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- W2070506750 abstract "We have studied the relationship between major histocompatibility complex (MHC)-restricted antigen recognition and alloreactivity by examining T cell receptor (TCR) α and β gene expression in cytochrome c-specific, Ekα:Ekβ (Ek)-restricted helper T cell clones derived from B10.A mice. The clones could be segregated on the basis of four distinct alloreactivity patterns. Clones cross-reactive for three different allogeneic la molecules (Asα:Asβ [As], Abα:Abβ [Ab], Ekα:Ebβ [Eb]) expressed the same Vα and Vβ gene segments, generating the distinct alloreactive specificities via unique Vα-Jα and Vβ-Dβ-Jβ joining events. Ekα:Esβ (Es)-alloreactive B10. A clones expressed the same Vα, Jα, and Vβ segments as an Es-restricted, Ek-alloreactive, cytochrome c-specific, H-2-congenic B10.S(9R) clone. This homology between TCRs mediating allorecognition of la molecules and recognition of the same la molecules as restriction elements associated with nominal antigen suggests that MHC-restricted recognition and allorecognition represent differences in the affinity of the TCR-MHC molecule interaction." @default.
- W2070506750 created "2016-06-24" @default.
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- W2070506750 date "2000-08-01" @default.
- W2070506750 modified "2023-09-25" @default.
- W2070506750 title "Human T-cell receptor variable gene analysis against porcine peripheral lymphocytes" @default.
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- W2070506750 doi "https://doi.org/10.1016/s0041-1345(00)01055-1" @default.
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