FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070495870> ?p ?o ?g. }

• W2070495870 abstract "Sympathetic nerves regulate vascular tone by releasing neurotransmitters into the vasculature. We previously demonstrated that bradykinin facilitates sympathetic neurotransmission in rat mesenteric arteries. Although little is known about the intracellular mechanism modulating this neurotransmission, recent cell line experiments have shown that the KCNQ channel, which is inhibited by the depletion of membrane phosphatidylinositol-4,5-bisphosphate (PIP₂), participates in the control of neurotransmission by bradykinin. In the present study, we examined the mechanism regulating neurotransmitter release from rat perivascular sympathetic nerves. Excitatory junction potentials (EJPs) elicited by repetitive nerve stimulation (1 Hz, 11 pulses, 20 μs, 20-50 V), a measure of sympathetic purinergic neurotransmission, were recorded with a conventional microelectrode technique in rat mesenteric arteries. Bradykinin (10⁻⁷ mol l⁻¹) significantly enhanced the amplitude of EJPs (n=22, P<0.05). This enhancing effect was abolished by N-type calcium-channel inhibition with ω-conotoxin GVIA (2 × 10⁻⁹ mol ⁻¹l, n=8). The blockade of phospholipase C with U-73122 (10(-6) mol l⁻¹, n=17) also eliminated the facilitatory effect of bradykinin. In addition, the effects of bradykinin were diminished by the prevention of PIP₂ resynthesis with wortmannin (10⁻⁵ mol l⁻¹ n=7) or KCNQ channel inhibition with XE-991 (10⁻⁵ mol l⁻¹, n=7). On the other hand, depletion of intracellular calcium stores with cyclopiazonic acid (3 × 10⁻⁶ mol l⁻¹, n=6) or the inhibition of protein kinase C with bisindolylmaleimide-I (10⁻⁶ mol l⁻¹, n=9) did not alter the action of bradykinin. These data demonstrate that the hydrolysis of PIP₂ by phospholipase C, which is activated by G(q/11)-coupled receptors, and subsequent KCNQ channel inhibition enhance sympathetic purinergic neurotransmission presumably via the activation of N-type calcium channels in rat mesenteric arteries." @default.
• W2070495870 created "2016-06-24" @default.
• W2070495870 creator A5005015377 @default.
• W2070495870 creator A5005916554 @default.
• W2070495870 creator A5011680893 @default.
• W2070495870 creator A5067341497 @default.
• W2070495870 creator A5068572712 @default.
• W2070495870 creator A5081527635 @default.
• W2070495870 creator A5083985450 @default.
• W2070495870 date "2012-05-17" @default.
• W2070495870 modified "2023-10-13" @default.
• W2070495870 title "Facilitation of sympathetic neurotransmission by phosphatidylinositol-4,5-bisphosphate-dependent regulation of KCNQ channels in rat mesenteric arteries" @default.
• W2070495870 cites W1523338753 @default.
• W2070495870 cites W1601351641 @default.
• W2070495870 cites W1603834177 @default.
• W2070495870 cites W1664352025 @default.
• W2070495870 cites W1967203165 @default.
• W2070495870 cites W1975279491 @default.
• W2070495870 cites W1983428945 @default.
• W2070495870 cites W1988174555 @default.
• W2070495870 cites W1997158966 @default.
• W2070495870 cites W1997537641 @default.
• W2070495870 cites W2000141771 @default.
• W2070495870 cites W2006591940 @default.
• W2070495870 cites W2009313213 @default.
• W2070495870 cites W2009560301 @default.
• W2070495870 cites W2016183904 @default.
• W2070495870 cites W2019177723 @default.
• W2070495870 cites W2021205474 @default.
• W2070495870 cites W2026244102 @default.
• W2070495870 cites W2034017138 @default.
• W2070495870 cites W2037924100 @default.
• W2070495870 cites W2038036955 @default.
• W2070495870 cites W2041229815 @default.
• W2070495870 cites W2042824689 @default.
• W2070495870 cites W2044038692 @default.
• W2070495870 cites W2046153118 @default.
• W2070495870 cites W2047069083 @default.
• W2070495870 cites W2048444015 @default.
• W2070495870 cites W2048924952 @default.
• W2070495870 cites W2050453497 @default.
• W2070495870 cites W2051979908 @default.
• W2070495870 cites W2058346833 @default.
• W2070495870 cites W2059398421 @default.
• W2070495870 cites W2062353585 @default.
• W2070495870 cites W2066551451 @default.
• W2070495870 cites W2071197760 @default.
• W2070495870 cites W2087569926 @default.
• W2070495870 cites W2089060665 @default.
• W2070495870 cites W2096225389 @default.
• W2070495870 cites W2106994133 @default.
• W2070495870 cites W2112272723 @default.
• W2070495870 cites W2115565372 @default.
• W2070495870 cites W2116437973 @default.
• W2070495870 cites W2122008829 @default.
• W2070495870 cites W2123917020 @default.
• W2070495870 cites W2125936170 @default.
• W2070495870 cites W2128953287 @default.
• W2070495870 cites W2137046511 @default.
• W2070495870 cites W2137823672 @default.
• W2070495870 cites W2143035110 @default.
• W2070495870 cites W2143242953 @default.
• W2070495870 cites W2148874656 @default.
• W2070495870 cites W2159911721 @default.
• W2070495870 cites W2164458919 @default.
• W2070495870 cites W2167366932 @default.
• W2070495870 doi "https://doi.org/10.1038/hr.2012.61" @default.
• W2070495870 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22592664" @default.
• W2070495870 hasPublicationYear "2012" @default.
• W2070495870 type Work @default.
• W2070495870 sameAs 2070495870 @default.
• W2070495870 citedByCount "3" @default.
• W2070495870 countsByYear W20704958702013 @default.
• W2070495870 countsByYear W20704958702014 @default.
• W2070495870 countsByYear W20704958702016 @default.
• W2070495870 crossrefType "journal-article" @default.
• W2070495870 hasAuthorship W2070495870A5005015377 @default.
• W2070495870 hasAuthorship W2070495870A5005916554 @default.
• W2070495870 hasAuthorship W2070495870A5011680893 @default.
• W2070495870 hasAuthorship W2070495870A5067341497 @default.
• W2070495870 hasAuthorship W2070495870A5068572712 @default.
• W2070495870 hasAuthorship W2070495870A5081527635 @default.
• W2070495870 hasAuthorship W2070495870A5083985450 @default.
• W2070495870 hasBestOaLocation W20704958701 @default.
• W2070495870 hasConcept C126322002 @default.
• W2070495870 hasConcept C134018914 @default.
• W2070495870 hasConcept C170493617 @default.
• W2070495870 hasConcept C185592680 @default.
• W2070495870 hasConcept C200170125 @default.
• W2070495870 hasConcept C2776820930 @default.
• W2070495870 hasConcept C2778308172 @default.
• W2070495870 hasConcept C2778597717 @default.
• W2070495870 hasConcept C2779591629 @default.
• W2070495870 hasConcept C2780610907 @default.
• W2070495870 hasConcept C2780771799 @default.
• W2070495870 hasConcept C62478195 @default.
• W2070495870 hasConcept C71924100 @default.
• W2070495870 hasConcept C86803240 @default.
• W2070495870 hasConcept C95444343 @default.
• W2070495870 hasConceptScore W2070495870C126322002 @default.

• next