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• W2070507515 endingPage "1097" @default.
• W2070507515 startingPage "1091" @default.
• W2070507515 abstract "Telomerase RNA is an integral part of telomerase, the ribonucleoprotein enzyme that catalyzes the synthesis of telomeric DNA. The RNA moiety contains a templating domain that directs the synthesis of a species-specific telomeric repeat and may also be important for enzyme structure and/or catalysis. Phylogenetic comparisons of telomerase RNA sequences from various Tetrahymena spp. and hypotrich ciliates have revealed two conserved secondary structure models that share many features. We have cloned and sequenced the telomerase RNA genes from an additional six Tetrahymena spp. (T. vorax, T. borealis, T. australis, T. silvana, T. capricornis and T. paravorax). Inclusion of these sequences, most notably that from T. paravorax, in a phylogenetic comparative analysis allowed us to more narrowly define structural elements that may be necessary for a minimal telomerase RNA. A primary sequence element, positioned 5' of the template and conserved between all previously known ciliate telomerase RNAs, has been reduced from 5'-(C)UGUCA-3' to the 4 nt sequence 5'-GUCA-3'. Conserved secondary structural features and the impact they have on the general organization of ciliate telomerase RNAs is discussed." @default.
• W2070507515 created "2016-06-24" @default.
• W2070507515 creator A5062576570 @default.
• W2070507515 creator A5080069764 @default.
• W2070507515 date "1995-01-01" @default.
• W2070507515 modified "2023-09-23" @default.
• W2070507515 title "Ciliate telomerase RNA structural features" @default.
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• W2070507515 doi "https://doi.org/10.1093/nar/23.7.1091" @default.
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