Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070501211> ?p ?o ?g. }
- W2070501211 endingPage "78" @default.
- W2070501211 startingPage "65" @default.
- W2070501211 abstract "Asymmetric division of progenitor/stem cells generates both self-renewing and differentiating progeny and is fundamental to development and regeneration. How this process is regulated in the vertebrate brain remains incompletely understood. Here, we use time-lapse imaging to track radial glia progenitor behavior in the developing zebrafish brain. We find that asymmetric division invariably generates a basal self-renewing daughter and an apical differentiating sibling. Gene expression and genetic mosaic analysis further show that the apical daughter is the source of Notch ligand that is essential to maintain higher Notch activity in the basal daughter. Notably, establishment of this intralineage and directional Notch signaling requires the intrinsic polarity regulator Partitioning defective protein-3 (Par-3), which segregates the fate determinant Mind bomb unequally to the apical daughter, thereby restricting the self-renewal potential to the basal daughter. These findings reveal with single-cell resolution how self-renewal and differentiation become precisely segregated within asymmetrically dividing neural progenitor/stem lineages." @default.
- W2070501211 created "2016-06-24" @default.
- W2070501211 creator A5024881689 @default.
- W2070501211 creator A5059737137 @default.
- W2070501211 creator A5065315410 @default.
- W2070501211 creator A5084846015 @default.
- W2070501211 creator A5085722199 @default.
- W2070501211 date "2012-04-01" @default.
- W2070501211 modified "2023-10-18" @default.
- W2070501211 title "Intralineage Directional Notch Signaling Regulates Self-Renewal and Differentiation of Asymmetrically Dividing Radial Glia" @default.
- W2070501211 cites W1503727145 @default.
- W2070501211 cites W1505954215 @default.
- W2070501211 cites W1643680178 @default.
- W2070501211 cites W1964026482 @default.
- W2070501211 cites W1966398860 @default.
- W2070501211 cites W1969252152 @default.
- W2070501211 cites W1969995228 @default.
- W2070501211 cites W1974059924 @default.
- W2070501211 cites W1975702084 @default.
- W2070501211 cites W1976572966 @default.
- W2070501211 cites W1979755285 @default.
- W2070501211 cites W1979895839 @default.
- W2070501211 cites W1981563641 @default.
- W2070501211 cites W1982289883 @default.
- W2070501211 cites W1982612184 @default.
- W2070501211 cites W1982986130 @default.
- W2070501211 cites W1984243695 @default.
- W2070501211 cites W1985657116 @default.
- W2070501211 cites W1986317670 @default.
- W2070501211 cites W1987582818 @default.
- W2070501211 cites W1988976106 @default.
- W2070501211 cites W1993115402 @default.
- W2070501211 cites W1994467664 @default.
- W2070501211 cites W1997715976 @default.
- W2070501211 cites W2009495925 @default.
- W2070501211 cites W2010867010 @default.
- W2070501211 cites W2013666169 @default.
- W2070501211 cites W2014415534 @default.
- W2070501211 cites W2021515035 @default.
- W2070501211 cites W2024570416 @default.
- W2070501211 cites W2026288887 @default.
- W2070501211 cites W2028480293 @default.
- W2070501211 cites W2032850366 @default.
- W2070501211 cites W2033255797 @default.
- W2070501211 cites W2038970717 @default.
- W2070501211 cites W2039075455 @default.
- W2070501211 cites W2041482422 @default.
- W2070501211 cites W2045044865 @default.
- W2070501211 cites W2045315596 @default.
- W2070501211 cites W2046081464 @default.
- W2070501211 cites W2053216321 @default.
- W2070501211 cites W2055064474 @default.
- W2070501211 cites W2055727049 @default.
- W2070501211 cites W2060645534 @default.
- W2070501211 cites W2068432076 @default.
- W2070501211 cites W2075047490 @default.
- W2070501211 cites W2075947758 @default.
- W2070501211 cites W2078451104 @default.
- W2070501211 cites W2079978401 @default.
- W2070501211 cites W2086265537 @default.
- W2070501211 cites W2088814620 @default.
- W2070501211 cites W2095387881 @default.
- W2070501211 cites W2099791270 @default.
- W2070501211 cites W2107209236 @default.
- W2070501211 cites W2108239878 @default.
- W2070501211 cites W2115060735 @default.
- W2070501211 cites W2119309845 @default.
- W2070501211 cites W2125349610 @default.
- W2070501211 cites W2127220436 @default.
- W2070501211 cites W2128968777 @default.
- W2070501211 cites W2141638818 @default.
- W2070501211 cites W2149871164 @default.
- W2070501211 cites W2151777177 @default.
- W2070501211 cites W2154861644 @default.
- W2070501211 cites W2157681993 @default.
- W2070501211 cites W2159418321 @default.
- W2070501211 cites W2160645053 @default.
- W2070501211 cites W2165981305 @default.
- W2070501211 cites W2167133646 @default.
- W2070501211 cites W2168945089 @default.
- W2070501211 cites W2170574208 @default.
- W2070501211 cites W2171445737 @default.
- W2070501211 cites W2172266256 @default.
- W2070501211 cites W4241595688 @default.
- W2070501211 cites W4379392213 @default.
- W2070501211 doi "https://doi.org/10.1016/j.neuron.2012.01.031" @default.
- W2070501211 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3466114" @default.
- W2070501211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22500631" @default.
- W2070501211 hasPublicationYear "2012" @default.
- W2070501211 type Work @default.
- W2070501211 sameAs 2070501211 @default.
- W2070501211 citedByCount "118" @default.
- W2070501211 countsByYear W20705012112012 @default.
- W2070501211 countsByYear W20705012112013 @default.
- W2070501211 countsByYear W20705012112014 @default.
- W2070501211 countsByYear W20705012112015 @default.
- W2070501211 countsByYear W20705012112016 @default.
- W2070501211 countsByYear W20705012112017 @default.