FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070469043> ?p ?o ?g. }

• W2070469043 endingPage "139" @default.
• W2070469043 startingPage "130" @default.
• W2070469043 abstract "The antineutrophil cytoplasmic antibody (ANCA)-positive vasculitides are characterized by a necrotizing vasculitis of small vessels with neutrophil infiltration. The reasons behind the selectivity for small vessels remain unclear, but may relate to the necessity for neutrophils to deform in order to pass through capillaries. The resistance to deformation of neutrophils largely arises from their actin cytoskeleton. It is hypothesized that ANCA, by inducing actin polymerization, increases neutrophil rigidity and contributes to their sequestration in capillaries.To test this hypothesis, neutrophils were treated with IgG-ANCA and the following characterizations: formation of filamentous F-actin (by flow cytometry); changes in morphology (by fluorescence and electron microscopy); and the potential to obstruct microvessels (by measuring entry times into micropipettes with comparable diameters to capillaries). The neutrophil signaling mechanisms activated by IgG-ANCA were investigated using blocking antibodies to Fcgamma receptors and inhibitors of tyrosine phosphorylation. Protein tyrosine phosphorylation was examined by immunoblotting of cell lysates, and calcium fluxes were measured by spectrofluorimetry of Fura-2 pentakis (acetoxymethyl) ester (Fura 2-AM) labeled neutrophils.IgG-ANCA led to a significant dose-dependent actin polymerization over about 10 minutes. Over the same period, neutrophils became distorted in shape and more resistant to micropipette aspiration. Treatment with normal IgG caused less marked and delayed changes in these parameters. Actin polymerization required engagement of FcgammaRIIa receptor, tyrosine phosphorylation, and calcium fluxes.These novel findings reveal signaling mechanisms that underlie ANCA-induced actin polymerization and might explain the predilection for small vessels in IgG-ANCA-associated vasculitis." @default.
• W2070469043 created "2016-06-24" @default.
• W2070469043 creator A5026935880 @default.
• W2070469043 creator A5054014010 @default.
• W2070469043 creator A5071833047 @default.
• W2070469043 creator A5073356850 @default.
• W2070469043 creator A5090039049 @default.
• W2070469043 date "2005-01-01" @default.
• W2070469043 modified "2023-10-16" @default.
• W2070469043 title "ANCA-induced neutrophil F-actin polymerization: Implications for microvascular inflammation" @default.
• W2070469043 cites W1486844399 @default.
• W2070469043 cites W1596601321 @default.
• W2070469043 cites W1606716377 @default.
• W2070469043 cites W1677082860 @default.
• W2070469043 cites W1779123347 @default.
• W2070469043 cites W1871950693 @default.
• W2070469043 cites W1884780861 @default.
• W2070469043 cites W1915593516 @default.
• W2070469043 cites W1983517537 @default.
• W2070469043 cites W1988158019 @default.
• W2070469043 cites W1997557974 @default.
• W2070469043 cites W2010027678 @default.
• W2070469043 cites W2022644634 @default.
• W2070469043 cites W2042209841 @default.
• W2070469043 cites W2042450805 @default.
• W2070469043 cites W2043173998 @default.
• W2070469043 cites W2063320302 @default.
• W2070469043 cites W2064527360 @default.
• W2070469043 cites W2065311537 @default.
• W2070469043 cites W2079784078 @default.
• W2070469043 cites W2083955937 @default.
• W2070469043 cites W2085039282 @default.
• W2070469043 cites W2087337342 @default.
• W2070469043 cites W2091615188 @default.
• W2070469043 cites W2098605310 @default.
• W2070469043 cites W2100505646 @default.
• W2070469043 cites W2103273955 @default.
• W2070469043 cites W2109539669 @default.
• W2070469043 cites W2118144386 @default.
• W2070469043 cites W2120744291 @default.
• W2070469043 cites W2137736246 @default.
• W2070469043 cites W2141260882 @default.
• W2070469043 cites W2153013281 @default.
• W2070469043 cites W2156063426 @default.
• W2070469043 cites W2157271336 @default.
• W2070469043 cites W2157952919 @default.
• W2070469043 cites W2161762223 @default.
• W2070469043 cites W2162725007 @default.
• W2070469043 cites W2167121410 @default.
• W2070469043 cites W2171581454 @default.
• W2070469043 cites W2198388460 @default.
• W2070469043 cites W2280563749 @default.
• W2070469043 cites W2406965583 @default.
• W2070469043 cites W2418862087 @default.
• W2070469043 doi "https://doi.org/10.1111/j.1523-1755.2005.00063.x" @default.
• W2070469043 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15610236" @default.
• W2070469043 hasPublicationYear "2005" @default.
• W2070469043 type Work @default.
• W2070469043 sameAs 2070469043 @default.
• W2070469043 citedByCount "41" @default.
• W2070469043 countsByYear W20704690432012 @default.
• W2070469043 countsByYear W20704690432013 @default.
• W2070469043 countsByYear W20704690432017 @default.
• W2070469043 countsByYear W20704690432019 @default.
• W2070469043 countsByYear W20704690432020 @default.
• W2070469043 countsByYear W20704690432021 @default.
• W2070469043 countsByYear W20704690432022 @default.
• W2070469043 crossrefType "journal-article" @default.
• W2070469043 hasAuthorship W2070469043A5026935880 @default.
• W2070469043 hasAuthorship W2070469043A5054014010 @default.
• W2070469043 hasAuthorship W2070469043A5071833047 @default.
• W2070469043 hasAuthorship W2070469043A5073356850 @default.
• W2070469043 hasAuthorship W2070469043A5090039049 @default.
• W2070469043 hasBestOaLocation W20704690431 @default.
• W2070469043 hasConcept C11960822 @default.
• W2070469043 hasConcept C12554922 @default.
• W2070469043 hasConcept C125705527 @default.
• W2070469043 hasConcept C142669718 @default.
• W2070469043 hasConcept C1491633281 @default.
• W2070469043 hasConcept C185592680 @default.
• W2070469043 hasConcept C203014093 @default.
• W2070469043 hasConcept C2777553839 @default.
• W2070469043 hasConcept C2993400109 @default.
• W2070469043 hasConcept C55493867 @default.
• W2070469043 hasConcept C86803240 @default.
• W2070469043 hasConcept C95444343 @default.
• W2070469043 hasConceptScore W2070469043C11960822 @default.
• W2070469043 hasConceptScore W2070469043C12554922 @default.
• W2070469043 hasConceptScore W2070469043C125705527 @default.
• W2070469043 hasConceptScore W2070469043C142669718 @default.
• W2070469043 hasConceptScore W2070469043C1491633281 @default.
• W2070469043 hasConceptScore W2070469043C185592680 @default.
• W2070469043 hasConceptScore W2070469043C203014093 @default.
• W2070469043 hasConceptScore W2070469043C2777553839 @default.
• W2070469043 hasConceptScore W2070469043C2993400109 @default.
• W2070469043 hasConceptScore W2070469043C55493867 @default.
• W2070469043 hasConceptScore W2070469043C86803240 @default.
• W2070469043 hasConceptScore W2070469043C95444343 @default.

• next