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• W2070460003 abstract "Study objective We wished to determine if magnesium infusion would improve respiratory muscle function in long-term ventilated patients even in the absence of hypomagnesemia. Design Prospective study of mechanically ventilated patients using a double-blind crossover design. Setting A combined medical-surgical ICU of a university teaching hospital. Patients Twenty-one separate admissions to the ICU in 20 patients were studied. Patients who were selected had been intubated and mechanically ventilated for at least 6 days with the admitting diagnosis of respiratory failure. Interventions: Twelve patients received 6 g MgSO4 intravenous (IV) infusion over 16 h on day 1 followed by placebo infusion on day 2. Nine patients received placebo on day 1 followed by MgSO4 (6 g IV) on day 2. Measurements and main results We measured vital capacity (VC), maximal inspiratory pressure (Pimax) and maximal expiratory pressure (PEmax) in all patients. There were no significant differences in Pimax (37 ± 14 vs 42 ± 20 cm H2O), PEmax (59 ±32 vs 61 ±38 cm H2O), and VC (850 ± 460 vs 960 ± 490 ml) comparing values before and after magnesium infusion. We could not find a subgroup of patients with a marked improvement in PImax or PEmax. Conclusions In patients requiring mechanical ventilation for respiratory failure, magnesium infusion is not associated with increased respiratory muscle strength. Although a trial of MgSO4 administration may be considered for patients with difficulty weaning from mechanical ventilation, it is unlikely to result in clinical improvement. We wished to determine if magnesium infusion would improve respiratory muscle function in long-term ventilated patients even in the absence of hypomagnesemia. Prospective study of mechanically ventilated patients using a double-blind crossover design. A combined medical-surgical ICU of a university teaching hospital. Twenty-one separate admissions to the ICU in 20 patients were studied. Patients who were selected had been intubated and mechanically ventilated for at least 6 days with the admitting diagnosis of respiratory failure. Interventions: Twelve patients received 6 g MgSO4 intravenous (IV) infusion over 16 h on day 1 followed by placebo infusion on day 2. Nine patients received placebo on day 1 followed by MgSO4 (6 g IV) on day 2. We measured vital capacity (VC), maximal inspiratory pressure (Pimax) and maximal expiratory pressure (PEmax) in all patients. There were no significant differences in Pimax (37 ± 14 vs 42 ± 20 cm H2O), PEmax (59 ±32 vs 61 ±38 cm H2O), and VC (850 ± 460 vs 960 ± 490 ml) comparing values before and after magnesium infusion. We could not find a subgroup of patients with a marked improvement in PImax or PEmax. In patients requiring mechanical ventilation for respiratory failure, magnesium infusion is not associated with increased respiratory muscle strength. Although a trial of MgSO4 administration may be considered for patients with difficulty weaning from mechanical ventilation, it is unlikely to result in clinical improvement." @default.
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• W2070460003 title "The Lack of Effect of Routine Magnesium Administration on Respiratory Function in Mechanically Ventilated Patients" @default.
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• W2070460003 doi "https://doi.org/10.1378/chest.104.2.536" @default.
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