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- W2070475542 abstract "Abstract A myriad of nuclear noncoding RNAs (ncRNAs) have been discovered since the paradigm of RNAs as plain conveyors of protein translation was discarded. There is increasing evidence that at vital intersections of developmental pathways, ncRNAs target the chromatin modulating machinery to its site of action. However, the mechanistic details of processes involved are still largely unclear, and well‐characterized metazoan ncRNA species implicated in chromatin regulation during differentiation remain few. Nevertheless, four major categories are slowly emerging: cis ‐acting antisense ncRNAs that flag the neighboring genes for the propagation of chromatin marks; allele‐specific ncRNAs that perform similar tasks, but target larger loci that typically vary in size from hundreds of thousands of base pairs to a whole chromosome; structural ncRNAs proposed to act as scaffolds that couple chromatin shaping complexes of distinct functionalities; and cofactor ncRNAs with a capacity to inhibit or activate essential components of the intertwined chromatin and transcription apparatuses. WIREs Dev Biol 2012. doi: 10.1002/wdev.41 For further resources related to this article, please visit the WIREs website ." @default.
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- W2070475542 date "2012-02-22" @default.
- W2070475542 modified "2023-10-09" @default.
- W2070475542 title "The role of noncoding RNAs in chromatin regulation during differentiation" @default.
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- W2070475542 doi "https://doi.org/10.1002/wdev.41" @default.
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