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• W2070505667 startingPage "271" @default.
• W2070505667 abstract "Owing to the continual turnover of afferent input, the olfactory system offers a unique opportunity to study development and reorganization of neuronal networks in adults. To explore substrates that may underlie these processes in the adult olfactory system, we examined the expression and distribution of extracellular matrix and cell adhesion molecules (CAM) thought to be involved in axon guidance/extension. N-CAM, laminin, and tenascin were all detected by immunocytochemistry in the nerve and glomerular layers of the adult rat olfactory bulb, although the intensity and laminar distribution were varied. Antisera for N-CAM(total), N-CAM180, and tenascin bound to fascicles within the olfactory nerve layer and the glomerular neuropil. However, binding was nonuniform in that only subsets of axon fascicles and restricted glomeruli showed evidence of immunoreactivity. Antilaminin and a polyclonal antitenascin similarly exhibited heterogeneous intralaminar immunoreactivity. Tenascin colocalized with glial processes at the borders of glomeruli and subcompartments of the glomerular neuropil. Laminin immunoreactivity was evident in subsets of olfactory nerve fascicles and, to a lesser extent, the glomeruli. The data are consistent with the notion that ongoing axon extension and glomerular targeting in the olfactory system is subserved in part by a heterogeneous expression of the same extracellular matrix and CAMs present at higher levels during perinatal development." @default.
• W2070505667 created "2016-06-24" @default.
• W2070505667 creator A5003469942 @default.
• W2070505667 creator A5082981481 @default.
• W2070505667 date "1998-02-15" @default.
• W2070505667 modified "2023-09-24" @default.
• W2070505667 title "Differential expression of extracellular matrix and cell adhesion molecules in the olfactory nerve and glomerular layers of adult rats" @default.
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• W2070505667 doi "https://doi.org/10.1002/(sici)1097-4695(19980215)34:3<271::aid-neu6>3.0.co;2-#" @default.
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