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• W2070513612 abstract "Parkinson disease (PD) is a chronic neurodegenerative disease characterized by a slow and progressive degeneration of dopaminergic neurons in substantia nigra. The pathophysiological mechanisms underlying PD remain unclear. Pin1, a major peptidyl-prolyl isomerase, has recently been associated with certain diseases. Notably, Ryo et al. (Ryo, A., Togo, T., Nakai, T., Hirai, A., Nishi, M., Yamaguchi, A., Suzuki, K., Hirayasu, Y., Kobayashi, H., Perrem, K., Liou, Y. C., and Aoki, I. (2006) J. Biol. Chem. 281, 4117-4125) implicated Pin1 in PD pathology. Therefore, we sought to systematically characterize the role of Pin1 in PD using cell culture and animal models. To our surprise we observed a dramatic up-regulation of Pin1 mRNA and protein levels in dopaminergic MN9D neuronal cells treated with the parkinsonian toxicant 1-methyl-4-phenylpyridinium (MPP(+)) as well as in the substantia nigra of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mouse model. Notably, a marked expression of Pin1 was also observed in the substantia nigra of human PD brains along with a high co-localization of Pin1 within dopaminergic neurons. In functional studies, siRNA-mediated knockdown of Pin1 almost completely prevented MPP(+)-induced caspase-3 activation and DNA fragmentation, indicating that Pin1 plays a proapoptotic role. Interestingly, multiple pharmacological Pin1 inhibitors, including juglone, attenuated MPP(+)-induced Pin1 up-regulation, α-synuclein aggregation, caspase-3 activation, and cell death. Furthermore, juglone treatment in the MPTP mouse model of PD suppressed Pin1 levels and improved locomotor deficits, dopamine depletion, and nigral dopaminergic neuronal loss. Collectively, our findings demonstrate for the first time that Pin1 is up-regulated in PD and has a pathophysiological role in the nigrostriatal dopaminergic system and suggest that modulation of Pin1 levels may be a useful translational therapeutic strategy in PD." @default.
• W2070513612 created "2016-06-24" @default.
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• W2070513612 date "2013-07-01" @default.
• W2070513612 modified "2023-10-16" @default.
• W2070513612 title "The Peptidyl-prolyl Isomerase Pin1 Up-regulation and Proapoptotic Function in Dopaminergic Neurons" @default.
• W2070513612 cites W1541944730 @default.
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• W2070513612 cites W1583938558 @default.
• W2070513612 cites W1602112568 @default.
• W2070513612 cites W1965991145 @default.
• W2070513612 cites W1966165558 @default.
• W2070513612 cites W1968273731 @default.
• W2070513612 cites W1973353614 @default.
• W2070513612 cites W1974074671 @default.
• W2070513612 cites W1974361709 @default.
• W2070513612 cites W1981172305 @default.
• W2070513612 cites W1981564494 @default.
• W2070513612 cites W1982137838 @default.
• W2070513612 cites W1985131241 @default.
• W2070513612 cites W1989013188 @default.
• W2070513612 cites W1990072408 @default.
• W2070513612 cites W2006413040 @default.
• W2070513612 cites W2007217024 @default.
• W2070513612 cites W2011383001 @default.
• W2070513612 cites W2019019227 @default.
• W2070513612 cites W2030025610 @default.
• W2070513612 cites W2032870207 @default.
• W2070513612 cites W2033655573 @default.
• W2070513612 cites W2034230941 @default.
• W2070513612 cites W2034459537 @default.
• W2070513612 cites W2044098205 @default.
• W2070513612 cites W2045734312 @default.
• W2070513612 cites W2047206971 @default.
• W2070513612 cites W2050604139 @default.
• W2070513612 cites W2052341819 @default.
• W2070513612 cites W2054421268 @default.
• W2070513612 cites W2060000964 @default.
• W2070513612 cites W2062371417 @default.
• W2070513612 cites W2063107060 @default.
• W2070513612 cites W2065057380 @default.
• W2070513612 cites W2068462701 @default.
• W2070513612 cites W2071760372 @default.
• W2070513612 cites W2079481706 @default.
• W2070513612 cites W2084965902 @default.
• W2070513612 cites W2087953279 @default.
• W2070513612 cites W2091798758 @default.
• W2070513612 cites W2093258807 @default.
• W2070513612 cites W2096789813 @default.
• W2070513612 cites W2098132374 @default.
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• W2070513612 cites W2114118618 @default.
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• W2070513612 doi "https://doi.org/10.1074/jbc.m112.444224" @default.
• W2070513612 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3724650" @default.
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• W2070513612 hasPublicationYear "2013" @default.
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