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- W2070488568 abstract "The current models for colorectal cancer (CRC) are essentially linear in nature with a sequential progression from adenoma through to carcinoma. However, these views of CRC development do not explain the full body of published knowledge and tend to discount environmental influences. This paper proposes that CRC is a cellular response to prolonged exposure to cytotoxic agents (e.g., free ammonia) as key events within a sustained high-risk colonic luminal environment. This environment is low in substrate for the colonocytes (short chain fatty acids, SCFA) and consequently of higher pH with higher levels of free ammonia and decreased mucosal oxygen supply as a result of lower visceral blood flow. All of these lead to greater and prolonged exposure of the colonic epithelium to a cytotoxic agent with diminished aerobic energy availability. Normal colonocytes faced with this unfavourable environment can transform into CRC cells for survival through epigenetic reprogramming to express genes which increase mobility to allow migration and proliferation. Recent data with high protein diets confirm that genetic damage can be increased, consistent with greater CRC risk. However, this damage can be reversed by increasing SCFA supply by feeding fermentable fibre as resistant starch or arabinoxylan. High protein, low carbohydrate diets have been shown to alter the colonic environment with lower butyrate levels and apparently greater mucosal exposure to ammonia, consistent with our hypothesis. Evidence is drawn from in vivo and in vitro genomic and biochemical studies to frame experiments to test this proposition." @default.
- W2070488568 created "2016-06-24" @default.
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- W2070488568 date "2013-06-27" @default.
- W2070488568 modified "2023-10-05" @default.
- W2070488568 title "Colorectal Carcinogenesis: A Cellular Response to Sustained Risk Environment" @default.
- W2070488568 cites W1588926099 @default.
- W2070488568 cites W1713097109 @default.
- W2070488568 cites W1877854700 @default.
- W2070488568 cites W1893089770 @default.
- W2070488568 cites W1910222744 @default.
- W2070488568 cites W1953776819 @default.
- W2070488568 cites W1966960067 @default.
- W2070488568 cites W1975881786 @default.
- W2070488568 cites W1981989535 @default.
- W2070488568 cites W1983848577 @default.
- W2070488568 cites W1985358651 @default.
- W2070488568 cites W1990204500 @default.
- W2070488568 cites W1994687037 @default.
- W2070488568 cites W1994879784 @default.
- W2070488568 cites W1996730950 @default.
- W2070488568 cites W1998947396 @default.
- W2070488568 cites W1999316583 @default.
- W2070488568 cites W2001258296 @default.
- W2070488568 cites W2006731009 @default.
- W2070488568 cites W2007207450 @default.
- W2070488568 cites W2009807712 @default.
- W2070488568 cites W2010702833 @default.
- W2070488568 cites W2014444288 @default.
- W2070488568 cites W2022736837 @default.
- W2070488568 cites W2026707626 @default.
- W2070488568 cites W2030055342 @default.
- W2070488568 cites W2035628161 @default.
- W2070488568 cites W2041311742 @default.
- W2070488568 cites W2044348249 @default.
- W2070488568 cites W2047278992 @default.
- W2070488568 cites W2053718891 @default.
- W2070488568 cites W2057041675 @default.
- W2070488568 cites W2072533587 @default.
- W2070488568 cites W2075802734 @default.
- W2070488568 cites W2079202255 @default.
- W2070488568 cites W2082442098 @default.
- W2070488568 cites W2084166542 @default.
- W2070488568 cites W2089633816 @default.
- W2070488568 cites W2091116044 @default.
- W2070488568 cites W2096371251 @default.
- W2070488568 cites W2098297902 @default.
- W2070488568 cites W2098958992 @default.
- W2070488568 cites W2103547637 @default.
- W2070488568 cites W2105831375 @default.
- W2070488568 cites W2106611357 @default.
- W2070488568 cites W2107414352 @default.
- W2070488568 cites W2111839101 @default.
- W2070488568 cites W2111849727 @default.
- W2070488568 cites W2112351761 @default.
- W2070488568 cites W2112531759 @default.
- W2070488568 cites W2116846792 @default.
- W2070488568 cites W2118378798 @default.
- W2070488568 cites W2119515393 @default.
- W2070488568 cites W2120877678 @default.
- W2070488568 cites W2121243316 @default.
- W2070488568 cites W2121982452 @default.
- W2070488568 cites W2122411706 @default.
- W2070488568 cites W2124174471 @default.
- W2070488568 cites W2125585698 @default.
- W2070488568 cites W2128348076 @default.
- W2070488568 cites W2128416634 @default.
- W2070488568 cites W2129853415 @default.
- W2070488568 cites W2130585997 @default.
- W2070488568 cites W2131902769 @default.
- W2070488568 cites W2134222117 @default.
- W2070488568 cites W2135232490 @default.
- W2070488568 cites W2136131209 @default.
- W2070488568 cites W2141011376 @default.
- W2070488568 cites W2145819863 @default.
- W2070488568 cites W2147163130 @default.
- W2070488568 cites W2149515881 @default.
- W2070488568 cites W2153969740 @default.
- W2070488568 cites W2158579203 @default.
- W2070488568 cites W2158615962 @default.
- W2070488568 cites W2158971210 @default.
- W2070488568 cites W2168787308 @default.
- W2070488568 cites W2170127895 @default.
- W2070488568 cites W2236804207 @default.
- W2070488568 cites W2330504627 @default.
- W2070488568 cites W2335673557 @default.
- W2070488568 cites W2343388464 @default.
- W2070488568 cites W2472592177 @default.
- W2070488568 cites W4211090034 @default.
- W2070488568 cites W4240769795 @default.
- W2070488568 doi "https://doi.org/10.3390/ijms140713525" @default.
- W2070488568 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3742201" @default.