)Allogeneic (11)HD Melphalan (7)Bu/Flu/Cam (1)BEAM-R (6)Flu/Mel/Cam (2)BEAM (1)Cy/TBI/Cam (3)Bu/Flu/MTX (1)Cy/TBI/MTX (2)Bu/Cy/MTX (1)Mel/TBI (1)Abbreviations: HD-high dose; BEAM- carmustine, etoposide, cytarabine, melphalan; R-Rituximab; Bu-busulfan; Flu-fludarabine; Cam- Alemtuzumab; Mel- melphalan; Cy- cyclophosphamide; TBI- total body irradiation; MTX- methotrexate Open table in a new tab Abbreviations: HD-high dose; BEAM- carmustine, etoposide, cytarabine, melphalan; R-Rituximab; Bu-busulfan; Flu-fludarabine; Cam- Alemtuzumab; Mel- melphalan; Cy- cyclophosphamide; TBI- total body irradiation; MTX- methotrexate" @default.
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• W2070444280 date "2007-02-01" @default.
• W2070444280 modified "2023-09-26" @default.
• W2070444280 title "381: Prophylactic use of high concentration fluoride rinse in the hematopoietic cell transplant patient" @default.
• W2070444280 doi "https://doi.org/10.1016/j.bbmt.2007.01.011" @default.
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