Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070492091> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2070492091 endingPage "892" @default.
- W2070492091 startingPage "886" @default.
- W2070492091 abstract "Paclitaxel-carrying lipospheres (MRX-552) were developed and evaluated as a new ultrasound contrast agent for chemotherapeutic drug delivery.Paclitaxel was suspended in soybean oil and added to an aqueous suspension of phospholipids in vials. The headspace of the vials was replaced with perfluorobutane gas; the vials were sealed, and they were agitated at 4200 rpm on a shaking device. The resulting lipospheres containing paclitaxel were studied for concentration, size, acute toxicity in mice, and acoustic activity and drug release with ultrasound. Lipospheres containing sudan black dye were produced to demonstrate the acoustically active liposphere (AAL)-ultrasound release concept.Acoustically active lipospheres containing paclitaxel had a mean particle count of approximately 1 x 10(9) particles per mL and a mean size of 2.9 microns. Acute toxicity studies in mice showed a 10-fold reduction in toxicity for paclitaxel in AALs compared with free paclitaxel. The AALs reflected ultrasound as a contrast agent. Increasing amounts of ultrasound energy selectively ruptured the AALs and released the paclitaxel.Acoustically active lipospheres represent a new class of acoustically active drug delivery vehicles. Future studies will assess efficacy of AALs for ultrasound-mediated drug delivery." @default.
- W2070492091 created "2016-06-24" @default.
- W2070492091 creator A5001749518 @default.
- W2070492091 creator A5005229735 @default.
- W2070492091 creator A5031113977 @default.
- W2070492091 creator A5069538913 @default.
- W2070492091 creator A5070747321 @default.
- W2070492091 date "1998-12-01" @default.
- W2070492091 modified "2023-10-13" @default.
- W2070492091 title "Acoustically Active Lipospheres Containing Paclitaxel" @default.
- W2070492091 cites W1976082197 @default.
- W2070492091 cites W1981953976 @default.
- W2070492091 cites W2000773538 @default.
- W2070492091 cites W2005574389 @default.
- W2070492091 cites W2054419802 @default.
- W2070492091 cites W2062963070 @default.
- W2070492091 cites W2327660288 @default.
- W2070492091 cites W4237050084 @default.
- W2070492091 doi "https://doi.org/10.1097/00004424-199812000-00007" @default.
- W2070492091 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9851823" @default.
- W2070492091 hasPublicationYear "1998" @default.
- W2070492091 type Work @default.
- W2070492091 sameAs 2070492091 @default.
- W2070492091 citedByCount "262" @default.
- W2070492091 countsByYear W20704920912012 @default.
- W2070492091 countsByYear W20704920912013 @default.
- W2070492091 countsByYear W20704920912014 @default.
- W2070492091 countsByYear W20704920912015 @default.
- W2070492091 countsByYear W20704920912016 @default.
- W2070492091 countsByYear W20704920912017 @default.
- W2070492091 countsByYear W20704920912018 @default.
- W2070492091 countsByYear W20704920912019 @default.
- W2070492091 countsByYear W20704920912020 @default.
- W2070492091 countsByYear W20704920912021 @default.
- W2070492091 countsByYear W20704920912022 @default.
- W2070492091 countsByYear W20704920912023 @default.
- W2070492091 crossrefType "journal-article" @default.
- W2070492091 hasAuthorship W2070492091A5001749518 @default.
- W2070492091 hasAuthorship W2070492091A5005229735 @default.
- W2070492091 hasAuthorship W2070492091A5031113977 @default.
- W2070492091 hasAuthorship W2070492091A5069538913 @default.
- W2070492091 hasAuthorship W2070492091A5070747321 @default.
- W2070492091 hasConcept C126838900 @default.
- W2070492091 hasConcept C141071460 @default.
- W2070492091 hasConcept C143753070 @default.
- W2070492091 hasConcept C147789679 @default.
- W2070492091 hasConcept C178790620 @default.
- W2070492091 hasConcept C185592680 @default.
- W2070492091 hasConcept C187530423 @default.
- W2070492091 hasConcept C2776694085 @default.
- W2070492091 hasConcept C2777292972 @default.
- W2070492091 hasConcept C2779820397 @default.
- W2070492091 hasConcept C43617362 @default.
- W2070492091 hasConcept C71924100 @default.
- W2070492091 hasConcept C72092618 @default.
- W2070492091 hasConcept C98274493 @default.
- W2070492091 hasConceptScore W2070492091C126838900 @default.
- W2070492091 hasConceptScore W2070492091C141071460 @default.
- W2070492091 hasConceptScore W2070492091C143753070 @default.
- W2070492091 hasConceptScore W2070492091C147789679 @default.
- W2070492091 hasConceptScore W2070492091C178790620 @default.
- W2070492091 hasConceptScore W2070492091C185592680 @default.
- W2070492091 hasConceptScore W2070492091C187530423 @default.
- W2070492091 hasConceptScore W2070492091C2776694085 @default.
- W2070492091 hasConceptScore W2070492091C2777292972 @default.
- W2070492091 hasConceptScore W2070492091C2779820397 @default.
- W2070492091 hasConceptScore W2070492091C43617362 @default.
- W2070492091 hasConceptScore W2070492091C71924100 @default.
- W2070492091 hasConceptScore W2070492091C72092618 @default.
- W2070492091 hasConceptScore W2070492091C98274493 @default.
- W2070492091 hasIssue "12" @default.
- W2070492091 hasLocation W20704920911 @default.
- W2070492091 hasLocation W20704920912 @default.
- W2070492091 hasOpenAccess W2070492091 @default.
- W2070492091 hasPrimaryLocation W20704920911 @default.
- W2070492091 hasRelatedWork W1996171153 @default.
- W2070492091 hasRelatedWork W2020785408 @default.
- W2070492091 hasRelatedWork W2029034519 @default.
- W2070492091 hasRelatedWork W2032368516 @default.
- W2070492091 hasRelatedWork W2035361107 @default.
- W2070492091 hasRelatedWork W2045698890 @default.
- W2070492091 hasRelatedWork W2050690740 @default.
- W2070492091 hasRelatedWork W2093359130 @default.
- W2070492091 hasRelatedWork W2135538021 @default.
- W2070492091 hasRelatedWork W2535752661 @default.
- W2070492091 hasVolume "33" @default.
- W2070492091 isParatext "false" @default.
- W2070492091 isRetracted "false" @default.
- W2070492091 magId "2070492091" @default.
- W2070492091 workType "article" @default.