Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070450503> ?p ?o ?g. }
- W2070450503 endingPage "1572" @default.
- W2070450503 startingPage "1557" @default.
- W2070450503 abstract "Shp2 (Src homology 2 domain-containing protein tyrosine phosphatase 2) regulates neural cell differentiation. It is also expressed in postmitotic neurons, however, and mutations of Shp2 are associated with clinical syndromes characterized by mental retardation. Here we show that conditional-knockout (cKO) mice lacking Shp2 specifically in postmitotic forebrain neurons manifest abnormal behavior, including hyperactivity. Novelty-induced expression of immediate-early genes and activation of extracellular-signal-regulated kinase (Erk) were attenuated in the cerebral cortex and hippocampus of Shp2 cKO mice, suggestive of reduced neuronal activity. In contrast, ablation of Shp2 enhanced high-K(+)-induced Erk activation in both cultured cortical neurons and synaptosomes, whereas it inhibited that induced by brain-derived growth factor in cultured neurons. Posttetanic potentiation and paired-pulse facilitation were attenuated and enhanced, respectively, in hippocampal slices from Shp2 cKO mice. The mutant mice also manifested transient impairment of memory formation in the Morris water maze. Our data suggest that Shp2 contributes to regulation of Erk activation and synaptic plasticity in postmitotic forebrain neurons and thereby controls locomotor activity and memory formation." @default.
- W2070450503 created "2016-06-24" @default.
- W2070450503 creator A5001341469 @default.
- W2070450503 creator A5003799324 @default.
- W2070450503 creator A5009161905 @default.
- W2070450503 creator A5011247022 @default.
- W2070450503 creator A5013411787 @default.
- W2070450503 creator A5040350752 @default.
- W2070450503 creator A5060764523 @default.
- W2070450503 creator A5071680544 @default.
- W2070450503 creator A5073680568 @default.
- W2070450503 creator A5076158060 @default.
- W2070450503 creator A5081647213 @default.
- W2070450503 creator A5083565159 @default.
- W2070450503 creator A5086525882 @default.
- W2070450503 date "2015-05-01" @default.
- W2070450503 modified "2023-10-14" @default.
- W2070450503 title "Shp2 in Forebrain Neurons Regulates Synaptic Plasticity, Locomotion, and Memory Formation in Mice" @default.
- W2070450503 cites W1509825554 @default.
- W2070450503 cites W1581543871 @default.
- W2070450503 cites W1963956528 @default.
- W2070450503 cites W1966100684 @default.
- W2070450503 cites W1967061503 @default.
- W2070450503 cites W1967318257 @default.
- W2070450503 cites W1971572958 @default.
- W2070450503 cites W1973275441 @default.
- W2070450503 cites W1975727393 @default.
- W2070450503 cites W1976509949 @default.
- W2070450503 cites W1979722180 @default.
- W2070450503 cites W1980967004 @default.
- W2070450503 cites W1981577886 @default.
- W2070450503 cites W1981695205 @default.
- W2070450503 cites W1986755373 @default.
- W2070450503 cites W2001732968 @default.
- W2070450503 cites W2009641462 @default.
- W2070450503 cites W2009880851 @default.
- W2070450503 cites W2009987256 @default.
- W2070450503 cites W2011235662 @default.
- W2070450503 cites W2019016101 @default.
- W2070450503 cites W2019100219 @default.
- W2070450503 cites W2025768025 @default.
- W2070450503 cites W2028133356 @default.
- W2070450503 cites W2028517758 @default.
- W2070450503 cites W2029458121 @default.
- W2070450503 cites W2034101922 @default.
- W2070450503 cites W2034697967 @default.
- W2070450503 cites W2037111632 @default.
- W2070450503 cites W2038680295 @default.
- W2070450503 cites W2043625750 @default.
- W2070450503 cites W2049847654 @default.
- W2070450503 cites W2054086319 @default.
- W2070450503 cites W2056024459 @default.
- W2070450503 cites W2059164249 @default.
- W2070450503 cites W2066551977 @default.
- W2070450503 cites W2067654943 @default.
- W2070450503 cites W2069312841 @default.
- W2070450503 cites W2070058327 @default.
- W2070450503 cites W2070094949 @default.
- W2070450503 cites W2072138658 @default.
- W2070450503 cites W2075361934 @default.
- W2070450503 cites W2076636373 @default.
- W2070450503 cites W2077320328 @default.
- W2070450503 cites W2081635903 @default.
- W2070450503 cites W2083048709 @default.
- W2070450503 cites W2083734828 @default.
- W2070450503 cites W2086694643 @default.
- W2070450503 cites W2088485943 @default.
- W2070450503 cites W2089299823 @default.
- W2070450503 cites W2094548766 @default.
- W2070450503 cites W2097354837 @default.
- W2070450503 cites W2100876024 @default.
- W2070450503 cites W2102501457 @default.
- W2070450503 cites W2108188100 @default.
- W2070450503 cites W2109091674 @default.
- W2070450503 cites W2109807917 @default.
- W2070450503 cites W2119184935 @default.
- W2070450503 cites W2134895450 @default.
- W2070450503 cites W2135241917 @default.
- W2070450503 cites W2144750899 @default.
- W2070450503 cites W2146918064 @default.
- W2070450503 cites W2153397468 @default.
- W2070450503 cites W2153592313 @default.
- W2070450503 cites W2154438447 @default.
- W2070450503 cites W2157153072 @default.
- W2070450503 cites W2169826947 @default.
- W2070450503 cites W3192453023 @default.
- W2070450503 doi "https://doi.org/10.1128/mcb.01339-14" @default.
- W2070450503 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4387209" @default.
- W2070450503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25713104" @default.
- W2070450503 hasPublicationYear "2015" @default.
- W2070450503 type Work @default.
- W2070450503 sameAs 2070450503 @default.
- W2070450503 citedByCount "27" @default.
- W2070450503 countsByYear W20704505032016 @default.
- W2070450503 countsByYear W20704505032017 @default.
- W2070450503 countsByYear W20704505032018 @default.
- W2070450503 countsByYear W20704505032019 @default.
- W2070450503 countsByYear W20704505032020 @default.