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- W2070464124 abstract "Abstract The interaction of montmorillonite with sotalol hydrochloride (4-(1-hydroxy- N -isopropylaminoethyl) methane sulfanilide) was studied by means of adsorption isotherms, XRD and IR spectroscopy. The amount of sotalol adsorbed depended on pH, the maximum amount adsorbed (0·56 mEq g −1 ) being considerably less than the exchange capacity of the mineral (0·80 mEq g −1 ). XRD and IR data revealed that the sotalol is adsorbed into the interlayer space, forming a monolayer complex with a d 001 spacing of 17·7 Å, and that the mechanisms involved are cation exchange and ion-dipole interactions. Experiments on the in vitro desorption of the drug from the sotalol-montmorillonite complex indicated that desorption is affected by pH, by the salt concentration of the electrolyte, and by the elimination rate of the desorbed organic cations." @default.
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- W2070464124 date "1987-06-01" @default.
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- W2070464124 title "Adsorption-desorption of sotalol hydrochloride by Na-montmorillonite" @default.
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- W2070464124 doi "https://doi.org/10.1180/claymin.1987.022.2.01" @default.
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